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    Apoptosis Activator 2
    Apoptosis Activator 2

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V0026
    CAS #: 79183-19-0Purity ≥98%

    Description: Apoptosis Activator 2 is a novel and potent small molecule apoptosis activator with IC50 value of about 4μM. Apoptosis Activator 2 is a cell permeable compound that promotes apoptosis by activating caspases in a cytochrome c- and Apaf-1-dependent manner. 20μM Apoptosis Activator 2 increases the fraction of Apaf-1 in the apoptosome when there is 0.15μM cytochrome c. Apoptosis Activator 2 was  found to induce the oligomerization of Apaf-1. Through the induction of apoptosis, Apoptosis Activator 2 notably induces caspase-3 activation, PARP cleavage and DNA fragmentation.

    References: Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7533-8; Neural Dev. 2009 Mar 16;4:11.

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    Molecular Weight (MW)306.14
    FormulaC15H9Cl2NO2
    CAS No.79183-19-0
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 61 mg/mL (199.25 mM)
    Water:<1 mg/mL (slightly soluble or insoluble)
    Ethanol: <1 mg/mL
    Other info

    Synonym: Apoptosis Activator 2; MDK83190; MDK-83190; MDK 83190; AAII; N-(3,4-dichlorobenzyl) Isatin; 

    Chemical Name: 1-[(3,4-dichlorophenyl)methyl]-1H-indole-2,3-dione

    InChi Key: KGRJPLRFGLMQMV-UHFFFAOYSA-N

    InChi Code: InChI=1S/C15H9Cl2NO2/c16-11-6-5-9(7-12(11)17)8-18-13-4-2-1-3-10(13)14(19)15(18)20/h1-7H,8H2

    SMILES Code: O=C1N(CC2=CC=C(Cl)C(Cl)=C2)C3=C(C=CC=C3)C1=O


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    In vitroApoptosis Activator 2 strongly induces caspase-3 activation, PARP cleavage, and DNA fragmentation which leads to the destruction of cells (Apaf-1 dependent) with IC50 of ~4 μM, inactive to HMEC, PREC, or MCF-10A cells.
    In vivoN/A
    FormulationN/A
    DosagesN/A
    AdministrationN/A
    ReferencesProc Natl Acad Sci U S A. 2003 Jun 24;100(13):7533-8. Epub 2003 Jun 13.


    These protocols are for reference only. InvivoChem does not independently validate these methods.

    Apoptosis Activator 2

    Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7533-8.
     

    Apoptosis Activator 2

    Compounds induce apoptosis in whole cells. Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7533-8. 
     

    Apoptosis Activator 2

    Compounds promote the oligomerization of Apaf-1. Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7533-8. 

    Apoptosis Activator 2

    Loss of Engrailed induces neurotrophin requirement in mesDA neurons. Neural Dev. 2009 Mar 16;4:11. 
     

    Apoptosis Activator 2

    Differential activation of Erk1/2 in mesDA neurons. Neural Dev. 2009 Mar 16;4:11. 
     

    Apoptosis Activator 2

    Erk1/2 activation is inversely correlated with P75NTR expression. Neural Dev.2009 Mar 16;4:11.


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