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    Detomidine HCl (MPV 253; MPV253)
    Detomidine HCl (MPV 253; MPV253)

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1108
    CAS #: 90038-01-0Purity ≥98%

    Description: Detomidine HCl (MPV 253; MPV-253), the hydrochloride salt of detomidine, is an alpha2/α2-Adrenoreceptor agonist with sedative properties. It produces dose-dependent sedative and analgesic effects, mediatated by activation of α2 catecholamine receptors. Detomidine is an imidazole derivative and α2-adrenergic agonist, used as a large animal sedative, primarily used in horses. It is usually available as the salt detomidine hydrochloride. It is a prescription medication available to veterinarians sold under the trade name Dormosedan.

    References: Br Vet J. 1996 Nov;152(6):641-57.

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    Molecular Weight (MW)222.71 
    FormulaC12H14N2.HCl 
    CAS No.90038-01-0 
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 45 mg/mL (202.1 mM) 
    Water: 45 mg/mL (202.1 mM) 
    Ethanol: 
    Other info

    Chemical Name: 5-[(2,3-Dimethylphenyl)methyl]-1H-imidazole hydrochloride

    InChi Key: OIWRDXKNDCJZSM-UHFFFAOYSA-N

    InChi Code: InChI=1S/C12H14N2.ClH/c1-9-4-3-5-11(10(9)2)6-12-7-13-8-14-12;/h3-5,7-8H,6H2,1-2H3,(H,13,14);1H

    SMILES Code: CC1=C(C)C(CC2=CN=CN2)=CC=C1.[H]Cl

    SynonymsMPV 253; MPV253; Detomidine hydrochloride; MPV-253; Detomidine HCl; 


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    Detomidine HCl
    Mean (± SE) PCV (A) and TS (B) of healthy horses over time following administration of xylazine IV (clear circle with solid line), romifidine IV (shaded triangle with dotted line), detomidine IV (shaded square with long dashed line), and detomidine. Can Vet J. 2014 Apr; 55(4): 334–340.
     
    Detomidine HCl
    Figure 4 Mean (± SE) splenic thickness measured in ICS 9 of healthy horses over time following administration of xylazine IV (clear circle with solid line), romifidine IV (shaded triangle with dotted line), detomidine IV. Can Vet J. 2014 Apr; 55(4): 334–340.
     
    Detomidine HCl
    Mean (± SE) RBC count (A), COP (B), plasma osmolality (C), and blood glucose concentration (D) of healthy horses over time following administration of xylazine IV (clear circle with solid line), romifidine IV (shaded triangle with dotted line), Can Vet J. 2014 Apr; 55(4): 334–340.


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