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    Anagrelide HCl
    Anagrelide HCl

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V0789
    CAS #: 58579-51-4Purity ≥98%

    Description: Anagrelide HCl (formerly BL4162A; BL-4162A; BL-4162-A; trade names Agrylin/Xagrid, Shire and Thromboreductin), the hydrochloride salt of Anagrelide, is an approved drug used for the treatment of essential thrombocytosis (thrombocythemia) and overproduction of blood platelets. It has been reported that Anagrelide acts by inhibiting PDE-3 and phospholipase A but the exact mechanism of action remains unclear.

    References: Semin Thromb Hemost. 1997;23(4):379-83; N Engl J Med. 1988 May 19;318(20):1292-4.

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    Molecular Weight (MW)292.55
    CAS No.58579-51-4
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 14 mg/mL (47.9 mM)
    Water:<1 mg/mL
    Ethanol: <1 mg/mL
    Other info

    Chemical Name: Imidazo(2,1-b)quinazolin-2(3H)-one, 6,7-dichloro-1,5-dihydro-, monohydrochloride


    InChi Code: InChI=1S/C10H7Cl2N3O.ClH/c11-6-1-2-7-5(9(6)12)3-15-4-8(16)14-10(15)13-7;/h1-2H,3-4H2,(H,13,14,16);1H

    SMILES Code: O=C1NC2=NC3=C(C(Cl)=C(Cl)C=C3)CN2C1.[H]Cl

    SynonymsBL-4162A; Anagrelide hydrochloride; BL 4162A; BL-4162A; BL4162A; Agrylin; Xagrid; GALE-401; Thromboreductin

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    In Vitro

    In vitro activity: Anagrelide is an oral imidazoquinazoline agent with an anti-cyclic AMP phosphodiesterase activity and inhibits platelet aggregation in both humans and animals. Anagrelide works by inhibiting the maturation of platelets from megakaryocytes.

    Cell Assay: Anagrelide is an established platelet-reducing drug. Studies have also investigated the effects of anagrelide on platelets, indicating that platelet function is as important as platelet counts in ET

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    Semin Thromb Hemost. 1997;23(4):379-83; N Engl J Med. 1988 May 19;318(20):1292-4.

    These protocols are for reference only. InvivoChem does not independently validate these methods.

    Anagrelide HCl

    Proportion of patients continuing anagrelide treatment at 6 months: full analysis set. ANA, anagrelide; CRT, cytoreductive therapy;  Eur J Haematol. 2014 Feb; 92(2): 127–136.

    Anagrelide HCl

    Platelet responses by main subgroups: full analysis set. ANA, anagrelide; CRT, cytoreductive therapy; SPC, Summary of Product Characteristics. Eur J Haematol. 2014 Feb; 92(2): 127–136.


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