My cart
In the shopping cart is not goods, to choose and buy!
  • Product Name
  • Size
  • Quantity
  • Amount
    Selected items : 0 pieces Total : CHECK OUT()
    Cinepazide maleate (MD-67350)
    Cinepazide maleate (MD-67350)

    Price:
    Market Price:

    This product is for research use only, not for human use. We do not sell to patients.
    Number: - + Pieces(InventoryPieces)
    InvivoChem Cat #: V1258
    CAS #: 26328-04-1Purity ≥98%

    Description: Cinepazide maleate (NSC291562; MD-67350; MD67350; Brendil; Vasodistal; Kelinao or Anjieli), the maleate salt form of cinepazide,is a vasodilator used in China for the treatment of cardiovascular, cerebrovascular, and peripheral vascular diseases. It was reported to work by potentiating A2 adenosine receptors.

    References: Nihon Yakurigaku Zasshi. 1979 Jul;75(5):507-16; Jpn J Pharmacol. 1986 May;41(1):109-15.

    Related CAS #: 23887-46-9 (free base)   88197-48-2 (mesylate)   26328-04-1 (maleate)  

    Customer Validation
    Official Supplier of
    • VE
    • OF
    • YALE
    • hhmi
    • 香港大学
    Related Products
    Publications Citing InvivoChem Products
    • Physicochemical and Storage Information
    • Protocol
    • Quality Control Documentation
    • Related Biological Data
    • Customer Review
    Molecular Weight (MW)533.57 
    FormulaC22H31N3O5.C4H4O4 
    CAS No.26328-04-1 
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 107 mg/mL (200.5 mM) 
    Water: 107 mg/mL (200.5 mM) 
    Ethanol: <1 mg/mL
    Other info

    Chemical Name: 1-[(1-Pyrrolidinylcarbonyl)methyl]-4-(3,4,5-trimethoxycinnamoyl)piperazine Maleate

    InChi Key: XSTJTOKYCAJVMJ-GVTSEVKNSA-N

    InChi Code: InChI=1S/C22H31N3O5.C4H4O4/c1-28-18-14-17(15-19(29-2)22(18)30-3)6-7-20(26)25-12-10-23(11-13-25)16-21(27)24-8-4-5-9-24;5-3(6)1-2-4(7)8/h6-7,14-15H,4-5,8-13,16H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b7-6+;2-1-

    SMILES Code: O=C(N1CCN(CC(N2CCCC2)=O)CC1)/C=C/C3=CC(OC)=C(OC)C(OC)=C3.O=C(O)/C=C\C(O)=O   

    Synonyms

    NSC-291562; Cinepazide maleate; Cinepazide; MD 67350; NSC 291562; NSC291562; MD-67350; MD67350; Brendil; Vasodistal


    • Molarity Calculator
    • Dilution Calculator
    • The molarity calculator equation

      Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

      • Mass
      • Concentration
      • Volume
      • Molecular Weight *
      • =
      • ×
      • ×
    • The dilution calculator equation

      Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

      This equation is commonly abbreviated as: C1V1 = C2V2

      • Concentration (start)
      • ×
      • Volume (start)
      • =
      • Concentration (final)
      • ×
      • Volume (final)
      • ×
      • =
      • ×
      • C1
      •  
      • V1
      •  
      • C2
      •  
      • V2
    In Vitro

    In vitro activity: Cinepazide maleate is a maleate salt form of cinepazide which is a vasodilator. Cinepazide (30 mg/kg, i.v.) potentiated the vertebral vasodilator response of dogs to intravertebral adenosine and cyclic AMP

    In VivoCinepazide (3 mg/kg -30 mg/kg, i.v.) produces a dose-related and transient increase in vertebral, carotid, renal and femoral arterial flow as well as cardiac output and a decrease in total peripheral resistance in anesthetized dogs. Cinepazide exerts positive inotropic and chronotropic actions. Cinepazide (30 mg/kg, i.v.) potentiates the vertebral vasodilator response of dogs to intravertebral adenosine and cyclic AMP. Intravertebral cinepazide (1 mg -10 mg) increases vertebral blood flow in a dose-related manner and the effect is partially inhibited by intravenous pretreatment with aminophylline but not by pretreatment with autonomic antagonists. Cinepazide is well absorbed and more than 60% of the dose is excreted within 24 hours. In 5 days, rats, dogs, and man excretes in the urine and faeces respectively 36.7% and 58.3%, 33.4% and 68.6%, and 61.3% and 38.1% dose. Cinepazide at doses of 1 mg/kg - 3 mg/kg i.v. decreases systemic blood pressure by 4% and reflexly increases heart rate by 8%. Cinepazide selectively stimulates the functional activities of 5-HT neurons in the brain, which are depressed by hypoxia.
    Animal modelMale Wistar rats
    Formulation & DosageDissolved in saline; 4 mg/kg, 20 mg/kg, 100 mg/kg and 150 mg/kg; i.p. injection
    References

    Nihon Yakurigaku Zasshi. 1979 Jul;75(5):507-16; Jpn J Pharmacol. 1986 May;41(1):109-15. 


    These protocols are for reference only. InvivoChem does not independently validate these methods.

    评论

      Home Prev Next Last page / pices

      发评论

      ×
      Your information is safe with us. * Required Fields.
      Products are for research use only;  We do not sell to patients
      Tel: 1-708-310-1919
      Fax: 1-708-557-7486
      Subscribe to our E-newsletter
      • Name*
      • *
      • E-mail*
      • *
      • instructions:
      • *
      Copyright 2020 InvivoChem LLC | All Rights Reserved
      prompt
      Do you confirm the receipt?