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      Budesonide
      Budesonide

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      This product is for research use only, not for human use. We do not sell to patients.
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      InvivoChem Cat #: V1704
      CAS #: 51333-22-3Purity ≥98%

      Description: Budesonide (Rhinocort; Budicort; Entocort; Rhinosol; Pulmicort; Symbicort; Noex Entocort EC) is a synthetic glucocorticoid steroid approved for use in the treatment of inflammatory conditions such as asthma, non-infectious rhinitis, and nasal polyposis. In addition, it is used for treating Crohn's disease (inflammatory bowel disease).  

      References: J Immunol. 1999 Nov 15;163(10):5624-32; Vascul Pharmacol. 2005 Aug;43(2):101-11.

      Related CAS: 51372-29-3  [(22R)-Budesonide]

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      Molecular Weight (MW)430.53
      FormulaC25H34O6
      CAS No.51333-22-3
      Storage-20℃ for 3 years in powder form
      -80℃ for 2 years in solvent
      Solubility (In vitro)DMSO: 86 mg/mL (199.7 mM)
      Water:<1 mg/mL
      Ethanol: 19 mg/mL (44.1 mM)
      Other info

      Chemical Name: (6aR,6bS,7S,8aS,8bS,11aR,12aS,12bS)-7-hydroxy-8b-(2-hydroxyacetyl)-6a,8a-dimethyl-10-propyl-6a,6b,7,8,8a,8b,11a,12,12a,12b-decahydro-1H-naphtho[2',1':4,5] indeno[1,2-d][1,3]dioxol-4(2H)-one

      InChi Key: VOVIALXJUBGFJZ-KWVAZRHASA-N

      InChi Code: InChI=1S/C25H34O6/c1-4-5-21-30-20-11-17-16-7-6-14-10-15(27)8-9-23(14,2)22(16)18(28)12-24(17,3)25(20,31-21)19(29)13-26/h8-10,16-18,20-22,26,28H,4-7,11-13H2,1-3H3/t16-,17-,18-,20+,21?,22+,23-,24-,25+/m0/s1

      SMILES Code: O=C(C=C[[email protected]@]12C)C=C1CC[[email protected]@]([[email protected]]2([H])[[email protected]@H](O)C[[email protected]@]34C)([H])[[email protected]]3([H])C[[email protected]]5([H])[[email protected]@]4(C(CO)=O)OC(CCC)O5

      Synonyms

      Rhinocort; Budicort; Entocort; Rhinosol; Pulmicort; Symbicort; Noex Entocort EC


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      In Vitro

      In vitro activity: Budesonide effectively inhibits production of eotaxin and RANTES protein although Budesonide inhibits the expression of chemokine mRNA to a variable extent in the human bronchial epithelial cell line BEAS-2B and in primary human bronchial epithelial cells. Budesonide inhibits both RANTES- and eotaxin promoter-driven reporter gene activity in the human bronchial epithelial cell line BEAS-2B and in primary human bronchial epithelial cells. Budesonide also selectively accelerates the decay of eotaxin and MCP-4 mRNA in the human bronchial epithelial cell line BEAS-2B and in primary human bronchial epithelial cells. Budesonide time- and protein synthesis-dependently reduces VEGF secretion and VEGF mRNA expression in both cell types and these effects are inhibited by mifepristone (RU 486), a glucocorticoid receptor antagonist, suggesting that Budesonide reduces VEGF secretion and expression through its glucocorticoid receptor-mediated action. Budesonide causes a dose-dependent, almost total, inhibition of swine dust-induced IL-6 and IL-8 release from epithelial cells and LPS-induced IL-6 and TNF-alpha from alveolar macrophages.

      In VivoBudesonide totally prevents the increased production of TNF-alpha, interleukin (IL)-1beta, IL-6, and monocyte chemoattractive protein (MCP)-1 after LPS challenge at both low (2.5 mg/mL/kg) and high (50 mg/mL/kg) concentrations in rats. Budesonide exerts its effects of chemoprevention through growth arrest via Mad2/3 and through apoptosis via Bim/Blk and, by inference, caspase-8/9 in A/J mice. 
      Animal modelMice
      Formulation & Dosage2.5, 50 mg/mL/kg
      References

      J Immunol. 1999 Nov 15;163(10):5624-32; Vascul Pharmacol. 2005 Aug;43(2):101-11.

      These protocols are for reference only. InvivoChem does not independently validate these methods.

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