| Size | Price | Stock | Qty |
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| 10mg |
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| 50mg |
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| 100mg |
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| Other Sizes |
| ln Vivo |
Anabasine effectively restored damage at doses of 0.2 mg/kg (p<0.05) and 2 mg/kg (p<0.025). When taken alone, nectarine did not have any meaningful influence on response latency. In fact, the 0.06 mg/kg neocostalis dose significantly (p<0.05) aggravated dezocycline-induced impairment. None of these neophylline doses per se changed the accuracy of the selection. Individual dose comparisons showed that the 0.06 mg/kg dose of chrysanthine with dizozepine (6.7±2.6) resulted in a significant increase of non-responsive trials (p<0.05) compared to dizozepine alone (2.1±0.8) [1].
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| ADME/Pharmacokinetics |
Absorption, Distribution and Excretion
Anabasine is readily absorbed through the skin and mucous membranes. Metabolism/Metabolites The in vitro metabolite of (-)-methylanabasine in rats, rabbits, and guinea pigs is (-)-anabasine, which is then metabolized to 1'-N-hydroxyanabasine and anabassine 1'-δ-nitroketone. Metabolites of the lung microsomal components are similar. |
| Toxicity/Toxicokinetics |
Interactions
Anabasin enhances the sedative effects of risapene, apomorphine, and 5-hydroxytryptophan in frogs and inhibits the uptake of serotonin by human platelets. |
| References | |
| Additional Infomation |
(S)-Anabasin is the (S)-enantiomer of anabasin. (-)-Anabasin has been reported to be found in Nicotiana suaveolens, Verbascum songaricum, and other organisms with relevant data. Anabasin is a nicotine analogue, an alkaloid found in Nicotiana glauca, composed of a pyridine ring with a piperidine-2-yl substitution at the 3-position. Anabasin was once used as an industrial insecticide; due to the presence of trace amounts of anabasin in tobacco smoke, the detection of anabasin in urine can serve as an indicator of exposure to tobacco smoke. A piperidine-based plant-based insecticide. See also: Tobacco leaves (partial). Mechanism of Action: ...Anabasin acts on the ganglia of the insect central nervous system, promoting transsynaptic transmission. Low concentrations promote nerve conduction, while high concentrations block nerve conduction.
Anabassine has a neuromuscular blocking effect on isolated rat phrenic nerve-diaphragm, an effect partially antagonized by neostigmine. It is a depolarizing muscle relaxant with some characteristics of competitive muscle relaxants. Therapeutic Use Experimental Use: Anabassine (2 mg/kg/day, intraperitoneal injection, for 10 days) inhibited the inhibitory effect of co-administered hydrocortisone on the adrenocortical-pituitary system in rats. It also inhibited aseptic inflammation in rats (subplantar formalin injection); this anti-inflammatory activity appears to be due to activation of the adrenocortical-hypothalamic-pituitary system. Activation of the hormonal function of the adrenocortical-pituitary system may be helpful in patients with inflammation receiving glucocorticoid therapy. |
| Molecular Formula |
C10H14N2
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|---|---|
| Molecular Weight |
162.2316
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| Exact Mass |
162.116
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| CAS # |
494-52-0
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| Related CAS # |
(±) Anabasine;13078-04-1;Anabasine hydrochloride;53912-89-3
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| PubChem CID |
205586
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| Appearance |
Colorless to light yellow liquid
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| Density |
1,0455 g/cm3
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| Boiling Point |
270-272°C
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| Melting Point |
9°C
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| Flash Point |
93°C
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| Vapour Pressure |
0.00662mmHg at 25°C
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| Index of Refraction |
1.5430
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| LogP |
2.225
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
2
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| Rotatable Bond Count |
1
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| Heavy Atom Count |
12
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| Complexity |
136
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| Defined Atom Stereocenter Count |
1
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| SMILES |
N1CCCC[C@H]1C1C=NC=CC=1
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| InChi Key |
MTXSIJUGVMTTMU-JTQLQIEISA-N
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| InChi Code |
InChI=1S/C10H14N2/c1-2-7-12-10(5-1)9-4-3-6-11-8-9/h3-4,6,8,10,12H,1-2,5,7H2/t10-/m0/s1
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| Chemical Name |
3-[(2S)-piperidin-2-yl]pyridine
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~100 mg/mL (~616.41 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (15.41 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (15.41 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (15.41 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 6.1641 mL | 30.8204 mL | 61.6409 mL | |
| 5 mM | 1.2328 mL | 6.1641 mL | 12.3282 mL | |
| 10 mM | 0.6164 mL | 3.0820 mL | 6.1641 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
| NCT Number | Recruitment | interventions | Conditions | Sponsor/Collaborators | Start Date | Phases |
| NCT01303081 | Completed | Behavioral: Individual Rewards Behavioral: Fixed Deposits Behavioral: Chosen Deposits |
Tobacco Use Disorder | University of Pennsylvania | 2011-06 | Not Applicable |
| NCT01526265 | Completed | Behavioral: Usual Care Behavioral: Individual Rewards Behavioral: Fixed Deposits |
Tobacco Use Disorder | University of Pennsylvania | 2012-02 | Not Applicable |
| NCT04605458 | Recruiting | Combination Product: Contingency Management Combination Product: Standard Care |
Smoking Cessation | Medical University of South Carolina | 2020-11-25 | Not Applicable |
| NCT03473483 | Withdrawn | Other: SREC | Cardiovascular Risk Factor Nicotine Dependence Nicotine Dependence, Cigarettes Nicotine Withdrawal Tobacco Toxicity |
University of California, San Francisco | 2022-08-01 | Not Applicable |
| NCT05881304 | Recruiting | Device: Standardized research e-cigarette (SREC) | Electronic Cigarette Use | Massachusetts General Hospital | 2024-06-03 | Not Applicable |
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