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    Betamethasone Valerate (BV; BET)
    Betamethasone Valerate (BV; BET)

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1711
    CAS #: 2152-44-5 Purity ≥98%

    Description: Betamethasone Valerate (also known as BV or BET, betamethasone 17-valerate) is a moderately potent glucocorticoid steroid with anti-inflammatory and immunosuppressive activities. Betamethasone valerate is a commonly used anti-inflammatory corticosteroid, used to manufacture dermatological drug products for topical applications. Its IC50 in normal rats is 3.4±0.5 nM. Betamethasone Valerate can reduce glucose-6-phosphate dehydrogenase (G-6-PDH) activity in vitro. 

    References: Spectrochim Acta A Mol Biomol Spectrosc. 2015 Apr 5;140:294-304; Br Med J. 1971 Jul 10;3(5766):84-6; J Pharm Biomed Anal. 2011 Jan 5;54(1):242-7. 

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    Molecular Weight (MW)476.58 
    FormulaC27H37FO6 
    CAS No.2152-44-5  
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 95 mg/mL (199.3 mM)
    Water: <1 mg/mL
    Ethanol: 58 mg/mL (121.7 mM) 
    Other info

    Chemical Name: (8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro-11-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl pentanoate

    InChi Key: SNHRLVCMMWUAJD-SUYDQAKGSA-N

    InChi Code: InChI=1S/C27H37FO6/c1-5-6-7-23(33)34-27(22(32)15-29)16(2)12-20-19-9-8-17-13-18(30)10-11-24(17,3)26(19,28)21(31)14-25(20,27)4/h10-11,13,16,19-21,29,31H,5-9,12,14-15H2,1-4H3/t16-,19-,20-,21-,24-,25-,26-,27-/m0/s1

    SMILES Code: O=C1C=C[[email protected]@]2([[email protected]]3([[email protected]](C[[email protected]@]4([[email protected]](OC(CCCC)=O)([[email protected]](C[[email protected]]4([[email protected]@]3(CCC2=C1)[H])[H])C)C(CO)=O)C)O)F)C

    Synonyms

    BV; BET; betamethasone 17-valerate; Betamethasone Valerate; Betoid; Valison; 9α-Fluo; Valisone; Bedermin; Betneval; Beta-Val; Bextasol; Dermosol; Stanoval


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    In Vitro

    In vitro activity: The presence of BV at a concentration of 4.6 mM/l provoked a still further diminuition of the G-6-PDH-activity of human skin homogenates that followed the incubation for 120 min at 37°C in media containing 5% dimethylformamide and in which the concentration of G-6-PDH changed from about 55 mU/ml to 9 mU/ml.

    In VivoCompared with sodium cromoglycate (SCG, 80mg daily), treatment of betamethasone valerate (BV, 800μg daily) for 4 weeks made children requiring bronchodilators for perennial asthma significantly require less bronchodilator drugs, and have fewer symptoms and higher daily peak expiratory flow rates. Compared with coal tar (10% LCD) cream, after a 2 week wash-out period, treatment with betamethasone valerate cream (0.1%) twice daily for 6 weeks made patients with stable, mild-moderate plaque psoriasis get more mean reduction of PASI score from baseline. The final effect of betamethasone valerate was significantly greater clearance and improvement . 
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    References

    Spectrochim Acta A Mol Biomol Spectrosc. 2015 Apr 5;140:294-304; Br Med J. 1971 Jul 10;3(5766):84-6; J Pharm Biomed Anal. 2011 Jan 5;54(1):242-7.  


    These protocols are for reference only. InvivoChem does not independently validate these methods.

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