Dabigatran Etexilate

Alias: BIBR 1048; BIBR953; Pradaxa;BIBR1048; BIBR-1048; BIBR 953; BIBR-953; Prazaxa
Cat No.:V1849 Purity: ≥98%
Dabigatran Etexilate(BIBR-1048) is the prodrug of dabigatran used as an thrombin inhibitor to treat blood clot.
Dabigatran Etexilate Chemical Structure CAS No.: 211915-06-9
Product category: Thrombin
This product is for research use only, not for human use. We do not sell to patients.
Size Price Stock Qty
10mg
25mg
50mg
100mg
250mg
500mg
1g
Other Sizes

Other Forms of Dabigatran Etexilate:

  • Dabigatran (BIBR 953)
  • Dabigatran etexilate mesylate
  • Dabigatran ethyl ester
  • BIBR 1087 SE
Official Supplier of:
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Purity & Quality Control Documentation

Purity: ≥98%

Product Description

Dabigatran Etexilate (BIBR-1048) is the prodrug of dabigatran used as an thrombin inhibitor to treat blood clot. It is a potent and nonpeptidic small molecule that binds to the active site of thrombin to specifically and reversibly inhibit thrombin both free and bound to clots. A powerful nonpeptide thrombin inhibitor, dabigatran (also called IBR 953) has an IC50 of 9.3 nM in a cell-free assay. Dabigatran's highly polar, zwitterionic nature and poor oral absorption make it intended to be transformed into an orally active prodrug, BIBR 1048. A competitive inhibition of thrombin is observed with dabigatran.

Biological Activity I Assay Protocols (From Reference)
Targets
Thrombin
ln Vitro
Dabigatran selectively and reversibly inhibits the thrombin-induced platelet aggregation (IC50: 10 nM) and human thrombin (Ki: 4.5 nM), but it has no inhibitory effect on other agents that stimulate platelets. Dabigatran selectively and reversibly inhibits the thrombin-induced platelet aggregation (IC50: 10 nM) and human thrombin (Ki: 4.5 nM), but it has no inhibitory effect on other agents that stimulate platelets. With an IC50 of 0.56 μM, dabigatran inhibits the production of thrombin in platelet-poor plasma (PPP), as determined by the endogenous thrombin potential (ETP). At 0.23, 0.83, and 0.18 μM, respectively, dabigatran doubles the activated partial thromboplastin time (aPTT), prothrombin time (PT), and ecarin clotting time (ECT) in human PPP. Dabigatran exhibits concentration-dependent anticoagulant effects in a variety of species in vitro.[1]
ln Vivo
Dabigatran extends the aPTT in rats (0.3, 1 and 3 mg/kg) and rhesus monkeys (0.15, 0.3 and 0.6 mg/kg) in a dose-dependent manner following intravenous administration. (Source: ) In comparison to enoxaparin, dabigatran etexilate (20 mg/kg) causes less prolongation of the K value, as well as less decreases in angle and maximum amplitude in swine. [/2] The dose-dependent reduction of thrombus formation by dabigatran (0.01-0.1 mg/kg) has an ED50 (50% of the effective dose) of 0.033 mg/kg and complete inhibition at 0.1 mg/kg. The dose- and time-dependent inhibition of thrombus formation by dabigatran etexilate (5-30 mg/kg) reaches its maximum within 30 minutes of pretreatment, indicating a quick onset of action. [/3]
Animal Protocol
Male rats (280-350 g) and rhesus monkeys of either sex (3-8 kg)
10, 20 and 50 mg/kg for rats and 1, 2.5 and 5 mg/kg for monkeys
Oral
References

[1]. Thromb Haemost . 2007 Jul;98(1):155-62.

[2]. J Thorac Cardiovasc Surg . 2011 Jun;141(6):1410-6.

[3]. Thromb Haemost . 2007 Aug;98(2):333-8.

These protocols are for reference only. InvivoChem does not independently validate these methods.
Physicochemical Properties
Molecular Formula
C34H41N7O5
Molecular Weight
627.73
Exact Mass
627.32
Elemental Analysis
C, 65.05; H, 6.58; N, 15.62; O, 12.74)
CAS #
211915-06-9
Appearance
Solid powder
SMILES
CCCCCCOC(=O)NC(=N)C1=CC=C(C=C1)NCC2=NC3=C(N2C)C=CC(=C3)C(=O)N(CCC(=O)OCC)C4=CC=CC=N4.CS(=O)(=O)O
InChi Key
XETBXHPXHHOLOE-UHFFFAOYSA-N
InChi Code
InChI=1S/C34H41N7O5.CH4O3S/c1-4-6-7-10-21-46-34(44)39-32(35)24-12-15-26(16-13-24)37-23-30-38-27-22-25(14-17-28(27)40(30)3)33(43)41(20-18-31(42)45-5-2)29-11-8-9-19-36-29;1-5(2,3)4/h8-9,11-17,19,22,37H,4-7,10,18,20-21,23H2,1-3H3,(H2,35,39,44);1H3,(H,2,3,4)
Chemical Name
ethyl 3-[[2-[[4-(N-hexoxycarbonylcarbamimidoyl)anilino]methyl]-1-methylbenzimidazole-5-carbonyl]-pyridin-2-ylamino]propanoate;methanesulfonic acid
Synonyms
BIBR 1048; BIBR953; Pradaxa;BIBR1048; BIBR-1048; BIBR 953; BIBR-953; Prazaxa
HS Tariff Code
2934.99.9001
Storage

Powder      -20°C    3 years

                     4°C     2 years

In solvent   -80°C    6 months

                  -20°C    1 month

Shipping Condition
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
Solubility Data
Solubility (In Vitro)
DMSO: ~126 mg/mL (~200.7 mM)
Water: <1 mg/mL
Ethanol: ~12 mg/mL (~19.1 mM)
Preparing Stock Solutions 1 mg 5 mg 10 mg
1 mM 1.5930 mL 7.9652 mL 15.9304 mL
5 mM 0.3186 mL 1.5930 mL 3.1861 mL
10 mM 0.1593 mL 0.7965 mL 1.5930 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.

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Working concentration mg/mL;

Method for preparing DMSO stock solution mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation:Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
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Clinical Trial Information
NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04695106 Recruiting Drug: Ticagrelor
Drug: Dabigatran Etexilate
Atrial Fibrillation
Antithrombotic Therapy
Medical University of Gdansk October 25, 2021 Phase 4
NCT03539055 Active
Recruiting
Drug: Dabigatran Etexilate
Oral Capsule
Atrial Fibrillation
Vanderbilt University Medical
Center
Vanderbilt University Medical
Center
September 1, 2018 Phase 4
NCT04045093 Recruiting Drug: Dabigatran etexilate
Drug: Warfarin
Atrial Fibrillation
Mitral Stenosis
The University of Hong Kong October 22, 2020 Phase 4
NCT05536791 Recruiting Drug: Dabigatran Etexilate
(DE)
Venous Thromboembolism Boehringer Ingelheim November 24, 2022
NCT05715658 Recruiting Drug: Dabigatran etexilate
capsule
Nonvalvular Atrial Fibrillation
Health, Subjective
Dongyang Liu August 15, 2022 Not Applicable
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