| Size | Price | Stock | Qty |
|---|---|---|---|
| 500mg |
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| Other Sizes |
| Targets |
Amino acid
DL-Arginine does not have a specific therapeutic target but serves as a model compound for studying amino acid chemistry. L-Arginine is the biologically active form and is a precursor for the synthesis of nitric oxide (NO), creatine, and polyamines. The D-enantiomer is not incorporated into proteins and is primarily used in research. As a racemic mixture, DL-Arginine contains both the active L-form and the inactive D-form. It is used in physicochemical analysis of amino acid complexation dynamics and crystal structure formations. |
|---|---|
| ln Vitro |
Arginine is an alpha-amino acid that is glycine in which the alpha-is substituted by a 3-guanidinopropyl group. It has a role as a fundamental metabolite. It is an alpha-amino acid, a member of guanidines and a polar amino acid. It contains a 3-carbamimidamidopropyl group. It is a conjugate base of an argininium(1+). It is a conjugate acid of an argininate.
DL-Arginine has been reported in Daphnia pulex, Drosophila melanogaster.
In vitro, DL-Arginine is used as a model compound in physicochemical and structural studies. It is used to study amino acid complexation dynamics, hydrogen bonding, and ionic interactions. It is also used as a substrate in biochemical research. Its primary activity is as a chemical reagent, not as a pharmacologically active compound with a specific potency. |
| ln Vivo |
In vivo, L-Arginine is a conditionally essential amino acid that is critical for growth, tissue repair, and immune function. It is a precursor for the synthesis of nitric oxide (NO), a key signaling molecule involved in vasodilation and immune function. DL-Arginine is not used clinically; L-arginine is the biologically active form.
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| Enzyme Assay |
In vitro non-cell enzyme assays are not applicable for DL-Arginine, as it is a chemical reagent. Its properties are typically assessed using analytical techniques such as HPLC or amino acid analysis to determine its purity and concentration.
|
| Cell Assay |
In vitro cell-based assays for DL-Arginine are used to study its effects on cell growth and metabolism. Cells are cultured in media containing varying concentrations of arginine, and parameters such as cell proliferation, nitric oxide production, and gene expression are assessed. These studies help to elucidate the role of arginine in cellular function and metabolism.
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| Animal Protocol |
In vivo animal studies for DL-Arginine are primarily nutritional studies conducted to determine the arginine requirements of various animal species. Animals are fed diets with varying levels of arginine, and growth performance, feed efficiency, and nitrogen balance are measured. These studies are essential for formulating balanced diets for livestock and poultry.
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| ADME/Pharmacokinetics |
DL-Arginine has a molecular weight of 174.20 g/mol and a molecular formula of C₆H₁₄N₄O₂. It is a white crystalline powder that is soluble in water. It has a melting point of 228-233°C (dec.). It should be stored in a cool, dry place, protected from moisture.
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| Toxicity/Toxicokinetics |
DL-Arginine is generally recognized as safe (GRAS) when used as a nutritional supplement. It is non-toxic at normal dietary levels. However, excessive intake may cause gastrointestinal distress. The compound is not intended for therapeutic use as a drug. Standard laboratory safety precautions should be followed when handling the compound.
|
| References |
[1]. https://pubchem.ncbi.nlm.nih.gov/compound/232
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| Additional Infomation |
Arginine is an α-amino acid, formed by substituting a 3-guanidinopropyl group at the α-position of glycine. It is an important metabolite. It is an α-amino acid belonging to the guanidine family and is also a polar amino acid. It contains a 3-carbamoimidopropyl group. It is the conjugate base of arginine (1+) and the conjugate acid of arginine. DL-arginine has been reported in Daphnia pulex, Drosophila melanogaster, and several other organisms with relevant data. See also: Arginine hydrochloride (note moved to).
DL-Arginine is the racemic form of the amino acid arginine, used in physicochemical and structural studies. It is used in the synthesis of creatine and polyamines. Not a drug; used as a research reagent and chemical standard. |
| Molecular Formula |
C6H14N4O2
|
|---|---|
| Molecular Weight |
174.20096
|
| Exact Mass |
174.111
|
| Elemental Analysis |
C, 41.37; H, 8.10; N, 32.16; O, 18.37
|
| CAS # |
7200-25-1
|
| Related CAS # |
L-Arginine;74-79-3;L-Arginine hydrochloride;1119-34-2;L-Arginine (L-glutamate);4320-30-3
|
| PubChem CID |
232
|
| Appearance |
White to off-white solid powder
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| Density |
1.5±0.1 g/cm3
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| Boiling Point |
367.6±52.0 °C at 760 mmHg
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| Melting Point |
228-232ºC
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| Flash Point |
176.1±30.7 °C
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| Vapour Pressure |
0.0±1.8 mmHg at 25°C
|
| Index of Refraction |
1.601
|
| LogP |
-1.79
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| Hydrogen Bond Donor Count |
4
|
| Hydrogen Bond Acceptor Count |
4
|
| Rotatable Bond Count |
5
|
| Heavy Atom Count |
12
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| Complexity |
176
|
| Defined Atom Stereocenter Count |
0
|
| InChi Key |
ODKSFYDXXFIFQN-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)
|
| Chemical Name |
2-amino-5-(diaminomethylideneamino)pentanoic acid
|
| Synonyms |
DL-Arginine; 7200-25-1; Arginine, DL-; 2-amino-5-guanidinopentanoic acid; L(+)-Arginine; MFCD00063117; 7004-12-8; FL26NTK3EP;
|
| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
H2O : ~125 mg/mL (~717.57 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 50 mg/mL (287.03 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 5.7405 mL | 28.7026 mL | 57.4053 mL | |
| 5 mM | 1.1481 mL | 5.7405 mL | 11.4811 mL | |
| 10 mM | 0.5741 mL | 2.8703 mL | 5.7405 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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