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    Cinepazide maleate (MD-67350)
    Cinepazide maleate (MD-67350)

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    This product is for research use only, not for human use. We do not sell to patients.
    Number: - + Pieces(InventoryPieces)
    InvivoChem Cat #: V1258
    CAS #: 26328-04-1Purity ≥98%

    Description: Cinepazide maleate (NSC291562; MD-67350; MD67350; Brendil; Vasodistal; Kelinao or Anjieli), the maleate salt form of cinepazide,is a vasodilator used in China for the treatment of cardiovascular, cerebrovascular, and peripheral vascular diseases. It was reported to work by potentiating A2 adenosine receptors.

    References: Nihon Yakurigaku Zasshi. 1979 Jul;75(5):507-16; Jpn J Pharmacol. 1986 May;41(1):109-15.

    Related CAS #: 23887-46-9 (free base)   88197-48-2 (mesylate)   26328-04-1 (maleate)  

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    • 香港大学
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    Molecular Weight (MW)533.57 
    CAS No.26328-04-1 
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 107 mg/mL (200.5 mM) 
    Water: 107 mg/mL (200.5 mM) 
    Ethanol: <1 mg/mL
    Other info

    Chemical Name: 1-[(1-Pyrrolidinylcarbonyl)methyl]-4-(3,4,5-trimethoxycinnamoyl)piperazine Maleate


    InChi Code: InChI=1S/C22H31N3O5.C4H4O4/c1-28-18-14-17(15-19(29-2)22(18)30-3)6-7-20(26)25-12-10-23(11-13-25)16-21(27)24-8-4-5-9-24;5-3(6)1-2-4(7)8/h6-7,14-15H,4-5,8-13,16H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b7-6+;2-1-

    SMILES Code: O=C(N1CCN(CC(N2CCCC2)=O)CC1)/C=C/C3=CC(OC)=C(OC)C(OC)=C3.O=C(O)/C=C\C(O)=O   


    NSC-291562; Cinepazide maleate; Cinepazide; MD 67350; NSC 291562; NSC291562; MD-67350; MD67350; Brendil; Vasodistal

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    In Vitro

    In vitro activity: Cinepazide maleate is a maleate salt form of cinepazide which is a vasodilator. Cinepazide (30 mg/kg, i.v.) potentiated the vertebral vasodilator response of dogs to intravertebral adenosine and cyclic AMP

    In VivoCinepazide (3 mg/kg -30 mg/kg, i.v.) produces a dose-related and transient increase in vertebral, carotid, renal and femoral arterial flow as well as cardiac output and a decrease in total peripheral resistance in anesthetized dogs. Cinepazide exerts positive inotropic and chronotropic actions. Cinepazide (30 mg/kg, i.v.) potentiates the vertebral vasodilator response of dogs to intravertebral adenosine and cyclic AMP. Intravertebral cinepazide (1 mg -10 mg) increases vertebral blood flow in a dose-related manner and the effect is partially inhibited by intravenous pretreatment with aminophylline but not by pretreatment with autonomic antagonists. Cinepazide is well absorbed and more than 60% of the dose is excreted within 24 hours. In 5 days, rats, dogs, and man excretes in the urine and faeces respectively 36.7% and 58.3%, 33.4% and 68.6%, and 61.3% and 38.1% dose. Cinepazide at doses of 1 mg/kg - 3 mg/kg i.v. decreases systemic blood pressure by 4% and reflexly increases heart rate by 8%. Cinepazide selectively stimulates the functional activities of 5-HT neurons in the brain, which are depressed by hypoxia.
    Animal modelMale Wistar rats
    Formulation & DosageDissolved in saline; 4 mg/kg, 20 mg/kg, 100 mg/kg and 150 mg/kg; i.p. injection

    Nihon Yakurigaku Zasshi. 1979 Jul;75(5):507-16; Jpn J Pharmacol. 1986 May;41(1):109-15. 

    These protocols are for reference only. InvivoChem does not independently validate these methods.


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