Size | Price | Stock | Qty |
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5mg |
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10mg |
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50mg |
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100mg |
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Other Sizes |
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Dinoprost (Prostaglandin F2alpha) is a potent, naturally occurring and orally bioactive prostaglandin that acts as a prostaglandin F (PGF) receptor (FP receptor) agonist with oxytocic, luteolytic, and abortifacient activities. It is a naturally occurring luteolytic hormone produced locally in the endometrial luminal epithelium and corpus luteum (CL), and plays a key role in the onset and progression of labour, also used as a prostaglandin in medicine to induce labor.
ln Vitro |
Goat luteal cells undergo necrosis, autophagy, and endoplasmic reticulum prolapse when exposed to dinoprost (prostaglandin F2α; 1 μM) for a full day [1]. Dinoprost (1 μM) raised GRP78 and UPR sensor substantially throughout a 24-hour period.
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Cell Assay |
Apoptosis analysis [1]
Cell Types: Goat luteal cells Tested Concentrations: 1 μM Incubation Duration: 24 hrs (hours) Experimental Results: Significant apoptosis rate increased (15.62±3.12%). Autophagy detection [1] Cell Types: goat luteal cells Tested Concentrations: 1 μM Incubation Duration: 24 hrs (hours) Experimental Results: There is extensive overlap between LC3 and LAMP1 in luteal cells, and autophagic lysosomes are formed in goat luteal cells. Western Blot Analysis[1] Cell Types: Goat luteal cells Tested Concentrations: 1 μM Incubation Duration: 24 hrs (hours) Experimental Results: Expression of GRP78 and UPR sensors, including cleaved ATF6, phospho-EIF2S1, EIF2S1, ATF4, phospho-IRE1, autologous Phagocytosis-related intracellular protein LC3-II and pro-apoptotic factor cleaved Caspase3 were Dramatically increased. |
References |
[1]. Hagen Thieme, et al. Endothelin antagonism: effects of FP receptor agonists prostaglandin F2alpha and fluprostenol on trabecular meshwork contractility. Invest Ophthalmol Vis Sci. 2006 Mar;47(3):938-45.
[2]. Xin Wen, et al. Prostaglandin F2α Induces Goat Corpus Luteum Regression via Endoplasmic Reticulum Stress and Autophagy. Front Physiol. 2020 Sep 11;11:868. |
Molecular Formula |
C20H34O5
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Molecular Weight |
354.4810
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CAS # |
551-11-1
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Related CAS # |
Dinoprost tromethamine salt;38562-01-5;(5R)-Dinoprost;4510-16-1;Dinoprost-d4;34210-11-2;Dinoprost-d9
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SMILES |
CCCCC[C@H](O)/C=C/[C@@H]1[C@H]([C@@H](O)C[C@H]1O)C/C=C\CCCC(O)=O
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InChi Key |
PXGPLTODNUVGFL-YNNPMVKQSA-N
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InChi Code |
InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1
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Chemical Name |
(Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxyoct-1-en-1-yl)cyclopentyl)hept-5-enoic acid
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Synonyms |
Cerviprost HSDB 3315 Panacelan Prostaglandin F2a Prostaglandin F2alpha
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
H2O : ~100 mg/mL (~282.10 mM)
DMSO : ~100 mg/mL (~282.10 mM) |
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Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (7.05 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (7.05 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C,1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution.  (Please use freshly prepared in vivo formulations for optimal results.) |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 2.8210 mL | 14.1052 mL | 28.2103 mL | |
5 mM | 0.5642 mL | 2.8210 mL | 5.6421 mL | |
10 mM | 0.2821 mL | 1.4105 mL | 2.8210 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.