| Size | Price | Stock | Qty |
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| 1mg |
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| 5mg |
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| Other Sizes |
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Purity: ≥98%
Bifluranol (formerly also known as BX-341; traded name Prostarex), a novel fluorinated bibenzyl anti-androgen, is a potent and synthetic nonsteroidal estrogen of the stilbestrol calss related to diethylstilbestrol that has been used as an antiandrogen in the United Kingdom in the treatment of benign prostatic hyperplasia. It exerts functional antiandrogen effects by binding to and activating the estrogen receptor in the pituitary gland, consequently suppressing the secretion of luteinizing hormone (and hence acting as an antigonadotropin) and thereby reducing gonadal androgen production and systemic androgen levels.
| ln Vivo |
Diflunol's distribution, absorption, and excretion have all been studied in mice, rats, ferrets, and dogs. Although diflunol is easily absorbed when taken orally, its concentration in blood is lower because of hepatic absorption and bile excretion. Following an intravenous injection of [3H]difluorol in rats (200 μg/kg) and ferrets (60 μg/kg), there was a rapid decrease in 3H blood concentrations within the first two to three hours. In female mice, this decrease was more rapid (18 minutes). compared to males (rats 1.0 hours, ferrets 1.4 hours) (rats, 30 minutes). Following this, the concentration drops below 15 ng bisfluranol equivalent mL-1 (rat) or 1 ng bisfluranol equivalent mL-1 (ferret) after 96 hours, with the rate of decline being much slower (40 hours for rats and 20 hours for ferrets) [1].
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| References |
[1]. Pope DJ, et al. Bifluranol, a novel fluorinated bibenzyl anti-androgen, its chemistry and disposition in different animal species. J Pharm Pharmacol. 1981 May;33(5):297-301
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| Molecular Formula |
C17H18O2F2
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|---|---|
| Molecular Weight |
292.32042
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| CAS # |
34633-34-6
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| SMILES |
C[C@H](C1=CC=C(O)C(F)=C1)[C@H](C2=CC=C(O)C(F)=C2)CC
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| InChi Key |
RDVXUHOSYIBGBT-ZWNOBZJWSA-N
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| InChi Code |
InChI=1S/C17H18F2O2/c1-3-13(12-5-7-17(21)15(19)9-12)10(2)11-4-6-16(20)14(18)8-11/h4-10,13,20-21H,3H2,1-2H3/t10-,13-/m1/s1
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| Chemical Name |
Phenol, 4,4'-(1-ethyl-2-methyl-1,2-ethanediyl)bis(2-fluoro-, (R*,S*)-
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| Synonyms |
BX-341; BX-341; BX-341; traded name Prostarex
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~100 mg/mL (~342.09 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (8.55 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (8.55 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.4209 mL | 17.1045 mL | 34.2091 mL | |
| 5 mM | 0.6842 mL | 3.4209 mL | 6.8418 mL | |
| 10 mM | 0.3421 mL | 1.7105 mL | 3.4209 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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