| Size | Price | Stock | Qty |
|---|---|---|---|
| 5g |
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| Other Sizes |
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| ln Vitro |
Various d-amino acids, such as D-serine, D-aspartic acid (D-Asp) and D-glutamic acid (D-Glu), are commonly prevalent in animals including humans and are currently considered unique Physiologically active compounds and/or biomarkers [1]. D-[Asp/Glu] (4 mg/mL) suppresses the binding of IgE to peanut (75%), but D-Glu and D-Asp show no inhibitory effect. IgE is specific for D-[Asp/Glu] and may have the potential to eliminate IgE or diminish IgE binding to peanut allergen [2].
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|---|---|
| ln Vivo |
At the moment, D-glutamate is being studied as a regulator of hormone secretion and neuronal transmission. D-aspartate oxidase is the only enzyme that metabolizes it in mammals [1]. Following intraperitoneal administration, D-glutamate is transformed into n-pyrrolidone carboxylic acid, while L-glutamate is catabolized by α-ketoglutarate. In the cecum, the methyl carbon of acetate is created from the carbon 2 of D- and L-glutamic acid. The transformation of D-glutamic acid into n-pyrrolidone carboxylic acid is catalyzed by the kidney and liver of rats [3].
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| References | |
| Additional Infomation |
D-glutamic acid is an optically active form of glutamic acid having D-configuration. It has a role as an Escherichia coli metabolite and a mouse metabolite. It is a D-alpha-amino acid and a glutamic acid. It is a conjugate acid of a D-glutamate(1-). It is an enantiomer of a L-glutamic acid.
Glutamic acid is the most common excitatory neurotransmitter in the central nervous system. D-Glutamic acid is a metabolite found in or produced by Escherichia coli (strain K12, MG1655). D-glutamic acid has been reported in Pisum sativum with data available. A non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in the CENTRAL NERVOUS SYSTEM. See also: Glutamic Acid (annotation moved to); Glutamic Acid Hydrochloride (annotation moved to). |
| Molecular Formula |
C5H9NO4
|
|---|---|
| Molecular Weight |
147.1293
|
| Exact Mass |
147.053
|
| CAS # |
6893-26-1
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| Related CAS # |
D-Glutamic acid-d5;14341-88-9
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| PubChem CID |
23327
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| Appearance |
White to off-white solid powder
|
| Density |
1.4±0.1 g/cm3
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| Boiling Point |
333.8±32.0 °C at 760 mmHg
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| Melting Point |
200-202ºC
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| Flash Point |
155.7±25.1 °C
|
| Vapour Pressure |
0.0±1.5 mmHg at 25°C
|
| Index of Refraction |
1.522
|
| LogP |
-1.43
|
| Hydrogen Bond Donor Count |
3
|
| Hydrogen Bond Acceptor Count |
5
|
| Rotatable Bond Count |
4
|
| Heavy Atom Count |
10
|
| Complexity |
145
|
| Defined Atom Stereocenter Count |
1
|
| SMILES |
C(CC(=O)O)[C@H](C(=O)O)N
|
| InChi Key |
WHUUTDBJXJRKMK-GSVOUGTGSA-N
|
| InChi Code |
InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1
|
| Chemical Name |
(2R)-2-aminopentanedioic acid
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
H2O : ~13 mg/mL (~88.36 mM)
DMSO :< 1 mg/mL |
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 10 mg/mL (67.97 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication (<60°C).
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 6.7967 mL | 33.9836 mL | 67.9671 mL | |
| 5 mM | 1.3593 mL | 6.7967 mL | 13.5934 mL | |
| 10 mM | 0.6797 mL | 3.3984 mL | 6.7967 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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