Size | Price | Stock | Qty |
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500mg |
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1g |
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2g |
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5g |
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10g |
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25g |
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50g |
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Other Sizes |
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Purity: ≥98%
Diphenidol HCl (Vontrol; Difenidol), the hydrochloride salt of diphenidol which is an antiemetic, is a potent antagonist of muscarinic M2 and M3 receptors used as an antiemetic and as an antivertigo agent. It inhibits muscarinic M2 and M3 receptors with pKb values of 6.72 and 7.02, respectively. Diphenidol has been approved for the treatment of vomiting and vertigo. Although the mechanism of action of Diphenidol on the vestibular system has not yet been elucidated, it exerts an anticholinergic effect due to interactions with mACh receptors, particularly M1, M2, M3 and M4.
References |
Neurosci Lett.2015 Mar 4;589:62-6.
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Molecular Formula |
C21H28CLNO
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Molecular Weight |
345.91
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CAS # |
3254-89-5
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SMILES |
OC(C1=CC=CC=C1)(C2=CC=CC=C2)CCCN3CCCCC3.[H]Cl
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InChi Key |
AVZIYZHXZAYGJS-UHFFFAOYSA-N
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InChi Code |
InChI=1S/C21H27NO.ClH/c23-21(19-11-4-1-5-12-19,20-13-6-2-7-14-20)15-10-18-22-16-8-3-9-17-22;/h1-2,4-7,11-14,23H,3,8-10,15-18H2;1H
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Chemical Name |
1,1-Diphenyl-4-piperidin-1-ylbutan-1-ol hydrochloride
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Synonyms |
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
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Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
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Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 2.8909 mL | 14.4546 mL | 28.9093 mL | |
5 mM | 0.5782 mL | 2.8909 mL | 5.7819 mL | |
10 mM | 0.2891 mL | 1.4455 mL | 2.8909 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.