Size | Price | Stock | Qty |
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50mg |
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100mg |
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250mg |
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500mg |
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1g |
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2g |
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5g |
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Other Sizes |
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Purity: ≥98%
Cytisine (Baphitoxine,Sophorine; Citizin; HSDB-3560; Laburnin; NSC-407282; Cytisinicline), a nicotinic acetylcholine receptor agonist, is a naturally occuring alkaloid found in several plant genera, such as Laburnum and Cytisus of the family Fabaceae. It has been used medically to help with smoking cessation. It is a potent agonist selective for neuronal nAChRs (Ki = 2, 5890, 480, 329, and 492 nM at α4β2, α7, α3β4, α6/α4β4, α1β1γδ, respectively).
ln Vitro |
In HepG2 cells, cytosinicline (Cytisine) at 2.5, 5 and 10 mM can cause apoptosis [4]. Phase G1 (P<0.01). The population of sub-G1 cells is greatly increased when HepG2 cells are preincubated with Cytisinicline (Cytisine) at concentrations of 2.5, 5, and 10 mM [4].
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ln Vivo |
Compared to those receiving vehicle, individuals on cytisinicline (5 mg/kg, ip) ate less and gained less weight [2]. Animals self-administered Cytisine substantially less than nicotine, and total particle intake rose with Cytisinicline (Cytisine) substitution compared with nicotine [2].
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Animal Protocol |
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References |
[1]. Pabreza LA, et al. [3H]cytisine binding to nicotinic cholinergic receptors in brain. Mol Pharmacol. 1991 Jan;39(1):9-12.
[2]. Grebenstein PE, et al. The effects of noncontingent and self-administered cytisine on body weight and meal patterns in male Sprague-Dawley rats. Pharmacol Biochem Behav. 2013 Sep;110:192-200. [3]. Walker N, et al. Cytisine versus nicotine for smoking cessation. N Engl J Med. 2014 Dec 18;371(25):2353-62. [4]. Yu L, et al. Cytisine induces endoplasmic reticulum stress caused by calcium overload in HepG2 cells. Oncol Rep. 2018 Mar;39(3):1475-1484. |
Molecular Formula |
C11H14N2O
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Molecular Weight |
190.24
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CAS # |
485-35-8
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SMILES |
O=C1C([H])=C([H])C([H])=C2[C@@]3([H])C([H])([H])N([H])C([H])([H])[C@@]([H])(C([H])([H])N21)C3([H])[H]
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InChi Key |
ANJTVLIZGCUXLD-DTWKUNHWSA-N
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InChi Code |
InChI=1S/C11H14N2O/c14-11-3-1-2-10-9-4-8(5-12-6-9)7-13(10)11/h1-3,8-9,12H,4-7H2/t8-,9+/m0/s1
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Chemical Name |
(1R,5S)-1,2,3,4,5,6-hexahydro-8H-1,5-methanopyrido[1,2-a][1,5]diazocin-8-one
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Synonyms |
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
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Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
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Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 5.2565 mL | 26.2826 mL | 52.5652 mL | |
5 mM | 1.0513 mL | 5.2565 mL | 10.5130 mL | |
10 mM | 0.5257 mL | 2.6283 mL | 5.2565 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.