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    Decamethonium Bromide
    Decamethonium Bromide

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1202
    CAS #: 541-22-0Purity ≥98%

    Description: Decamethonium bromide (Syncurine; Decamethonum; Lopac-D-1260; (DM)Br2 Syncurine), a quaternary ammonium ion, is a short-acting, depolarizing muscle relaxant and/or neuromuscular blocker used in anesthesia to induce paralysis.  

    References: Br J Anaesth. 2002 May;88(5):692-9.

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    Molecular Weight (MW)418.29 
    FormulaC16H38N2.2Br 
    CAS No.541-22-0 
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 34 mg/mL (81.3 mM) 
    Water: 84 mg/mL (200.8 mM)
    Ethanol: 25 mg/mL (59.8 mM) 
    Solubility (In vivo)

    Chemical Name: trimethyl-[10-(trimethylazaniumyl)decyl]azanium bromide

    InChi Key: HLXQFVXURMXRPU-UHFFFAOYSA-L

    InChi Code: InChI=1S/C16H38N2.2BrH/c1-17(2,3)15-13-11-9-7-8-10-12-14-16-18(4,5)6;;/h7-16H2,1-6H3;2*1H/q+2;;/p-2

    SMILES Code: C[N+](CCCCCCCCCC[N+](C)(C)C)(C)C.[Br-].[Br-]           

    Synonyms

    Syncurine; Decamethonium; Decamethonum; Lopac-D-1260; (DM)Br2


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    In Vitro

    In vitro activity: Decamethonium (Syncurine) is a depolarizing muscle relaxant or neuromuscular blocking agent, and is used in anesthesia to induce paralysis. Decamethonium, which has a short action time, is similar to acetylcholine and acts as a partial agonist of the nicotinic acetylcholine receptor. In the motor endplate, it causes depolarization, preventing further effects to the normal release of acetylcholine from the presynaptic terminal, and therefore preventing the neural stimulus from affecting the muscle. In the process of binding, decamethonium actually activates (depolarizes) the motor endplate, but since the decamethonium itself is not degraded, the membrane remains depolarized and unresponsive to normal acetylcholine release.

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    References

    Br J Anaesth. 2002 May;88(5):692-9. 


    These protocols are for reference only. InvivoChem does not independently validate these methods.

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