Size | Price | Stock | Qty |
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5mg |
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10mg |
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50mg |
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100mg |
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Other Sizes |
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ln Vitro |
At 70 μg/mL and an IC50 of 1.4 μM, catechin ((+)-Catechin) demonstrates >95% inhibitory action against oxidative synthase-1 (COX-1) [1]. Following a 24-hour catechin treatment, a color decrease was noted. At the measured catechin concentration of 160 μg/mL, the cell death rate was 54.76%, and the catechin's IC50 value was 127.62 μg/mL. mL. When catechin was applied to MCF-7 cells, the maximum sterilizing rate was attained. After being treated with 150 μg/mL and 300 μg/mL catechin for 24 hours, the sterilization rates were 40.7% and 41.16%, respectively, in comparison to control cells. In MCF-7 cells, the expression levels of Caspase-3, -8, -9, and p53 increased by 5.81 times, 1.42 times, 3.29 times, and 2.68 times, respectively, following a 24-hour treatment with 150 μg/mL catechin. intervals[2].
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ln Vivo |
In choice trials, animals treated with catechin ((+)-catechin) at the lowest tested dose of 50 mg/kg comparatively spent more time investigating novel items; however, this difference was not statistically significant. In a dosage-dependent way, catechin guards against time-induced episodic memory losses; in mice, 200 mg/kg is the most beneficial dose. The administration of catechin therapy inhibited the rise in MPO levels (21.98±9.44 and 36.76±4.39% in the frontal cortex and hippocampal regions, respectively), as compared to the DOX alone treatment group [3].
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References |
[1]. Waffo-Téguo P, et al. Potential cancer-chemopreventive activities of wine stilbenoids and flavans extracted from grape (Vitis vinifera) cell cultures. Nutr Cancer. 2001;40(2):173-9.
[2]. Cheruku SP, et al. Catechin ameliorates doxorubicin-induced neuronal cytotoxicity in in vitro and episodic memory deficit in in vivo in Wistar rats. Cytotechnology. 2018 Feb;70(1):245-259. [3]. Alshatwi AA. Catechin hydrate suppresses MCF-7 proliferation through TP53/Caspase-mediated apoptosis. J Exp Clin Cancer Res. 2010 Dec 17;29:167 |
Molecular Formula |
C15H14O6
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Molecular Weight |
290.271
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Exact Mass |
290.079
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CAS # |
154-23-4
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Related CAS # |
(±)-Catechin;7295-85-4;(+)-Catechin hydrate;225937-10-0;(-)-Catechin;18829-70-4;Catechin-13C3
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SMILES |
O1C2=C([H])C(=C([H])C(=C2C([H])([H])[C@]([H])([C@@]1([H])C1C([H])=C([H])C(=C(C=1[H])O[H])O[H])O[H])O[H])O[H]
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Synonyms |
KB-53; KB 53; Cianidanol
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture and light. |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
DMSO : ~100 mg/mL (~344.51 mM)
H2O : ~12.5 mg/mL (~43.06 mM) |
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Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (8.61 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (8.61 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C,1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (8.61 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 3.4451 mL | 17.2253 mL | 34.4507 mL | |
5 mM | 0.6890 mL | 3.4451 mL | 6.8901 mL | |
10 mM | 0.3445 mL | 1.7225 mL | 3.4451 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.