Blonanserin (AD-5423)

Alias: AD 5423; AD-5423; AD5423
Cat No.:V1021 Purity: ≥98%
Blonanserin (formerly AD 5423; AD-5423; AD5423)is anatypical antipsychotic agent acting as arelatively selective serotonin (5-HT) 2A and dopamine D2 antagonist with the potential to be used for the treatment of schizophrenia.
Blonanserin (AD-5423) Chemical Structure CAS No.: 132810-10-7
Product category: 5-HT Receptor
This product is for research use only, not for human use. We do not sell to patients.
Size Price Stock Qty
10mg
25mg
50mg
100mg
250mg
500mg
1g
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Other Forms of Blonanserin (AD-5423):

  • Blonanserin-d5 (AD-5423-d5)
  • Blonanserin HCl
Official Supplier of:
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Purity & Quality Control Documentation

Purity: ≥98%

Product Description

Blonanserin (formerly AD 5423; AD-5423; AD5423) is an atypical antipsychotic agent acting as a relatively selective serotonin (5-HT)2A and dopamine D2 antagonist with the potential to be used for the treatment of schizophrenia. Blonanserin has a better tolerability profile than many other antipsychotics because it doesn't cause side effects like hypotension, excessive sedation, or extrapyramidal symptoms. Blonanserin, like many other 2nd-generation (atypical) antipsychotics, is much more effective than haloperidol or other 1st-generation (typical) antipsychotics at treating the negative symptoms of schizophrenia.

Biological Activity I Assay Protocols (From Reference)
Targets
D2 Receptor ( Ki = 0.142 nM ); D3 Receptor ( Ki = 0.494 nM ); D4 Receptor ( Ki = 150 nM ); D1 Receptor ( Ki = 1070 nM ); 5-HT2A Receptor ( Ki = 0.812 nM );
5-HT2C Receptor ( Ki = 26.4 nM ); 5-HT6 Receptor ( Ki = 11.7 nM ); α1-adrenergic receptor ( Ki = 26.7 ); α2-adrenergic receptor ( Ki = 530 )
ln Vitro

In vitro activity: Blonanserin exhibits considerable affinity for the D3 receptor (Ki=0.494 nM) and blocks some α1-adrenergic receptors (Ki=26.7 nM). Blonanserin has a low affinity for the sigma receptor (IC50=286 nM), but it is not very effective at many other sites, such as the monoamine transporters, 5-HT1A, 5-HT3, D1, α2-adrenergic, β-adrenergic, H1, and mACh receptors[1].

ln Vivo
Blonanserin (oral gavage; 1 mg/kg; 14 days) inhibits the decline in Ser897-phosphorylation levels and significantly improves the social deficit seen in mice given PCP; however, blonanserin treatment has no effect on the social behaviors of mice given saline[2].
Animal Protocol
Mice received saline or phencyclidine once a day for 14 consecutive days
1 mg/kg
Oral gavage; 1 mg/kg; 14 days
References

[1]. Blonanserin.

[2]. Blonanserin ameliorates social deficit through dopamine-D 3 receptor antagonism in mice administered phencyclidine as an animal model of schizophrenia. Neurochem Int. 2019 Sep;128:127-134.

These protocols are for reference only. InvivoChem does not independently validate these methods.
Physicochemical Properties
Molecular Formula
C23H30FN3
Molecular Weight
367.5
Exact Mass
367.24
Elemental Analysis
C, 75.17; H, 8.23; F, 5.17; N, 11.43
CAS #
132810-10-7
Appearance
Solid powder
SMILES
CCN1CCN(CC1)C2=NC3=C(CCCCCC3)C(=C2)C4=CC=C(C=C4)F
InChi Key
XVGOZDAJGBALKS-UHFFFAOYSA-N
InChi Code
InChI=1S/C23H30FN3/c1-2-26-13-15-27(16-14-26)23-17-21(18-9-11-19(24)12-10-18)20-7-5-3-4-6-8-22(20)25-23/h9-12,17H,2-8,13-16H2,1H3
Chemical Name
2-(4-ethylpiperazin-1-yl)-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine
Synonyms
AD 5423; AD-5423; AD5423
HS Tariff Code
2934.99.9001
Storage

Powder      -20°C    3 years

                     4°C     2 years

In solvent   -80°C    6 months

                  -20°C    1 month

Shipping Condition
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
Solubility Data
Solubility (In Vitro)
DMSO: ~5 mg/mL (~13.6 mM)
Water: <1 mg/mL
Ethanol: <1 mg/mL
Preparing Stock Solutions 1 mg 5 mg 10 mg
1 mM 2.7211 mL 13.6054 mL 27.2109 mL
5 mM 0.5442 mL 2.7211 mL 5.4422 mL
10 mM 0.2721 mL 1.3605 mL 2.7211 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.

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Working concentration mg/mL;

Method for preparing DMSO stock solution mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation:Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
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Clinical Trial Information
NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT01796730 Completed Drug: bambuterol
Drug: Placebo
COPD The First Affiliated Hospital of
Guangzhou Medical University
February 2013 Phase 4
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