Clobetasol propionate

Alias: CGP 9555; CCl 4725; CGP-9555; CCl-4725;CGP9555; CCl4725;Clobex Cosvate; Temovate; Olux Tenovate Dermovate; Dermatovate; Butavate; Movate Novate.
Cat No.:V1714 Purity: ≥98%
Clobetasol propionate (formerly CGP-9555, CCl-4725; CGP9555; CCl4725;Clobex Cosvate; Temovate; Olux Tenovate) is a topical corticosteroid used as an anti-inflammatoryfor treatment of various skin disorders including eczema and psoriasis.
Clobetasol propionate Chemical Structure CAS No.: 25122-46-7
Product category: Calcium Channel
This product is for research use only, not for human use. We do not sell to patients.
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Purity & Quality Control Documentation

Purity: ≥98%

Product Description

Clobetasol propionate (formerly CGP-9555, CCl-4725; CGP9555; CCl4725; Clobex Cosvate; Temovate; Olux Tenovate) is a topical corticosteroid used as an anti-inflammatory for treatment of various skin disorders including eczema and psoriasis.

Biological Activity I Assay Protocols (From Reference)
ln Vitro
Clobetasol propionate has an IC50 of 15.6 μM against CYP3A4[1]. Clobetasol propionate (1 μM; 24 hours) did not raise the levels of CYP3A4 protein, but it preferentially inhibits CYP3A5. No cell lines (AsPC-1 wild type (WT), CYP3A5 overexpressing AsPC-1CYP3A5–/– cells ("3A5–/– + 3A5OE” cells), and AsPC-1CYP3A5–/– CYP3A4–overexpressing cells ("3A5–/– + 3A4OE” cells) were affected by clobetasol propionate [1].
ln Vivo
In a transplant SCID mouse model of human psoriatic skin, clobetasol propionate (topically administered; applied daily for 14 days) decreased epidermal thickness in both normal and psoriatic skin [3].
References
[1]. William C Wright, et al. Clobetasol Propionate Is a Heme-Mediated Selective Inhibitor of Human Cytochrome P450 3A5. J Med Chem. 2020 Feb 13;63(3):1415-1433.
[2]. Steven R Feldman, et al. Topical clobetasol propionate in the treatment of psoriasis: a review of newer formulations. Am J Clin Dermatol. 2009;10(6):397-406.
[3]. M Zeigler, et al. Anti-CD11a ameliorates disease in the human psoriatic skin-SCID mouse transplant model: comparison of antibody to CD11a with Cyclosporin A and clobetasol propionate. Lab Invest. 2001 Sep;81(9):1253-61.
These protocols are for reference only. InvivoChem does not independently validate these methods.
Physicochemical Properties
Molecular Formula
C25H32CLFO5
Molecular Weight
466.97
CAS #
25122-46-7
SMILES
ClC([H])([H])C([C@]1([C@@]([H])(C([H])([H])[H])C([H])([H])[C@@]2([H])[C@]3([H])C([H])([H])C([H])([H])C4=C([H])C(C([H])=C([H])[C@]4(C([H])([H])[H])[C@]3([C@]([H])(C([H])([H])[C@@]21C([H])([H])[H])O[H])F)=O)OC(C([H])([H])C([H])([H])[H])=O)=O
InChi Key
FKWXHUWJFNMNSE-NQNWYGNOSA-N
InChi Code
InChI=1S/C25H32ClFO5/c1-5-21(31)32-23(4)14(2)10-18-17-7-6-15-11-16(28)8-9-22(15,3)25(17,27)19(29)12-24(18,23)20(30)13-26/h8-9,11,14,17-19,29H,5-7,10,12-13H2,1-4H3/t14-,17-,18-,19-,22-,23+,24-,25-/m0/s1
Chemical Name
(8S,9R,10S,11S,13R,14S,16S,17R)-13-(2-chloroacetyl)-9-fluoro-11-hydroxy-10,16,17-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl propionate
Synonyms
CGP 9555; CCl 4725; CGP-9555; CCl-4725;CGP9555; CCl4725;Clobex Cosvate; Temovate; Olux Tenovate Dermovate; Dermatovate; Butavate; Movate Novate.
Storage

Powder      -20°C    3 years

                     4°C     2 years

In solvent   -80°C    6 months

                  -20°C    1 month

Shipping Condition
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
Solubility Data
Solubility (In Vitro)
DMSO:93 mg/mL (199.2 mM)
Water:<1 mg/mL
Ethanol:20 mg/mL (42.8 mM)
Preparing Stock Solutions 1 mg 5 mg 10 mg
1 mM 2.1415 mL 10.7073 mL 21.4147 mL
5 mM 0.4283 mL 2.1415 mL 4.2829 mL
10 mM 0.2141 mL 1.0707 mL 2.1415 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.

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Method for preparing DMSO stock solution mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

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