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| 500mg |
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Purity: ≥98%
Berberine HCl (Natural Yellow 18 chloride), an isoqinoline alkaloid extracted from the Chinese herbal medicine Huanglian, is a quaternary ammonium salt from the group of isoquinoline alkaloids with varoius biological activities. It has been reported that berberine inhibits the enzyme Cox-2 (cyclooxygenase-2), which is highly expressed in colon cancer cells, thereby having chemopreventive effects against the formation of colon tumors. Moreover, it inhibits c-Jun (Activator Protein 1), a transcription factor essential to the development of cancer and inflammation.
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| ln Vivo |
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| References |
| Molecular Formula |
C20H18CLNO4
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| Molecular Weight |
371.81
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| Exact Mass |
371.09
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| Elemental Analysis |
C, 64.61; H, 4.88; Cl, 9.53; N, 3.77; O, 17.21
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| CAS # |
633-65-8
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| Related CAS # |
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| Appearance |
Solid powder
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| SMILES |
COC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC5=C(C=C4CC3)OCO5)OC.[Cl-]
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| InChi Key |
VKJGBAJNNALVAV-UHFFFAOYSA-M
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| InChi Code |
InChI=1S/C20H18NO4.ClH/c1-22-17-4-3-12-7-16-14-9-19-18(24-11-25-19)8-13(14)5-6-21(16)10-15(12)20(17)23-2;/h3-4,7-10H,5-6,11H2,1-2H3;1H/q+1;/p-1
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| Chemical Name |
16,17-dimethoxy-5,7-dioxa-13-azoniapentacyclo[11.8.0.02,10.04,8.015,20]henicosa-1(13),2,4(8),9,14,16,18,20-octaene;chloride
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| Synonyms |
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| HS Tariff Code |
2934.99.03.00
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
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| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
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| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 1.25 mg/mL (3.36 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 12.5 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 1.25 mg/mL (3.36 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 12.5 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: 10 mg/mL (26.90 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), suspension solution; with ultrasonication. Solubility in Formulation 4: 11 mg/mL (29.59 mM) in 0.5% CMC-Na/saline water (add these co-solvents sequentially from left to right, and one by one), suspension solution; with ultrasonication. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.6895 mL | 13.4477 mL | 26.8955 mL | |
| 5 mM | 0.5379 mL | 2.6895 mL | 5.3791 mL | |
| 10 mM | 0.2690 mL | 1.3448 mL | 2.6895 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
| NCT Number | Recruitment | interventions | Conditions | Sponsor/Collaborators | Start Date | Phases |
| NCT05105321 | Not yet recruiting | Behavioral: Healthy lifestyle intervention Drug: Berberine |
Metabolic Syndrome | Tang Yida | December 2021 | Phase 4 |
| NCT03378934 | Recruiting | Drug: Berberine Drug: Aspirin |
Percutaneous Coronary Intervention Coronary Artery Disease |
Peking Union Medical College Hospital |
September 26, 2018 | Phase 4 |
| NCT05647915 | Not yet recruiting | Drug: Berberine plus lifestyle intervention Behavioral: Placebo plus lifestyle intervention |
Obesity NAFLD |
China National Center for Cardiovascular Diseases |
December 15, 2022 | Phase 4 |
| NCT03029390 | Active Recruiting |
Dietary Supplement: Berberine Drug: Metformin |
Prediabetes Impaired Fasting Glucose |
University of Guadalajara | March 2016 | Phase 4 |
| NCT05523024 | Recruiting | Dietary Supplement: Probiotic Dietary Supplement: Placebo |
Non Alcoholic Fatty Liver Obesity |
Poznan University of Medical Sciences |
August 2, 2022 | Not Applicable |
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