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    Diphenidol HCl (Difenidol)
    Diphenidol HCl (Difenidol)

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1167
    CAS #: 3254-89-5Purity ≥98%

    Description: Diphenidol HCl (Vontrol; Difenidol), the hydrochloride salt of diphenidol which is an antiemetic, is a potent antagonist of muscarinic M2 and M3 receptors used as an antiemetic and as an antivertigo agent. It inhibits muscarinic M2 and M3 receptors with pKb values of 6.72 and 7.02, respectively. Diphenidol has been approved for the treatment of vomiting and vertigo. Although the mechanism of action of Diphenidol on the vestibular system has not yet been elucidated, it exerts an anticholinergic effect due to interactions with mACh receptors, particularly M1, M2, M3 and M4. 

    References: Neurosci Lett. 2015 Mar 4;589:62-6.

    Related CAS#: 972-02-1 (free base); 3254-89-5 (HCl)

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    Molecular Weight (MW)345.91
    FormulaC21H28ClNO
    CAS No.3254-89-5
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 69 mg/mL (199.5 mM)
    Water: 13 mg/mL (37.6 mM) 
    Ethanol: 36 mg/mL (104.1 mM)
    Other info

    Chemical Name: 1,1-Diphenyl-4-piperidin-1-ylbutan-1-ol hydrochloride

    InChi Key: AVZIYZHXZAYGJS-UHFFFAOYSA-N

    InChi Code: InChI=1S/C21H27NO.ClH/c23-21(19-11-4-1-5-12-19,20-13-6-2-7-14-20)15-10-18-22-16-8-3-9-17-22;/h1-2,4-7,11-14,23H,3,8-10,15-18H2;1H

    SMILES Code: OC(C1=CC=CC=C1)(C2=CC=CC=C2)CCCN3CCCCC3.[H]Cl

    SynonymsDifenidol hydrochloride


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