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Description: Amiodarone HCl (formerly NSC-85442; NSC85442; NSC 85442; Cordarone), the hydrochloride salt of amiodarone, is an antiarrhythmic drug used to treat and prevent an irregular heartbeat. It acts as a sodium/potassium-ATPase inhibitor and an autophagy activator used to treat various types of cardiac dysrhythmias.
References: Cardiovasc Res. 1997 Jul;35(1):13-29.
Chemical Name: 2-Butyl-3-benzofuryl 4-(2-(diethylamino)ethoxy)-3,5-diiodophenyl ketone hydrochloride
InChi Key: ITPDYQOUSLNIHG-UHFFFAOYSA-N
InChi Code: InChI=1S/C25H29I2NO3.ClH/c1-4-7-11-22-23(18-10-8-9-12-21(18)31-22)24(29)17-15-19(26)25(20(27)16-17)30-14-13-28(5-2)6-3;/h8-10,12,15-16H,4-7,11,13-14H2,1-3H3;1H
SMILES Code: O=C(C1=C(CCCC)OC2=CC=CC=C12)C3=CC(I)=C(OCCN(CC)CC)C(I)=C3.[H]Cl
NSC 85442; Amiodarone hydrochloride; NSC-85442; NSC85442;
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2
In vitro activity: Amiodarone possesses an inhibitory effect on the fast sodium channel as well as on the slow calcium channel. Amiodarone also has non-competitive antisympathetic effects, and modulates thyroid function and phospholipid metabolism. Amiodarone penetrates deeply into the lipid matrix of the membrane, and is released from cardiac tissues very slowly when washed out. Amiodarone (44–88 μM) depresses Vmax of guinea pig papillary muscle without affecting the resting membrane potential, and that this Vmax inhibition is enhanced in a frequency- or use-dependent manner like Class I antiarrhythmic drugs. Amiodarone (50–88 μM) is also found to suppress the depolarization-induced spontaneous action potentials (abnormal automaticity) in ventricular muscles and in Purkinje fibers.
Cardiovasc Res. 1997 Jul;35(1):13-29.
Purity ≥98%
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