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    Buspirone HCl (MJ90221) HCl
    Buspirone HCl (MJ90221) HCl

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V0971
    CAS #: 33386-08-2Purity ≥98%

    Description: Buspirone HCl (MJ90221, MJ-90221, Buspar, MJ-9022-1, MJ9022 1, MJ9022-1), the hydrochloride salt of  Buspirone which is an azapirone anolog, is a potent serotonergic 5HT1A receptor agonist with anti-psychotic effects. Buspirone has been approved for use as an anxiolytic psychotropic drug. It is primarily used to treat generalized anxiety disorder (GAD). Unlike most drugs predominantly used to treat anxiety, buspirone's pharmacology is not related to benzodiazepines or barbiturates, and so does not carry the risk of physical dependence and withdrawal symptoms. 

    References: Eur J Pharmacol. 1986 Sep 23;129(1-2):123-30; Am J Med. 1986 Mar 31;80(3B):41-51.

    Related CAS #: 36505-84-7 (free); 33386-08-2 (HCl)

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    Molecular Weight (MW)421.96
    FormulaC21H31N5O2.HCl
    CAS No.33386-08-2
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 84 mg/mL (199.1 mM)
    Water: 84 mg/mL (199.1 mM)
    Ethanol: 36 mg/mL (85.3 mM)
    Solubility (In vivo)15% Captisol, pH 9: 10 mg/mL  
    SynonymsBuspirone, MJ 9022 1, Buspar, MJ-9022-1, MJ90221, MJ9022 1, MJ9022-1
    SMILES CodeO=C(N(CCCCN1CCN(C2=NC=CC=N2)CC1)C(C3)=O)CC43CCCC4.Cl


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    In Vitro

    In vitro activity: Buspirone, a clinically effective non-benzodiazepine anxiolytic drug, causes inhibition of firing of these neurons when given by intravenous (ED50 = 0.011 mg/kg, i.v.), intraperitoneal (ED50 = 0.088 mg/kg, i.p.), and intragastric (effective dose = 1.0-20.0 mg/kg, i.g.) injection. Buspirone also inhibits these cells when it is administered to the outside of recorded neurons by microiontophoresis. Buspirone is eliminated primarily by oxidative metabolism, which produces several hydroxylated metabolites, including 5-hydroxy-buspirone and 1-pyrimidinylpiperazine.

    In VivoBuspirone (3 mg/rat, i.p.) dose dependently and completely inhibits shock-induced ultrasonic vocalization after systemic injection and after microinjection into the dorsal raphe nucleus of rats, a brain region rich in somatodendritic 5-HT1A receptors. Buspirone (20 mg/kg) decreases immobility in the rat forced swim test. Buspirone is a serotonergic (5HT(1A) receptor agonist) anxiolytic drug with some D(2) dopaminergic effect in a zebrafish model of anxiety. Buspirone dose-dependently reduces LID and improved l-DOPA-related motor performance due to action at the 5-HT(1A) receptor in l-DOPA-primed rats. Buspirone delayes LID development while improving l-DOPA's anti-parkinsonian efficacy indicating the potential long-term benefits of 5-HT(1A) agonists for reduction of l-DOPA-related side effects in l-DOPA-naive rats.
    Animal modelRats
    Formulation & Dosage3, 20 mg/rat, i.p.
    References

    Eur J Pharmacol. 1986 Sep 23;129(1-2):123-30; Am J Med. 1986 Mar 31;80(3B):41-51; Eur J Pharmacol. 1993 Nov 16;249(3):341-51.


    These protocols are for reference only. InvivoChem does not independently validate these methods.

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