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    Azelnidipine (UR12592, CS-905, CCRIS-8650)
    Azelnidipine (UR12592, CS-905, CCRIS-8650)

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V0563
    CAS #: 123524-52-7 Purity ≥98%

    Description: Azelnidipine (also called UR-12592, CS 905, Calblock and CCRIS 8650), a novel dihydropyridine derivative, is a 3rd generation and long-acting L-type calcium channel blocker, and an antihypertensive drug sold in Japan by Daiichi-Sankyo pharmaceuticals, Inc. Acute administration of azelnidipine prevents a sudden drop of cardiac function after acute stress. Unlike other L-type calcium channel blockers, azelnidipine causes minimal stimulation of the sympathetic nervous system despite its significant depressor effect. Azelnidipine may have a protective role in inflammation in atherosclerosis.

    References: Hypertens Res. 2003 Mar;26(3):201-8; Int J Pharm. 2008 Mar 3;351(1-2):55-60. 

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    Molecular Weight (MW)582.65 
    FormulaC33H34N4O6 
    CAS No.123524-52-7 
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 117 mg/mL (200.8 mM) 
    Water: <1 mg/mL
    Ethanol: 7 mg/mL (12.01 mM) 
    Other info

    Chemical Name: 3-(1-benzhydrylazetidin-3-yl) 5-isopropyl 2-amino-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

    InChi Key: ZKFQEACEUNWPMT-UHFFFAOYSA-N

    InChi Code: InChI=1S/C33H34N4O6/c1-20(2)42-32(38)27-21(3)35-31(34)29(28(27)24-15-10-16-25(17-24)37(40)41)33(39)43-26-18-36(19-26)30(22-11-6-4-7-12-22)23-13-8-5-9-14-23/h4-17,20,26,28,30,35H,18-19,34H2,1-3H3

    SMILES Code: O=C(C1=C(N)NC(C)=C(C(OC(C)C)=O)C1C2=CC=CC([N+]([O-])=O)=C2)OC3CN(C(C4=CC=CC=C4)C5=CC=CC=C5)C3

    SynonymsUR-12592; UR-12592; UR-12592; CS 905; CS-905; CS905; CCRIS 8650; CCRIS8650; CCRIS-8650; Azelnidipine; trade name CalBlock.


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    In Vitro

    In vitro activity: Azelnidipine is a newly developed long-acting calcium channel blocker with unique pharmacological features, e.g. cardiac slowing action and high affinity to vascular tissues, which distinguishes itself from other calcium channel blockers. Azelnidipine, thus, became a new generation of calcium channel blocker that can be used for the treatment of hypertensive patients with or without potential ischemic heart diseases. Because this new calcium antagonist is highly lipid soluble, it is retained in the vascular wall after clearance from the blood and continues to elicit a hypotensive effect.

    In VivoNA
    Animal modelNA
    Formulation & DosageNA
    References

    Hypertens Res. 2003 Mar;26(3):201-8; Int J Pharm. 2008 Mar 3;351(1-2):55-60.  


    These protocols are for reference only. InvivoChem does not independently validate these methods.

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