| Size | Price | Stock | Qty |
|---|---|---|---|
| 5mg |
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| 10mg |
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| 25mg |
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| 50mg |
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| 100mg |
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| Other Sizes |
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Purity: ≥98%
| ln Vitro |
Aureobasidin A stops the growth of yeast cells by depriving them of vital inositolphosphorylceramides and intoxicating them with ceramides[2].
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|---|---|
| References | |
| Additional Infomation |
Basifungin, also known as aureuobacidin A, is a phosphorylceramide synthase inhibitor,.
Aureobasidin A has been reported in Aureobasidium pullulans with data available. Basifungin is an orally available cyclic depsipeptide antibiotic produced by Aureobasidium pullulans that is a fungicide at low concentrations. Aureobasidin A inhibits inositol phosphorylceramide synthase, an enzyme that catalyzes a key step in fungal sphingolipid biosynthesis. This may inhibit fungal cell growth. |
| Molecular Formula |
C60H92N8O12
|
|---|---|
| Molecular Weight |
1117.44
|
| Exact Mass |
1100.69
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| Elemental Analysis |
C, 64.49; H, 8.30; N, 10.03; O, 17.18
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| CAS # |
127785-64-2
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| Related CAS # |
127785-64-2;
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| PubChem CID |
9919816
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| Appearance |
White to off-white solid powder
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| Density |
1.19g/cm3
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| Boiling Point |
1229.1ºC at 760 mmHg
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| Flash Point |
697.1ºC
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| Vapour Pressure |
0mmHg at 25°C
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| Index of Refraction |
1.574
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| LogP |
4.889
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| Hydrogen Bond Donor Count |
4
|
| Hydrogen Bond Acceptor Count |
11
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| Rotatable Bond Count |
13
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| Heavy Atom Count |
79
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| Complexity |
2110
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| Defined Atom Stereocenter Count |
11
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| SMILES |
O=C1[C@]2([H])C([H])([H])C([H])([H])C([H])([H])N2C([C@]([H])(C([H])([H])C2C([H])=C([H])C([H])=C([H])C=2[H])N(C([H])([H])[H])C([C@]([H])(C([H])([H])C2C([H])=C([H])C([H])=C([H])C=2[H])N([H])C([C@]([H])(C([H])(C([H])([H])[H])C([H])([H])[H])N(C([H])([H])[H])C([C@]([H])([C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])OC([C@]([H])(C(C([H])([H])[H])(C([H])([H])[H])O[H])N(C([H])([H])[H])C([C@]([H])(C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])N([H])C([C@]([H])(C([H])(C([H])([H])[H])C([H])([H])[H])N(C([H])([H])[H])C([C@@]([H])([C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])N1[H])=O)=O)=O)=O)=O)=O)=O)=O
|
| InChi Key |
BGBIMGBOAIOSPU-PHHQQPDVSA-N InChi Code
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| InChi Code |
InChI=1S/C60H92N8O12/c1-17-38(9)46(56(76)65(14)47(36(5)6)51(71)61-42(32-35(3)4)54(74)67(16)60(58(78)80-60)59(11,12)79)63-50(70)44-30-25-31-68(44)55(75)45(34-41-28-23-20-24-29-41)64(13)53(73)43(33-40-26-21-19-22-27-40)62-52(72)48(37(7)8)66(15)57(77)49(69)39(10)18-2/h19-24,26-29,35-39,42-49,69,79H,17-18,25,30-34H2,1-16H3,(H,61,71)(H,62,72)(H,63,70)/t38-,39?,42+,43+,44+,45+,46+,47+,48+,49?,60+/m1/s1
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| Chemical Name |
Valine, 3-hydroxy-N-(N-(N-(N-(1-(N-(N-(N-(2-hydroxy-3-methyl-1-oxopentyl)-N-methylvalyl)phenylalanyl)-N-methylphenylalanyl)prolyl)alloisoleucyl)-N-methylvalyl)leucyl)-N-methyl-, alpha-1-lactone
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| Synonyms |
Aureobasidin A; LY 295337; LY295337; NK 204 R106-1
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture and light. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~100 mg/mL (~90.79 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (2.27 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (2.27 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. View More
Solubility in Formulation 3: 10% DMSO+40% PEG300+5% Tween-80+45% Saline: ≥ 2.5 mg/mL (2.27 mM) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 0.8949 mL | 4.4745 mL | 8.9490 mL | |
| 5 mM | 0.1790 mL | 0.8949 mL | 1.7898 mL | |
| 10 mM | 0.0895 mL | 0.4475 mL | 0.8949 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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