| Size | Price | Stock | Qty |
|---|---|---|---|
| 250mg |
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| 500mg |
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| Other Sizes |
| References |
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|---|---|
| Additional Infomation |
Citicoline is the choline donor in the biosynthesis of choline phosphate glycerol. It has been investigated for the treatment, supportive care, and diagnosis of conditions such as mania, stroke, hypomania, cocaine abuse, and bipolar disorder. Citicoline is a nutritional supplement and a source of choline and cytidine, possessing potential neuroprotective and nootropic effects. Also known as cytidine-5-bisphosphate choline or CDP-choline, it is hydrolyzed in the intestine to cytidine and choline. After absorption, both cytidine and choline are dispersed and used in various biosynthetic pathways, crossing the blood-brain barrier to resynthesize citicoline in the brain, where it is the rate-limiting product of phosphatidylcholine synthesis. This drug can also increase the levels of acetylcholine (ACh), norepinephrine (NE), and dopamine in the central nervous system (CNS). Furthermore, citicoline participates in the preservation of sphingomyelin and cardiolipin, as well as the restoration of Na+/K+-ATPase activity. Citicoline can also increase glutathione synthesis and glutathione reductase activity, and exert an anti-apoptotic effect. Citicoline is a choline donor in the biosynthesis of choline phosphate glycerols.
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| Molecular Formula |
C14H25N4NAO11P2
|
|---|---|
| Molecular Weight |
510.3
|
| Exact Mass |
510.089
|
| CAS # |
33818-15-4
|
| Related CAS # |
Citicoline;987-78-0;Citicoline-d9 sodium
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| PubChem CID |
36605
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| Appearance |
White to off-white solid powder
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| Melting Point |
259-268°C (dec.)
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| Hydrogen Bond Donor Count |
3
|
| Hydrogen Bond Acceptor Count |
11
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| Rotatable Bond Count |
10
|
| Heavy Atom Count |
32
|
| Complexity |
813
|
| Defined Atom Stereocenter Count |
4
|
| SMILES |
C[N+](C)(C)CCOP(=O)([O-])OP(=O)([O-])OC[C@@H]1[C@H]([C@H]([C@@H](O1)N2C=CC(=NC2=O)N)O)O.[Na+]
|
| InChi Key |
YWAFNFGRBBBSPD-OCMLZEEQSA-M
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| InChi Code |
InChI=1S/C14H26N4O11P2.Na/c1-18(2,3)6-7-26-30(22,23)29-31(24,25)27-8-9-11(19)12(20)13(28-9)17-5-4-10(15)16-14(17)21;/h4-5,9,11-13,19-20H,6-8H2,1-3H3,(H3-,15,16,21,22,23,24,25);/q;+1/p-1/t9-,11-,12-,13-;/m1./s1
|
| Chemical Name |
sodium;[[(2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl] 2-(trimethylazaniumyl)ethyl phosphate
|
| Synonyms |
Citicolinesodium; Citicoline Na; Citicoline Sodium
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| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
H2O : ≥ 100 mg/mL (~195.96 mM)
DMSO : ~1 mg/mL (~1.96 mM) |
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 100 mg/mL (195.96 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.9596 mL | 9.7982 mL | 19.5963 mL | |
| 5 mM | 0.3919 mL | 1.9596 mL | 3.9193 mL | |
| 10 mM | 0.1960 mL | 0.9798 mL | 1.9596 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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