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    Cisatracurium Besylate (51W89)
    Cisatracurium Besylate (51W89)

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1144
    CAS #: 96946-42-8Purity ≥98%

    Description: Cisatracurium Besylate (51W89; Nimbex; 51 W89; 51-W89; Cisatracurium besilat), the Besylate salt of Cisatracurium, is a nondepolarizing neuromuscular blocking agent with anesthetic effects. It antagonizes the action of acetylcholine by inhibiting neuromuscular transmission. Cisatracurium is used adjunctively in anesthesia to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation. Cisatracurium is one of the ten isomers of the parent molecule, atracurium. Moreover, cisatracurium represents approximately 15% of the atracurium mixture. 

    References: J Sep Sci. 2015 Jul;38(13):2332-9; Minerva Anestesiol. 2013 Nov;79(11):1238-47. 

    Related CAS #: 96946-42-8 (besylate); 96946-41-7 (cation)    

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    Molecular Weight (MW)1243.48 
    FormulaC53H72N2O12.2C6H5O3S 
    CAS No.96946-42-8 
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 249 mg/mL (200.2 mM)
    Water: 47 mg/mL (37.8 mM)
    Ethanol: 249 mg/mL (200.2 mM)
    Other info

    Chemical Name: (1R,1'R,2R,2'R)-2,2'-((pentane-1,5-diylbis(oxy))bis(3-oxopropane-3,1-diyl))bis(1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-2-ium) benzenesulfonate

    InChi Key: XXZSQOVSEBAPGS-DONVQRBFSA-L

    InChi Code: InChI=1S/C53H72N2O12.2C6H6O3S/c1-54(22-18-38-32-48(62-7)50(64-9)34-40(38)42(54)28-36-14-16-44(58-3)46(30-36)60-5)24-20-52(56)66-26-12-11-13-27-67-53(57)21-25-55(2)23-19-39-33-49(63-8)51(65-10)35-41(39)43(55)29-37-15-17-45(59-4)47(31-37)61-6;2*7-10(8,9)6-4-2-1-3-5-6/h14-17,30-35,42-43H,11-13,18-29H2,1-10H3;2*1-5H,(H,7,8,9)/q+2;;/p-2/t42-,43-,54-,55-;;/m1../s1

    SMILES Code: O=C(OCCCCCOC(CC[[email protected]+]1(C)[[email protected]](CC2=CC=C(OC)C(OC)=C2)C3=C(C=C(OC)C(OC)=C3)CC1)=O)CC[[email protected]+]4(C)[[email protected]](CC5=CC=C(OC)C(OC)=C5)C6=C(C=C(OC)C(OC)=C6)CC4.O=S(C7=CC=CC=C7)([O-])=O.O=S(C8=CC=CC=C8)([O-])=O

    Synonyms

    51-W89; Nimbex; 51 W89; 51W89; Cisatracurium besilat


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    Cisatracurium Besylate
    Cisatracurium triggers excessive mitochondrial autophagy in a dose- and time-dependent manner in mammalian cells. Int J Mol Sci. 2016 Apr; 17(4): 515.
     
    Cisatracurium Besylate
    Cisatracurium causes inhibition of cell proliferation and induction of cell death. Int J Mol Sci. 2016 Apr; 17(4): 515.
    Cisatracurium Besylate
    Inhibition of cell proliferation and induction of cell death by cisatracurium is blocked in ATG5-deficient cells. Int J Mol Sci. 2016 Apr; 17(4): 515.


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