Decamethonium Bromide

Alias:
Cat No.:V1202 Purity: ≥98%
Decamethonium bromide (Syncurine; Decamethonum;Lopac-D-1260; (DM)Br2 Syncurine),a quaternary ammonium ion, is a short-acting, depolarizing muscle relaxant and/or neuromuscular blocker used in anesthesia to induce paralysis.
Decamethonium Bromide Chemical Structure CAS No.: 541-22-0
Product category: AChR Receptor
This product is for research use only, not for human use. We do not sell to patients.
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Purity & Quality Control Documentation

Purity: ≥98%

Product Description

Decamethonium bromide (Syncurine; Decamethonum; Lopac-D-1260; (DM)Br2 Syncurine), a quaternary ammonium ion, is a short-acting, depolarizing muscle relaxant and/or neuromuscular blocker used in anesthesia to induce paralysis.

Biological Activity I Assay Protocols (From Reference)
ln Vitro

In vitro activity: Decamethonium (Syncurine) is a depolarizing muscle relaxant or neuromuscular blocking agent, and is used in anesthesia to induce paralysis. Decamethonium, which has a short action time, is similar to acetylcholine and acts as a partial agonist of the nicotinic acetylcholine receptor. In the motor endplate, it causes depolarization, preventing further effects to the normal release of acetylcholine from the presynaptic terminal, and therefore preventing the neural stimulus from affecting the muscle. In the process of binding, decamethonium actually activates (depolarizes) the motor endplate, but since the decamethonium itself is not degraded, the membrane remains depolarized and unresponsive to normal acetylcholine release.

ln Vivo

Animal Protocol


References
Br J Anaesth.2002 May;88(5):692-9.
These protocols are for reference only. InvivoChem does not independently validate these methods.
Physicochemical Properties
Molecular Formula
C16H38N2.2BR
Molecular Weight
418.29
CAS #
541-22-0
SMILES
[Br-].[Br-].[N+](C([H])([H])[H])(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[N+](C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
Synonyms

Syncurine; Decamethonium; Decamethonum;Lopac-D-1260; (DM)Br2

Storage

Powder      -20°C    3 years

                     4°C     2 years

In solvent   -80°C    6 months

                  -20°C    1 month

Shipping Condition
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
Solubility Data
Solubility (In Vitro)
DMSO:34 mg/mL (81.3 mM)
Water:84 mg/mL (200.8 mM)
Ethanol:25 mg/mL (59.8 mM)
Solubility (In Vivo)

Chemical Name: trimethyl-[10-(trimethylazaniumyl)decyl]azanium bromide

InChi Key: HLXQFVXURMXRPU-UHFFFAOYSA-L

InChi Code: InChI=1S/C16H38N2.2BrH/c1-17(2,3)15-13-11-9-7-8-10-12-14-16-18(4,5)6;;/h7-16H2,1-6H3;2*1H/q+2;;/p-2

SMILES Code: C[N+](CCCCCCCCCC[N+](C)(C)C)(C)C.[Br-].[Br-]

 (Please use freshly prepared in vivo formulations for optimal results.)
Preparing Stock Solutions 1 mg 5 mg 10 mg
1 mM 2.3907 mL 11.9534 mL 23.9069 mL
5 mM 0.4781 mL 2.3907 mL 4.7814 mL
10 mM 0.2391 mL 1.1953 mL 2.3907 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.

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Note: Chemical formula is case sensitive: C12H18N3O4  c12h18n3o4
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In vivo Formulation Calculator (Clear solution)
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Calculation results

Working concentration mg/mL;

Method for preparing DMSO stock solution mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation:Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
             (2) Be sure to add the solvent(s) in order.

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