Beclomethasone dipropionate (Beclomethasone)

Alias:
Cat No.:V1716 Purity: ≥98%
Beclomethasone dipropionate (also called BDP;Clenil; Qvar; Beconase; alanase; Vancenase) is a topical anti-inflammatory corticosteroid approved for use in treatment of asthma and rhinitis.
Beclomethasone dipropionate (Beclomethasone) Chemical Structure CAS No.: 5534-09-8
Product category: Glucocorticoid Receptor
This product is for research use only, not for human use. We do not sell to patients.
Size Price Stock Qty
100mg
250mg
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Other Forms of Beclomethasone dipropionate (Beclomethasone):

  • Betamethasone Dipropionate
  • Beclometasone (Beclometasone)
  • Beclometasone dipropionate monohydrate
Official Supplier of:
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Purity & Quality Control Documentation

Purity: ≥98%

Product Description

Beclomethasone dipropionate (also called BDP; Clenil; Qvar; Beconase; alanase; Vancenase) is a topical anti-inflammatory corticosteroid approved for use in treatment of asthma and rhinitis. In addition, Beclomethasone dipropionate has been reported to be previously developed as aqueous nasal formulations for the treatment of Allergic rhinitis. Moreover, Beclomethasone dipropionate has shown the availability in dry nasal aerosol formulations as chiorofluoro carbon metered-dose inhaler nasal sprays.

Biological Activity I Assay Protocols (From Reference)
ln Vitro
In 16HBE cells, beclometasone dipropionate (1-100 nM; 20 min) decreases the amounts of NT, ROS, and iNOS produced by rhIL-17A as well as STAT-1 expression[2].
ln Vivo
Beclometasone dipropionate (150 µg/kg; nebulization; male BALB/c mice) reduces the relative eosinophil number and total cell count while relieving asthma[1].
Cell Assay
Western Blot Analysis[2]
Cell Types: 16HBE cells
Tested Concentrations: 1, 10 and 100 nM
Incubation Duration: 20 min
Experimental Results: decreased the levels of iNOS, ROS and NT generated by rhIL-17A.
Animal Protocol
Animal/Disease Models: Tenweeks old male balb/c (Bagg ALBino) mouse[2].
Doses: 5 mg/kg (100 μg/ml for 60 min).
Route of Administration: Orally at 24 h and 1 h before the LPS aerosol.
Experimental Results: Dramatically (P < 0.05) inhibited the decrease of IL-10 level in BAL fluid induced by LPS exposure. Markedly decreased the release of both MMP-2 and MMP-9.

Animal/Disease Models: Male balb/c (Bagg ALBino) mouse with asthma[1]
Doses: 150 µg/kg
Route of Administration: Nebulization
Experimental Results: diminished total cell number and relative eosinophil number in BALF .
References
[1]. Hrvacić B, et, al. Applicability of an ultrasonic nebulization system for the airways delivery of beclomethasone dipropionate in a murine model of asthma. Pharm Res. 2006 Aug;23(8):1765-75.
[2]. Montalbano AM, et, al. Beclomethasone dipropionate and formoterol reduce oxidative/nitrosative stress generated by cigarette smoke extracts and IL-17A in human bronchial epithelial cells. Eur J Pharmacol. 2013 Oct 15;718(1-3):418-27.
These protocols are for reference only. InvivoChem does not independently validate these methods.
Physicochemical Properties
Molecular Formula
C28H37CLO7
Molecular Weight
521.04
CAS #
5534-09-8
SMILES
C[C@@]12[C@](C[C@H](C)[C@]2(OC(CC)=O)C(COC(CC)=O)=O)([H])[C@]3([H])CCC4=CC(C=C[C@]4(C)[C@@]3(Cl)[C@@H](O)C1)=O
InChi Key
KUVIULQEHSCUHY-XYWKZLDCSA-N
InChi Code
InChI=1S/C28H37ClO7/c1-6-23(33)35-15-22(32)28(36-24(34)7-2)16(3)12-20-19-9-8-17-13-18(30)10-11-25(17,4)27(19,29)21(31)14-26(20,28)5/h10-11,13,16,19-21,31H,6-9,12,14-15H2,1-5H3/t16-,19-,20-,21-,25-,26-,27-,28-/m0/s1
Chemical Name
(8S,9R,10S,11S,13S,14S,16S,17R)-9-chloro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-[2-(propionyloxy)acetyl]-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl propionate
Synonyms

Beclomethasone dipropionate; Clenil; Qvar; Beconase; alanase; Vancenase; Beclometasone dipropionate

Storage

Powder      -20°C    3 years

                     4°C     2 years

In solvent   -80°C    6 months

                  -20°C    1 month

Shipping Condition
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
Solubility Data
Solubility (In Vitro)
DMSO:104 mg/mL (199.6 mM)
Water:<1 mg/mL
Ethanol:18 mg/mL (34.5 mM)
Preparing Stock Solutions 1 mg 5 mg 10 mg
1 mM 1.9192 mL 9.5962 mL 19.1924 mL
5 mM 0.3838 mL 1.9192 mL 3.8385 mL
10 mM 0.1919 mL 0.9596 mL 1.9192 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.

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