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    Calcium D-Panthotenate (Calcium pantothenate)
    Calcium D-Panthotenate (Calcium pantothenate)

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1880
    CAS #: 137-08-6 Purity ≥98%

    Description: Calcium D-Panthotenate (also known as vitamin B5 Calcium or D-Pantothenic Acid Calcium; D-Pantothenic acid hemicalcium salt) is a water-soluble vitamin and an essential nutrient for many animals and is a precursor for coenzyme A biosynthesis. Pantothenic acid participates in a number of intermediary metabolic reactions as a component of coenzyme A (CoA). It has been reported that pantothenic acid exhibits radioprotective and antioxidative effects and pantothenic acid has the potential to protect against cell damage produced by reactive oxygen species.

    References: FEBS Lett. 2004 Jul 2;569(1-3):169-72; Biofactors. 2003;17(1-4):61-73.

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    Molecular Weight (MW)476.53 
    FormulaC18H32CaN2O10 
    CAS No.137-08-6 
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 44 mg/mL (92.3 mM)
    Water: 44 mg/mL (92.3 mM)
    Ethanol: <1 mg/mL
    SMILESO[[email protected]@H](C(NCCC([O-])=O)=O)C(C)(C)CO.[0.5Ca2+]
    SynonymsD-Pantothenic Acid Calcium; Calcium D-pantothenate; Vitamin B5 calcium salt; Calcium pantothenate


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    In Vitro

    In vitro activity: Pantothenic acid increases mainly the content of free glutathione, with little effect on protein-boundglutathione in human lymphoblastoic (Jurkat) cells. Pantothenic acid also increases cell respiration with pyruvate as the exogenous substrate. Pantothenic acid belongs to vitamin B group and is the building stone of coenzyme A. Pantothenic acid can be therefore infer that its beneficial effect in various kinds of cell damage by ROS is related to the increased content or stimulated biosynthesis of this coenzyme. Pantothenic acid increases the glutathione content by more than 50% and increases the GSH/GSSG ratio by approximately the same factor. Pantothenic acid and N-acetylcysteine alleviates the ultraviolet-induced decrease of glutathione content, diminished lipid peroxidation, and partly protects the cells against apoptosisproduced by ultraviolet irradiation.


    Cell Assay: Pantothenic acid (1 mM) increased biosynthesis of glutathione by boosting cell energetic in Jurkat cells. In addition, pantothenic acid (1 mM) protected against oxidative damage and apoptosis in Ehrlich ascites tumour cells.

    In VivoPantothenic acid-treated rats exhibited higher basal levels of corticosterone and progesterone than control rats in Adrenal cells. The response of ACTH and/or PRL on corticosterone and progesterone release is higher in the pantothenic acid-treated rats than in the control rats. Pantothenic acid supplementation stimulates the ability of adrenal cells in male rats to secrete corticosterone and progesterone. Pantothenic acid supplementation induces adrenalhyperresponsiveness to ACTH stimulation, and PRL further stimulated adrenal sensitivity to ACTH. Pantothenic acid prior to valproic acid (VPA) significantly protects against VPA-induced neural tube defects (NTDs) in CD-1mice. Pantothenic acid prevents VPA-induced alterations in NF-kappaB, Pim-1, and c-Myb in CD-1 mice. 
    Animal modelPantothenic acid (200 mg/kg, intraperitoneal injections) completely blocked valproic acid-induced neural tube defects and the decreases in c-Myb and Pim-1 protein expression in CD-1 mice. Moreover, Calcium D-pantothenate (3.39-10.54 mg/kg, diets) increased the intestinal enzymes activities and docosahexaenoic acid (DHA) levels.  
    Formulation & Dosage3.39-10.54 mg/kg, diets
    ReferencesFEBS Lett. 2004 Jul 2;569(1-3):169-72; Biofactors. 2003;17(1-4):61-73; Toxicol Appl Pharmacol. 2006 Mar 1;211(2):124-32. 


    These protocols are for reference only. InvivoChem does not independently validate these methods.

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