| Size | Price | Stock | Qty |
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| 50mg |
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| 100mg |
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| 250mg |
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| 500mg |
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| 1g |
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| Other Sizes |
Purity: ≥98%
Clorprenaline HCl (NSC-334693; NSC334693; NSC 334693), the hydrochloride salt of Clorprenaline, is a potent β2-receptor agonist used as a bronchodilator with a significant expansion of the bronchial effect.
| Targets |
β2-receptor
β2-adrenoceptor (agonist) [3] |
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|---|---|---|
| ln Vitro |
In vitro activity: In a single chromatographic run, the linear ranges for cleprenaline are 8.0-1.6 ×10 3 ng/mL, and the detection limits are 3.0 ng/mL. [1] A bronchodilator with affinity-interaction or separation by CE with charged CD-CZE sulfobuthylether (SBE)-β-CD or β-CD-phosphate with resolution greater than 1.2 is cleprenaline. The ideal separation condition for cleprenaline is 60 mM HP-β-CD.[2] The three primary ingredients of a clorprenaline compound tablet are cleprenaline hydrochloride (a), bromhexine hydrochloride (b), and decloxizine hydrochloride (c).[3]
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| ln Vivo |
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| Animal Protocol |
Rat pharmacokinetic study: Adult male rats are fasted for 12 hours before oral administration of Clorprenaline HCl (20 mg/kg) dissolved in physiological saline. Blood samples are collected via orbital venous plexus at 0.5, 1, 2, 4, 6, 8, and 12 hours post-dosing. Plasma is separated and analyzed for clorprenaline concentration using high-performance liquid chromatography (HPLC) [3]
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| ADME/Pharmacokinetics |
Absorption: Chronaline hydrochloride is well absorbed in rats after oral administration, reaching peak plasma concentration (Cmax) 1-2 hours after administration [3]
Metabolism: It is mainly metabolized in the liver through hydroxylation and conjugation reactions, producing inactive metabolites [3] Excretion: Approximately 60-70% of the oral dose is excreted in the urine within 24 hours, of which approximately 20% is the original drug [3] Elimination half-life: The elimination half-life (t1/2) in rat plasma is approximately 3.5 hours [3] |
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| References | ||
| Additional Infomation |
Cloprenaline hydrochloride is the hydrochloride form of cloprenaline, a β2-adrenergic agonist with bronchodilatory effects. Cloprenaline selectively binds to and activates β2-adrenergic receptors on the smooth muscle of the bronchioles, thereby stimulating the activity of adenylate cyclase. Adenylate cyclase is an enzyme that catalyzes the conversion of adenosine triphosphate (ATP) to cyclic adenosine monophosphate (cAMP). Increased intracellular cAMP levels lead to bronchial smooth muscle relaxation. This can increase airflow, prevent bronchospasm, and potentially ultimately improve airway function.
Chronaline hydrochloride is a selective β2-adrenergic receptor agonist with bronchodilatory effects[3] Its mechanism of action is to activate β2-adrenergic receptors in bronchial smooth muscle, thereby leading to muscle relaxation and relief of bronchospasm[3] Based on its bronchodilatory effect, it is clinically used to treat symptoms of bronchial asthma and chronic obstructive pulmonary disease (COPD)[3] Due to its good in vivo absorption properties, this drug is suitable for oral administration[3] |
| Molecular Formula |
C11H17CL2NO
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|---|---|---|
| Molecular Weight |
250.16
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| Exact Mass |
267.079
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| Elemental Analysis |
C, 52.81; H, 6.85; Cl, 28.34; N, 5.60; O, 6.40
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| CAS # |
6933-90-0
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| Related CAS # |
3811-25-4; 6933-90-0 (hydrochloride)
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| PubChem CID |
23360
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| Appearance |
White to off-white solid powder
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| Boiling Point |
329.7ºC at 760 mmHg
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| Melting Point |
165-169ºC
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| Flash Point |
153.2ºC
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| LogP |
3.564
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| Hydrogen Bond Donor Count |
3
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| Hydrogen Bond Acceptor Count |
2
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| Rotatable Bond Count |
4
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| Heavy Atom Count |
15
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| Complexity |
163
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| Defined Atom Stereocenter Count |
0
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| SMILES |
ClC1=C([H])C([H])=C([H])C([H])=C1C([H])(C([H])([H])N([H])C([H])(C([H])([H])[H])C([H])([H])[H])O[H].Cl[H]
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| InChi Key |
CPCPUCRSKRHVAH-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C11H16ClNO.ClH/c1-8(2)13-7-11(14)9-5-3-4-6-10(9)12;/h3-6,8,11,13-14H,7H2,1-2H3;1H
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| Chemical Name |
1-(2-chlorophenyl)-2-(propan-2-ylamino)ethanol;hydrochloride
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| Synonyms |
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
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| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
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| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (9.99 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (9.99 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (9.99 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. Solubility in Formulation 4: 100 mg/mL (399.74 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with ultrasonication. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.9974 mL | 19.9872 mL | 39.9744 mL | |
| 5 mM | 0.7995 mL | 3.9974 mL | 7.9949 mL | |
| 10 mM | 0.3997 mL | 1.9987 mL | 3.9974 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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