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    Carteolol HCl (OPC-1085 HCl)
    Carteolol HCl (OPC-1085 HCl)

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1104
    CAS #: 51781-21-6Purity ≥98%

    Description: Carteolol HCl (OPC1085; Arteoptic; Cartrol; Mikelan; Abbott-43326), the hydrochloride salt of Carteolol, is a potent and non-selective β-adrenoceptor antagonist that was approved for the treatment of glaucoma. Carteolol was found to be a nonconventional partial agonist, which causes agonistic effects via interaction with the low-affinity propranolol-resistant site of β1-adrenoceptors and antagonistic actions by the high-affinity site of the same receptors.

    References: J Pharmacol Exp Ther. 2005 Dec;315(3):1386-95; Int Ophthalmol. 1989 Jan;13(1-2):85-9.

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    Molecular Weight (MW)328.83 
    FormulaC16H25ClN2O3 
    CAS No.51781-21-6 
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 65 mg/mL (197.7 mM) 
    Water: <1 mg/mL
    Ethanol: 65 mg/mL (197.7 mM) 
    Other info

    Chemical Name: 5-[3-(tert-butylamino)-2-hydroxypropoxy]-3,4-dihydro-1H-quinolin-2-one;hydrochloride

    InChi Key: FYBXRCFPOTXTJF-UHFFFAOYSA-N

    InChi Code: InChI=1S/C16H24N2O3.ClH/c1-16(2,3)17-9-11(19)10-21-14-6-4-5-13-12(14)7-8-15(20)18-13;/h4-6,11,17,19H,7-10H2,1-3H3,(H,18,20);1H

    SMILES Code: CC(C)(C)NCC(COC1=CC=CC2=C1CCC(=O)N2)O.Cl

    SynonymsOPC 1085; Carteolol Hydrochloride ; Carteolol HCl; OPC-1085; OPC1085; Arteoptic; Cartrol; Mikelan; Abbott-43326; Hydrochloride, Carteolol; Monohydrochloride, Carteolol; 


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    In Vitro

    In vitro activity: Previous findings demonstrate that carteolol, unlike xamoterol, is a nonconventional partial agonist, which causes agonistic effects via interaction with the low-affinity propranolol-resistant site of β1-adrenoceptors and antagonistic actions by the high-affinity site of the same receptors.

    In VivoBoth 8-OH carteolol and carteolol suppressed the water-load induced intraocular pressure (IOP) rise in rabbits. 8-OH carteolol was more effective in suppressing water-load induced IOP rise in rabbits compared with carteolol on equimolar basis. Both 8-OH carteololand carteolol caused a significant decrease in IOP in monkeys. 8-OH carteolol was estimated to be more potent than carteolol in lowering IOP on equimolar basis in monkeys. 
    Animal modelMonkeys
    Formulation & DosageN/A
    References

    J Pharmacol Exp Ther. 2005 Dec;315(3):1386-95; Int Ophthalmol. 1989 Jan;13(1-2):85-9. 


    These protocols are for reference only. InvivoChem does not independently validate these methods.

     

    Carteolol HCl

    Mean concentration-effect curves for the chronotropic and inotropic effects of carteolol and xamoterol in guinea pig spontaneously beating atria. J Pharmacol Exp Ther. 2005 Dec;315(3):1386-95. 
     

    Carteolol HCl

    Mean concentration-effect curves for the inotropic effect of carteolol and xamoterol on guinea pig left atria electrically driven at 2 Hz.  J Pharmacol Exp Ther. 2005 Dec;315(3):1386-95. 
     

    Carteolol HCl

    Concentration-effect curves for the chronotropic effects of carteolol, xamoterol, and isoprenaline in the absence and presence of propranolol. J Pharmacol Exp Ther. 2005 Dec;315(3):1386-95. 


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