| Size | Price | Stock | Qty |
|---|---|---|---|
| 10mg |
|
||
| 50mg |
|
||
| 100mg |
|
||
| 250mg |
|
||
| 500mg |
|
||
| Other Sizes |
|
| ln Vivo |
Anabasine effectively restored damage at doses of 0.2 mg/kg (p<0.05) and 2 mg/kg (p<0.025). When taken alone, nectarine did not have any meaningful influence on response latency. In fact, the 0.06 mg/kg neocostalis dose significantly (p<0.05) aggravated dezocycline-induced impairment. None of these neophylline doses per se changed the accuracy of the selection. Individual dose comparisons showed that the 0.06 mg/kg dose of chrysanthine with dizozepine (6.7±2.6) resulted in a significant increase of non-responsive trials (p<0.05) compared to dizozepine alone (2.1±0.8) [1].
|
|---|---|
| ADME/Pharmacokinetics |
Absorption, Distribution and Excretion
Anabasine is readily absorbed from the skin and from mucous membranes. Metabolism / Metabolites IN VITRO METABOLISM OF (-)-METHYLANABASINE BY RAT, RABBIT & GUINEA PIG GAVE (-)-ANABASINE WHICH WAS METABOLIZED TO 1'-N-HYDROXYANABASINE & ANABASINE 1'DELTA-NITRONE. METABOLIC PRODUCTS OF FORTIFIED LUNG MICROSOMAL FRACTIONS WERE SIMILAR. |
| Toxicity/Toxicokinetics |
Interactions
ANABASINE ENHANCED SEDATIVE ACTION OF RESERPINE, APOMORPHINE, & 5-HYDROXYTRYPTOPHAN IN FROGS & INHIBITED SEROTONIN UPTAKE BY HUMAN THROMBOCYTES. |
| References | |
| Additional Infomation |
(S)-anabasine is the (S)-enantiomer of anabasine.
(-)-Anabasine has been reported in Nicotiana suaveolens, Verbascum songaricum, and other organisms with data available. Anabasine is a nicotine analog that is an alkaloid found in tree tobacco (Nicotiana glauca) and is comprised of a pyridine substituted by a piperidin-2-yl group at position 3. Anabasine has been used as an industrial insecticide and, since it is present in trace amounts in tobacco smoke, its detection in urine can be used as an indicator of exposure to tobacco smoke. A piperidine botanical insecticide. See also: Tobacco Leaf (part of). Mechanism of Action ...ANABASINE AFFECT/S/ THE GANGLION OF THE INSECT CENTRAL NERVOUS SYSTEM, FACILITATING TRANS-SYNAPTIC CONDUCTION AT LOW CONCENTRATIONS AND BLOCKING CONDUCTION AT HIGHER LEVELS. ANABASINE EXERTED NEUROMUSCULAR BLOCKING EFFECT ON ISOLATED RAT PHRENIC NERVE-DIAPHRAGM WHICH COULD BE PARTIALLY ANTAGONIZED BY NEOSTIGMINE. IT IS A DEPOLARIZING MUSCLE RELAXANT WITH SOME CHARACTERISTICS OF COMPETITIVE MUSCLE RELAXANTS. Therapeutic Uses EXPTL USE: ANABASINE (2 MG/KG/DAY, IP FOR 10 DAYS) INHIBITED THE INHIBITORY EFFECT OF CONCOMITANTLY ADMIN HYDROCORTISONE ON ADRENAL CORTEX-PITUITARY SYSTEM IN RATS. IT ALSO INHIBITED ASEPTIC INFLAMMATION (FORMALIN INJECTION UNDER THE PLANTAR APONEUROSIS OF THE FOOT) IN RATS; THIS ANTIINFLAMMATORY ACTIVITY APPEARS TO BE DUE TO ACTIVATION OF ADRENAL CORTEX-HYPOTHALAMUS-PITUITARY SYSTEM. IT MAY BE USEFUL TO ACTIVATE THE HORMONAL FUNCTION OF ADRENAL CORTEX-PITUITARY SYSTEM DURING GLUCOCORTICOID THERAPY IN PATIENTS WITH INFLAMMATION. |
| Molecular Formula |
C10H14N2
|
|---|---|
| Molecular Weight |
162.2316
|
| Exact Mass |
162.116
|
| CAS # |
494-52-0
|
| Related CAS # |
(±) Anabasine;13078-04-1;Anabasine hydrochloride;53912-89-3
|
| PubChem CID |
205586
|
| Appearance |
Colorless to light yellow liquid
|
| Density |
1,0455 g/cm3
|
| Boiling Point |
270-272°C
|
| Melting Point |
9°C
|
| Flash Point |
93°C
|
| Vapour Pressure |
0.00662mmHg at 25°C
|
| Index of Refraction |
1.5430
|
| LogP |
2.225
|
| Hydrogen Bond Donor Count |
1
|
| Hydrogen Bond Acceptor Count |
2
|
| Rotatable Bond Count |
1
|
| Heavy Atom Count |
12
|
| Complexity |
136
|
| Defined Atom Stereocenter Count |
1
|
| SMILES |
N1CCCC[C@H]1C1C=NC=CC=1
|
| InChi Key |
MTXSIJUGVMTTMU-JTQLQIEISA-N
|
| InChi Code |
InChI=1S/C10H14N2/c1-2-7-12-10(5-1)9-4-3-6-11-8-9/h3-4,6,8,10,12H,1-2,5,7H2/t10-/m0/s1
|
| Chemical Name |
3-[(2S)-piperidin-2-yl]pyridine
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO : ~100 mg/mL (~616.41 mM)
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (15.41 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (15.41 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (15.41 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 6.1641 mL | 30.8204 mL | 61.6409 mL | |
| 5 mM | 1.2328 mL | 6.1641 mL | 12.3282 mL | |
| 10 mM | 0.6164 mL | 3.0820 mL | 6.1641 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
| NCT Number | Recruitment | interventions | Conditions | Sponsor/Collaborators | Start Date | Phases |
| NCT01303081 | Completed | Behavioral: Individual Rewards Behavioral: Fixed Deposits Behavioral: Chosen Deposits |
Tobacco Use Disorder | University of Pennsylvania | 2011-06 | Not Applicable |
| NCT01526265 | Completed | Behavioral: Usual Care Behavioral: Individual Rewards Behavioral: Fixed Deposits |
Tobacco Use Disorder | University of Pennsylvania | 2012-02 | Not Applicable |
| NCT04605458 | Recruiting | Combination Product: Contingency Management Combination Product: Standard Care |
Smoking Cessation | Medical University of South Carolina | 2020-11-25 | Not Applicable |
| NCT03473483 | Withdrawn | Other: SREC | Cardiovascular Risk Factor Nicotine Dependence Nicotine Dependence, Cigarettes Nicotine Withdrawal Tobacco Toxicity |
University of California, San Francisco | 2022-08-01 | Not Applicable |
| NCT05881304 | Recruiting | Device: Standardized research e-cigarette (SREC) | Electronic Cigarette Use | Massachusetts General Hospital | 2024-06-03 | Not Applicable |
|
|
|
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
