| Size | Price | Stock | Qty |
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| 250mg |
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| 500mg |
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| 1g |
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| 2g |
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| 5g |
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| 10g |
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Purity: ≥98%
Avobenzone (also known as Butyl methoxydibenzoylmethane, BF2AVB) is a dibenzoylmethane derivative that is oil soluble and frequently used in sunscreen products to absorb UVA rays. When combined with mineral UV absorbers like zinc oxide and titanium dioxide, it can degrade more quickly in light; however, this reaction can be mitigated with the proper coating of the mineral particles. To increase the stability of avobenzone, manganese-doped titanium dioxide might be preferable to undoped titanium dioxide. It creates colorful complexes when it reacts with minerals. A chelator is advised by avobenzone manufacturers such as DSM to stop this from occurring. Additionally, they advise against adding heavy metals, PABA and PABA esters, formaldehyde donors, iron and ferric salts, and heavy metals.
| ln Vitro |
Avobenzone (EC50=14.1 μM) encourages adipogenesis in hBM-MSCs significantly, with obesogenic chemicals serving as the positive control. During adipogenesis in hBM-MSCs, avobenzone (10 μM) significantly upregulates PPARγ mRNA levels[2].
Avobenzone (1-50 μM; 48 hours) inhibits human trophoblast cells' ability to proliferate[3]. Avobenzone (1-50 μM; 48 hours) brings HTR8/SVneo cells to apoptosis[3]. Avobenzone only demonstrates weak AR antagonistic and ERa agonism[4]. |
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| References |
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| Molecular Formula |
C20H22O3
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|---|---|
| Molecular Weight |
310.39
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| Exact Mass |
310.16
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| Elemental Analysis |
C, 77.39; H, 7.14; O, 15.46
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| CAS # |
70356-09-1
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| Related CAS # |
Avobenzone-13C,d3
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| Appearance |
White to light yellow crystalline powder
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| SMILES |
CC(C)(C)C1=CC=C(C=C1)C(=O)CC(=O)C2=CC=C(C=C2)OC
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| InChi Key |
XNEFYCZVKIDDMS-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C20H22O3/c1-20(2,3)16-9-5-14(6-10-16)18(21)13-19(22)15-7-11-17(23-4)12-8-15/h5-12H,13H2,1-4H3
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| Chemical Name |
1-(4-tert-butylphenyl)-3-(4-methoxyphenyl)propane-1,3-dione
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| Synonyms |
HSDB 7423; HSDB-7423; HSDB7423; Avobenzone; Avobenzonum; Parsol1789; Parsol-1789; Parsol 1789
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: (1) .This product requires protection from light (avoid light exposure) during transportation and storage. (2). Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
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| Solubility (In Vivo) |
Solubility in Formulation 1: 2.5 mg/mL (8.05 mM) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), suspension solution; with sonication.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (8.05 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.2218 mL | 16.1088 mL | 32.2175 mL | |
| 5 mM | 0.6444 mL | 3.2218 mL | 6.4435 mL | |
| 10 mM | 0.3222 mL | 1.6109 mL | 3.2218 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
| NCT Number | Recruitment | interventions | Conditions | Sponsor/Collaborators | Start Date | Phases |
| NCT05865431 | Completed | Drug: Zinc Oxide and Avobenzone | Sun Damaged Skin | University of California, Davis | March 17, 2017 | Not Applicable |
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