Bavisant dihydrochloride hydrate

Alias: Bavisant dihydrochloride hydrate; JNJ-31001074-AAC; JNJ 31001074-AAC; JNJ31001074-AAC
Cat No.:V4516 Purity: ≥98%
Bavisant dihydrochloride hydrate (also known as JNJ-31001074 dihydrochloride hydrate) is a novel, highly selective, orally bioactive antagonist of the human H3 receptor with a novel mechanism of action which involves wakefulness and cognition.
Bavisant dihydrochloride hydrate Chemical Structure CAS No.: 1103522-80-0
Product category: Histamine Receptor
This product is for research use only, not for human use. We do not sell to patients.
Size Price Stock Qty
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Other Forms of Bavisant dihydrochloride hydrate:

  • JNJ-31001074
  • Bavisant dihydrochloride
Official Supplier of:
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Purity & Quality Control Documentation

Purity: ≥98%

Product Description

Bavisant dihydrochloride hydrate (also known as JNJ-31001074 dihydrochloride hydrate) is a novel, highly selective, orally bioactive antagonist of the human H3 receptor with a novel mechanism of action which involves wakefulness and cognition. It might be applied as an ADHD treatment. Non-histamine neurons contain histamine H3 receptors, which control other neurotransmitters like acetylcholine and norepinephrine. This suggests that H3 antagonists may be able to reduce impulsivity and enhance attention. According to research, H3 receptor antagonists may have a special therapeutic effect and provide a significant alternative for the treatment of ADHD because of their novel mechanism of action.

Biological Activity I Assay Protocols (From Reference)
These protocols are for reference only. InvivoChem does not independently validate these methods.
Physicochemical Properties
Molecular Formula
C19H31CL2N3O3
Molecular Weight
420.37374329567
Exact Mass
419.17
Elemental Analysis
C, 54.29; H, 7.43; Cl, 16.87; N, 10.00; O, 11.42
CAS #
1103522-80-0
Appearance
Solid powder
SMILES
C1CC1N2CCN(CC2)C(=O)C3=CC=C(C=C3)CN4CCOCC4.O.Cl.Cl
InChi Key
BLFBQJUVAGIUBL-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H27N3O2.2ClH.H2O/c23-19(22-9-7-21(8-10-22)18-5-6-18)17-3-1-16(2-4-17)15-20-11-13-24-14-12-20;;;/h1-4,18H,5-15H2;2*1H;1H2
Chemical Name
(4-cyclopropylpiperazin-1-yl)-[4-(morpholin-4-ylmethyl)phenyl]methanone;hydrate;dihydrochloride
Synonyms
Bavisant dihydrochloride hydrate; JNJ-31001074-AAC; JNJ 31001074-AAC; JNJ31001074-AAC
HS Tariff Code
2934.99.9001
Storage

Powder      -20°C    3 years

                     4°C     2 years

In solvent   -80°C    6 months

                  -20°C    1 month

Shipping Condition
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
Solubility Data
Solubility (In Vitro)
H2O: ≥ 50 mg/mL (~118.9 mM)
DMSO: ≥ 1 mg/mL (~2.4 mM)
Preparing Stock Solutions 1 mg 5 mg 10 mg
1 mM 2.3789 mL 11.8943 mL 23.7886 mL
5 mM 0.4758 mL 2.3789 mL 4.7577 mL
10 mM 0.2379 mL 1.1894 mL 2.3789 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.

Calculator

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An example of molarity calculation using the molarity calculator is shown below:
What is the mass of compound required to make a 10 mM stock solution in 5 ml of DMSO given that the molecular weight of the compound is 350.26 g/mol?
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What volume of a given 10 mM stock solution is required to make 25 ml of a 25 μM solution?
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g/mol

Molecular Weight Calculator allows you to calculate the molar mass and elemental composition of a compound, as detailed below:

Note: Chemical formula is case sensitive: C12H18N3O4  c12h18n3o4
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Definitions of molecular mass, molecular weight, molar mass and molar weight:
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In vivo Formulation Calculator (Clear solution)
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Calculation results

Working concentration mg/mL;

Method for preparing DMSO stock solution mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation:Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
             (2) Be sure to add the solvent(s) in order.

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