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    Capmatinib HCl hydrate (INCB-28060; INC280)
    Capmatinib HCl hydrate (INCB-28060; INC280)

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V2201
    CAS #: 1865733-40-9Purity ≥98%

    Description: Capmatinib HCl hydrate (INCB-28060; INC280) is a novel, potent, orally bioavailable, ATP-competitive inhibitor of c-MET with IC50 of 0.13 nM in a cell-free assay, inactive against RONβ, as well as EGFR and HER-3. c-Met inhibitor INC280 selectively binds to c-Met, thereby inhibiting c-Met phosphorylation and disrupting c-Met signal transduction pathways. This may induce cell death in tumor cells overexpressing c-Met protein or expressing constitutively activated c-Met protein. 

    References: Clin Cancer Res. 2011 Nov 15;17(22):7127-38.

    Related CAS #: 1029712-80-8 (free base)  1197376-85-4 (2HCl)  1029714-89-3 (XHCl); 1865733-40-9 (HCl hydrate)

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    Molecular  Formula: C23H21Cl2FN6O2
    Molecular Weight: 503.3594
    Elemental Analysis: C, 54.88; H, 4.21; Cl, 14.09; F, 3.77; N, 16.70; O, 6.36

    Related CAS #: 1029712-80-8 (free base)   1865733-40-9 (HCl hydrate)   1029714-89-3 (xHCl)   1197376-85-4 (2HCl)   1197376-90-1 (besylate)   1450883-33-6 (fumarate)    

    Synonym: Capmatinib hydrochloride; NVP-INC 280AAA; INC280; INC-280; INC 280; INCB028060; INCB-028060; INCB 028060; INCB28060; INCB-28060; INCB 28060; Capmatinib.

    Chemical Name: 2-Fluoro-N-methyl-4-[7-[(quinolin-6-yl)methyl]imidazo[1,2-b]-[1,2,4]triazin-2-yl]benzamide dihydrochloride hydrate

    InChi Key: COWBUPJEEDYWKD-UHFFFAOYSA-N

    InChi Code: InChI=1S/C23H17FN6O.2ClH.H2O/c1-25-22(31)18-6-5-16(11-19(18)24)21-13-28-23-27-12-17(30(23)29-21)10-14-4-7-20-15(9-14)3-2-8-26-20;;;/h2-9,11-13H,10H2,1H3,(H,25,31);2*1H;1H2

    SMILES Code: O=C(NC)C1=CC=C(C2=NN3C(N=C2)=NC=C3CC4=CC=C5N=CC=CC5=C4)C=C1F.[H]Cl.[H]Cl.[H]O[H]


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