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Description: Diphenidol HCl (Vontrol; Difenidol), the hydrochloride salt of diphenidol which is an antiemetic, is a potent antagonist of muscarinic M2 and M3 receptors used as an antiemetic and as an antivertigo agent. It inhibits muscarinic M2 and M3 receptors with pKb values of 6.72 and 7.02, respectively. Diphenidol has been approved for the treatment of vomiting and vertigo. Although the mechanism of action of Diphenidol on the vestibular system has not yet been elucidated, it exerts an anticholinergic effect due to interactions with mACh receptors, particularly M1, M2, M3 and M4.
References: Neurosci Lett. 2015 Mar 4;589:62-6.
Related CAS#: 972-02-1 (free base); 3254-89-5 (HCl)
Chemical Name: 1,1-Diphenyl-4-piperidin-1-ylbutan-1-ol hydrochloride
InChi Key: AVZIYZHXZAYGJS-UHFFFAOYSA-N
InChi Code: InChI=1S/C21H27NO.ClH/c23-21(19-11-4-1-5-12-19,20-13-6-2-7-14-20)15-10-18-22-16-8-3-9-17-22;/h1-2,4-7,11-14,23H,3,8-10,15-18H2;1H
SMILES Code: OC(C1=CC=CC=C1)(C2=CC=CC=C2)CCCN3CCCCC3.[H]Cl
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2
Purity ≥98%
COA
MSDS