Effects During Pregnancy and Lactation
◉ Overview of Medication Use During Lactation
There is currently no information regarding the use of mepivacaine during lactation. Given the low levels of other local anesthetics in breast milk, a single dose of mepivacaine during lactation is unlikely to have adverse effects on breastfed infants. However, other medications may be preferred, especially when breastfeeding newborns or preterm infants.
Mepivacaine administered to mothers as a local anesthetic during labor has been reported to affect initial breastfeeding behavior in some infants, but not weight gain in the first 5 days postpartum. Although research on mepivacaine is limited, it appears that with good breastfeeding support, epidural local anesthetics, whether or not combined with fentanyl or its derivatives, have little or no adverse effects on breastfeeding success. Labor analgesia may delay the onset of lactation. More research is needed to clarify the impact of mepivacaine use during labor on breastfeeding outcomes.
◉ Effects on Breastfed Infants
As of the revision date, no relevant published information was found.
◉ Effects on Lactation and Breast Milk
A study compared the effects of epidural analgesia using mepivacaine, bupivacaine, and lidocaine during normal labor. The results showed no difference in weight change among the three groups of breastfed infants in the first five days postpartum. Overall weight gain was within the normal range in all groups.
Of the six infants who received mepivacaine pudendal nerve block within one hour before delivery, four started breastfeeding later and had fewer initial milk volumes than 10 infants who did not receive anesthesia during delivery. The long-term consequences of these differences have not been reported.
A national survey of women and their infants from late pregnancy to 12 months postpartum compared the time to lactroogenesis II in mothers who received and did not receive analgesia during labor. Drug categories included: spinal or epidural anesthesia alone, spinal or epidural anesthesia combined with other drugs, and other analgesics alone. Women who received any type of labor analgesia were approximately twice as likely to experience a delay in the second stage of lactation (>72 hours) compared to women who did not receive labor analgesia.

C15H22N2O

246.35

246.173

24358-84-7

Mepivacaine;96-88-8;Mepivacaine hydrochloride;1722-62-9

3032799

Typically exists as solid at room temperature

1.077g/cm3

383.1ºC at 760mmHg

185.5ºC

4.52E-06mmHg at 25°C

1.567

3.313

1

2

2

18

282

1

CN1CCCC[C@H]1C(NC1C(C)=CC=CC=1C)=O

INWLQCZOYSRPNW-ZDUSSCGKSA-N

InChI=1S/C15H22N2O/c1-11-7-6-8-12(2)14(11)16-15(18)13-9-4-5-10-17(13)3/h6-8,13H,4-5,9-10H2,1-3H3,(H,16,18)/t13-/m0/s1

(2S)-N-(2,6-dimethylphenyl)-1-methylpiperidine-2-carboxamide

L(+)-Mepivacaine; Dexivacaina; Dexivacaine

2934.99.9001

Powder      -20°C    3 years

                     4°C     2 years

In solvent   -80°C    6 months

                  -20°C    1 month

Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture and light.

Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

DMSO : ~100 mg/mL (~405.93 mM)

Solubility in Formulation 1: ≥ 2.5 mg/mL (10.15 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL.
Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution.

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Solubility in Formulation 2: ≥ 2.5 mg/mL (10.15 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution.

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Solubility in Formulation 3: ≥ 2.5 mg/mL (10.15 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.

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 (Please use freshly prepared in vivo formulations for optimal results.)