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    Beclomethasone dipropionate (Beclomethasone)
    Beclomethasone dipropionate (Beclomethasone)

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1716
    CAS #: 5534-09-8Purity ≥98%

    Description: Beclomethasone dipropionate (also called BDP; Clenil; Qvar; Beconase; alanase; Vancenase) is a topical anti-inflammatory corticosteroid approved for use in treatment of asthma and rhinitis. In addition, Beclomethasone dipropionate has been reported to be previously developed as aqueous nasal formulations for the treatment of Allergic rhinitis. Moreover, Beclomethasone dipropionate has shown the availability in dry nasal aerosol formulations as chiorofluoro carbon metered-dose inhaler nasal sprays.

    References: Clin Ther. 2012 Jun;34(6):1422-31; J Allergy Clin Immunol. 1999 Dec;104(6):1215-22.

    Related CAS: 4419-39-0 (Beclometasone)

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    Molecular Weight (MW)521.04 
    FormulaC28H37ClO7 
    CAS No.5534-09-8 
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 104 mg/mL (199.6 mM) 
    Water: <1 mg/mL
    Ethanol: 18 mg/mL (34.5 mM) 
    Other info

    Chemical Name: (8S,9R,10S,11S,13S,14S,16S,17R)-9-chloro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-[2-(propionyloxy)acetyl]-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl propionate

    InChi Key: KUVIULQEHSCUHY-XYWKZLDCSA-N

    InChi Code: InChI=1S/C28H37ClO7/c1-6-23(33)35-15-22(32)28(36-24(34)7-2)16(3)12-20-19-9-8-17-13-18(30)10-11-25(17,4)27(19,29)21(31)14-26(20,28)5/h10-11,13,16,19-21,31H,6-9,12,14-15H2,1-5H3/t16-,19-,20-,21-,25-,26-,27-,28-/m0/s1

    SMILES Code: CCC(O[[email protected]]1(C(COC(CC)=O)=O)[[email protected]@H](C)C[[email protected]@]2([H])[[email protected]]3([H])CCC4=CC(C=C[[email protected]]4(C)[[email protected]@]3(Cl)[[email protected]@H](O)C[[email protected]]12C)=O)=O

    Synonyms

    Beclomethasone dipropionate; Clenil; Qvar; Beconase; alanase; Vancenase; Beclometasone dipropionate


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    In Vitro

    In vitro activity: Beclomethasone dipropionate (BDP) is an anti-inflammatory corticosteroid available for the treatment of asthma and allergic rhinitis (AR). BDP is previously developed as aqueous nasal formulations for the treatment of AR. BDP is also available in dry nasal aerosol formulations as chlorofluoro carbon (CFC) metered-dose inhaler nasal sprays, but CFC-containing formulations have been withdrawn from the market and currently are not available.BDP hydrofluoroalkane (HFA) inhalation aerosol currently is available for patient use and indicated for the maintenance treatment of asthma as prophylactic therapy in patients 5 years of age and older.BDP HFA nasal aerosol, an intranasal aerosol formulation, has been developed recently for the treatment of AR.

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    References

    Clin Ther. 2012 Jun;34(6):1422-31; J Allergy Clin Immunol. 1999 Dec;104(6):1215-22. 


    These protocols are for reference only. InvivoChem does not independently validate these methods.

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