| Size | Price | |
|---|---|---|
| Other Sizes |
| ln Vitro |
(-)-Carvone inactivates eel AChE with a Ki value of 2.19 mM (3.04 mM; 30 minutes)[1].
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|---|---|
| ln Vivo |
(-)-Carvone (5% absolute ethanol v/v, 20 μL; applied to the ventral surface of the thorax) inhibits AChE in vitro, including cholinesterase from Madagascar in the cockroach head and thorax, and cholinesterase from horse serum. 1]. (-)-Carvone (0.05%–0.1% w/v; oral administration; 7 d) inhibits E. insulana larvae growth and decreases larval weight [2].
|
| Animal Protocol |
Animal/Disease Models: Female cockroach (Gromphadorhina portentosa) (6.4 g-6.8 g) [1]
Doses: 5% absolute ethanol v/v, 20 μL Route of Administration: Apply to the ventral surface of the thorax; at different time intervals (0 , 2, 4, 5, 20, 24 and 26 hrs (hrs (hours))) for decapitation and rough processing. Experimental Results: Inhibition of AChE activity in head and chest extracts. |
| Toxicity/Toxicokinetics |
439570 Oral LD50 in rats: 1640 mg/kg, Food and Cosmetic Toxicology, 11(1057), 1973. 439570 Intravenous LD50 in mice: 56 mg/kg, U.S. Army Armaments Research and Development Command Chemical Systems Laboratory, NIOSH Exchange Chemicals, NX#02834. 439570 Oral LD50 in guinea pigs: 766 mg/kg, Food and Cosmetic Toxicology, 11(1057), 1973.
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| References |
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| Additional Infomation |
(-)-Carvone is a carvone with an (R) configuration, which is the enantiomer of (+)-carvone.
Carvone has been reported to be found in chamomile (Matricaria discoidea), camphor thyme (Thymus camphoratus), and other organisms with relevant data. See also: spearmint oil (partial composition); myrrh (partial composition); carvone, (+/-)- (note moved to). The effects of (-)-carvone on the larval development of island bug (Earias insulana Boisd.) were investigated. Different concentrations of carvone were added to a semi-synthetic diet, and larval growth, pupation rate, and mortality were recorded. Carvone showed high killing efficacy against 7-day-old larvae across all concentration ranges from 0.1% to 1%. [1] |
| Molecular Formula |
C10H14O
|
|---|---|
| Molecular Weight |
150.22
|
| Exact Mass |
150.104
|
| CAS # |
6485-40-1
|
| Related CAS # |
Carvone;99-49-0;(S)-(+)-Carvone;2244-16-8
|
| PubChem CID |
439570
|
| Appearance |
Colorless to light yellow liquid
|
| Density |
0.958
|
| Boiling Point |
227-230 ºC
|
| Melting Point |
25.2ºC
|
| Flash Point |
88 ºC
|
| Vapour Pressure |
0.1±0.5 mmHg at 25°C
|
| Index of Refraction |
1.481
|
| Source |
Originated from plants: Compositae Gymnaster koraiensis
Originated from plants: Umbelliferae |
| LogP |
2.27
|
| Hydrogen Bond Donor Count |
0
|
| Hydrogen Bond Acceptor Count |
1
|
| Rotatable Bond Count |
1
|
| Heavy Atom Count |
11
|
| Complexity |
223
|
| Defined Atom Stereocenter Count |
1
|
| SMILES |
O=C1C(C([H])([H])[H])=C([H])C([H])([H])[C@@]([H])(C(=C([H])[H])C([H])([H])[H])C1([H])[H]
|
| InChi Key |
ULDHMXUKGWMISQ-SECBINFHSA-N
|
| InChi Code |
InChI=1S/C10H14O/c1-7(2)9-5-4-8(3)10(11)6-9/h4,9H,1,5-6H2,2-3H3/t9-/m1/s1
|
| Chemical Name |
(5R)-2-methyl-5-prop-1-en-2-ylcyclohex-2-en-1-one
|
| Synonyms |
AI3-36200; EINECS 229-352-5; (-)-Carvone; 6485-40-1; l-Carvone; (R)-(-)-Carvone; L(-)-Carvone; (R)-2-Methyl-5-(prop-1-en-2-yl)cyclohex-2-enone; (R)-Carvone; Levo-carvone; (-)-Carvone; L(-)-Carvone; l-Carvone
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| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO : ~100 mg/mL (~665.69 mM)
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (16.64 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween-80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), Clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of DMSO stock solution (25.0 mg/mL) to 400 μL of PEG300 and mix well; then add 50 μL of Tween-80 and mix well; finally add 450 μL of physiological saline and adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (16.64 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), Clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of DMSO stock solution (25.0 mg/mL) to 900 μL of corn oil and mix well. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 6.6569 mL | 33.2845 mL | 66.5690 mL | |
| 5 mM | 1.3314 mL | 6.6569 mL | 13.3138 mL | |
| 10 mM | 0.6657 mL | 3.3285 mL | 6.6569 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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