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    Diphemanil Methylsulfate
    Diphemanil Methylsulfate

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1195
    CAS #: 62-97-5Purity ≥98%

    Description: Diphemanil methylsulfate (NSC 41725; NSC-41725; Prantal; Talpran; Diphemanil mesylate) is a quaternary ammonium anticholinergic agent used for a variety of conditions such as pylorospasm, peptic ulcer, gastric hyperacidity, hypermotility in gastritis, and hyperhidrosis. It acts by binding to muscarinic acetycholine receptors (mAchR), thus decreasing secretory excretion of stomach acids as well as saliva and sweat. 

    References: Eur J Clin Pharmacol. 1992;42(6):689-91.

    Related CAS #: 62-97-5 (methylsulfate); 15394-62-4 (cation); 

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    Molecular Weight (MW)389.51 
    FormulaC20H24N.CH3O4S 
    CAS No.62-97-5; 15394-62-4 (cation)
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 25 mg/mL (64.2 mM) 
    Water: 28 mg/mL (71.9 mM) 
    Ethanol: <1 mg/mL
    SMILES[O-]S(=O)(OC)=O.C[N+]1(C)CC/C(CC1)=C(C2=CC=CC=C2)\C3=CC=CC=C3
    Synonyms

    NSC41725; Diphemanil Methylsulfate; NSC 41725; NSC-41725; Prantal; Talpran;

    Chemical Name: 4-(diphenylmethylene)-1,1-dimethylpiperidin-1-ium methyl sulfate


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    In Vitro

    In vitro activity: Diphemanil Methylsulfate exerts its action by primarily binding the muscarinic M3 receptor. In addition to its well known antimuscarinic effects, Diphemanil Methylsulfate also possesses direct smooth muscle spasmolytic activity. 

    In VivoThe pharmacokinetic experiments show that absorption of diphemanil methylsulphate is slow (tmax = 2 to 4 h), the mean half-life is 8.35 h, and the amount of the drug recovered in urine within 48 h ranges from 0.6 to 7.4% of the administered dose. Poorly absorbed from the gastrointestinal tract with an absolute bioavailability of 15 to 25%.  
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    References

    Eur J Clin Pharmacol. 1992;42(6):689-91. 


    These protocols are for reference only. InvivoChem does not independently validate these methods.

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