| Size | Price | Stock | Qty |
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| 10mg |
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| 25mg |
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| 50mg |
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| 100mg |
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| 250mg | |||
| Other Sizes |
| Targets |
PPAR-γ
Angeloylgomisin H targets PPAR-γ (Peroxisome proliferator-activated receptor gamma), activating it to improve insulin-stimulated glucose uptake. It also inhibits ornithine decarboxylase and acetylcholinesterase, enzymes involved in carcinogenic metabolism. |
|---|---|
| ln Vitro |
In vitro, Angeloylgomisin H improves insulin-stimulated glucose uptake by activating PPAR-γ. It inhibits ornithine decarboxylase and acetylcholinesterase activity. It also exhibits antioxidant, anti-inflammatory, and hepatoprotective activities.
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| ln Vivo |
In vivo, Angeloylgomisin H's PPAR-γ activation suggests potential for improving insulin sensitivity and treating type 2 diabetes. Its hepatoprotective and anti-inflammatory activities suggest potential for liver protection. However, specific in vivo data are limited.
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| Enzyme Assay |
In vitro non-cell enzyme assays for Angeloylgomisin H involve measuring the inhibition of ornithine decarboxylase and acetylcholinesterase activity using standard enzyme assays with specific substrates. The decrease in product formation is measured spectrophotometrically.
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| Cell Assay |
In vitro cell-based assays for Angeloylgomisin H use adipocytes or muscle cells to study its effects on glucose uptake. Cells are treated with the compound, and glucose uptake is measured using radiolabeled glucose or fluorescent glucose analogues. PPAR-γ activation is confirmed by reporter gene assays.
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| Animal Protocol |
In vivo animal studies for Angeloylgomisin H would employ models of type 2 diabetes, such as high-fat diet-fed mice, to study its effects on insulin sensitivity and glucose tolerance. Its hepatoprotective effects could be studied in models of liver injury, such as CCl₄-induced hepatotoxicity.
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| ADME/Pharmacokinetics |
Angeloylgomisin H has a molecular weight of 500.58 g/mol and a molecular formula of C₂₈H₃₆O₈. It has a purity of ≥98% and should be stored at 2-8°C for up to 24 months. It is practically insoluble in water (0.029 g/L). Detailed pharmacokinetic parameters have not been extensively characterized.
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| Toxicity/Toxicokinetics |
The toxicity profile of Angeloylgomisin H has not been fully characterized. As a natural compound, it is generally considered to have low toxicity. However, its potent biological activities suggest it should be used with caution.
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| References | |
| Additional Infomation |
Angeloyl schisandrin H is a tannin. It has been reported that Schisandra chinensis contains angeloyl schisandrin H, and relevant data is available. See also: Schisandra chinensis fruit (partial).
Angeloylgomisin H is a lignan from Schisandra chinensis that activates PPAR-γ and improves insulin-stimulated glucose uptake. It also inhibits enzymes involved in carcinogenic metabolism. Not approved for clinical use. |
| Molecular Formula |
C28H36O8
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|---|---|
| Molecular Weight |
500.5806
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| Exact Mass |
500.241
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| CAS # |
66056-22-2
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| Related CAS # |
66056-22-2
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| PubChem CID |
26204131
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| Appearance |
White to off-white solid
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| Density |
1.1±0.1 g/cm3
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| Boiling Point |
656.3±55.0 °C at 760 mmHg
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| Flash Point |
212.3±25.0 °C
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| Vapour Pressure |
0.0±2.1 mmHg at 25°C
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| Index of Refraction |
1.539
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| LogP |
4.92
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
8
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| Rotatable Bond Count |
8
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| Heavy Atom Count |
36
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| Complexity |
771
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| Defined Atom Stereocenter Count |
2
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| SMILES |
O([H])C1(C([H])([H])[H])C([H])([H])C2=C([H])C(=C(C(=C2C2=C(C(=C(C([H])=C2C([H])([H])C1([H])C([H])([H])[H])OC([H])([H])[H])OC([H])([H])[H])OC(/C(=C(/[H])\C([H])([H])[H])/C([H])([H])[H])=O)OC([H])([H])[H])OC([H])([H])[H])OC([H])([H])[H]
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| InChi Key |
ZSAUXCVJDYCLRS-XSIRQHFTSA-N
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| InChi Code |
InChI=1S/C28H36O8/c1-10-15(2)27(29)36-26-21-17(12-19(31-5)24(26)34-8)11-16(3)28(4,30)14-18-13-20(32-6)23(33-7)25(35-9)22(18)21/h10,12-13,16,30H,11,14H2,1-9H3/b15-10-/t16-,28-/m0/s1
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| Chemical Name |
[(9S,10S)-10-hydroxy-4,5,14,15,16-pentamethoxy-9,10-dimethyl-3-tricyclo[10.4.0.02,7]hexadeca-1(16),2,4,6,12,14-hexaenyl] (Z)-2-methylbut-2-enoate
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| Synonyms |
Angeloylgomisin H
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture and light. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO: ~250 mg/mL (~499.4 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.08 mg/mL (4.16 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.08 mg/mL (4.16 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.9977 mL | 9.9884 mL | 19.9768 mL | |
| 5 mM | 0.3995 mL | 1.9977 mL | 3.9954 mL | |
| 10 mM | 0.1998 mL | 0.9988 mL | 1.9977 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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