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    Andarine (GTx-007)
    Andarine (GTx-007)

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1761
    CAS #: 401900-40-1Purity ≥98%

    Description: Andarine (formerly known as GTx-007; S-4; GTx007; S4) is an orally bioactive and selective non-steroidal androgen receptor (AR) agonist, specifically a selective androgen receptor modulator (SARM), that has potential usefulness in muscle wasting and osteoporosis. It activates AR with a Ki of 4 nM and is tissue-selective for anabolic organs. Andarine is being investigated for treating conditions such as muscle wasting, osteoporosis and benign prostatic hypertrophy. In an animal model of benign prostatic hypertrophy, andarine was shown to reduce prostate weight with similar efficacy to finasteride, but without producing any reduction in muscle mass or anti-androgenic side effects. 

    References: J Pharmacol Exp Ther. 2003 Mar;304(3):1334-40; Endocrinology. 2004 Dec;145(12):5420-8.


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    Molecular Weight (MW)441.36
    FormulaC19H18F3N3O6
    CAS No.401900-40-1
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 88 mg/mL (199.4 mM)
    Water: <1 mg/mL
    Ethanol: 88 mg/mL (199.4 mM)
    Solubility (In vivo)30% PEG400+0.5% Tween80+5% Propylene glycol: 30 mg/mL 
    SynonymsGTx-007; S-4; GTx007; S4; GTx 007; S 4


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    In Vitro

    In vitro activity: Andarine stimulates AR-mediated transcription to 93% of that observed for 1 nM DHT at a concentration of 10 nM.

    In VivoAndarine exhibits potent and efficacious anabolic activity and results in dose-dependent stimulation of growth in prostate, seminal vesicles, and levator ani muscle with the ED50 of 0.43 mg/day, 0.55 mg/day, and 0.14 mg/day, respectively. Besides, Andarine shows no dose-dependent effect on castration-induced change in FSH, and partially suppresses LH production at dose rates of 0.5 mg/day or higher. In dogs administrated by intravenous doses of Andarine (0.1, 1, 3, and 10 mg/kg), the total body clearance (CL) ranged from 7.4 mL/min/kg to 3.1 mL/min/kg, volume of distribution at steady state (Vss) is 1.39 L/kg and half-life of Andarine is 229 minutes, respectively. In addition, oral bioavailability is 38%, 62% and 91% for the 10 mg/kg, 1 mg/kg and 0.1 mg/kg doses, respectively. Andarine demonstrates tissue-selective pharmacological activity and significantly decreased prostate weight to 79.4% at a concentration of 0.5 mg/day in intact rats. 
    Animal modelMale Sprague-Dawley rats and castrated rat model.
    Formulation & DosageDissolved in minimal amounts of ethanol and then diluted to final concentrations with PEG 300; ≤1 mg/day; Administered via osmotic pump.
    References

    J Pharmacol Exp Ther. 2003 Mar;304(3):1334-40; Endocrinology. 2004 Dec;145(12):5420-8.


    These protocols are for reference only. InvivoChem does not independently validate these methods.

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