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    Amiodarone HCl (NSC 85442)
    Amiodarone HCl (NSC 85442)

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1672
    CAS #: 19774-82-4Purity ≥98%

    Description: Amiodarone HCl (formerly NSC-85442; NSC85442; NSC 85442; Cordarone), the hydrochloride salt of amiodarone, is an antiarrhythmic drug used to treat and prevent an irregular heartbeat. It acts as a sodium/potassium-ATPase inhibitor and an autophagy activator used to treat various types of cardiac dysrhythmias.  

    References: Cardiovasc Res. 1997 Jul;35(1):13-29.

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    Molecular Weight (MW)681.77
    CAS No.19774-82-4
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 23 mg/mL (33.7 mM)     
    Water: <1 mg/mL
    Ethanol: 11 mg/mL (16.1 mM)
    Other info

    Chemical Name: 2-Butyl-3-benzofuryl 4-(2-(diethylamino)ethoxy)-3,5-diiodophenyl ketone hydrochloride


    InChi Code: InChI=1S/C25H29I2NO3.ClH/c1-4-7-11-22-23(18-10-8-9-12-21(18)31-22)24(29)17-15-19(26)25(20(27)16-17)30-14-13-28(5-2)6-3;/h8-10,12,15-16H,4-7,11,13-14H2,1-3H3;1H

    SMILES Code: O=C(C1=C(CCCC)OC2=CC=CC=C12)C3=CC(I)=C(OCCN(CC)CC)C(I)=C3.[H]Cl           


    NSC 85442; Amiodarone hydrochloride; NSC-85442; NSC85442; 

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    In Vitro

    In vitro activity: Amiodarone possesses an inhibitory effect on the fast sodium channel as well as on the slow calcium channel. Amiodarone also has non-competitive antisympathetic effects, and modulates thyroid function and phospholipid metabolism. Amiodarone penetrates deeply into the lipid matrix of the membrane, and is released from cardiac tissues very slowly when washed out. Amiodarone (44–88 μM) depresses Vmax of guinea pig papillary muscle without affecting the resting membrane potential, and that this Vmax inhibition is enhanced in a frequency- or use-dependent manner like Class I antiarrhythmic drugs. Amiodarone (50–88 μM) is also found to suppress the depolarization-induced spontaneous action potentials (abnormal automaticity) in ventricular muscles and in Purkinje fibers.

    In VivoAmiodarone (1.25–25 mg/kg) results in a decrease in sinus rate, a prolongation of effective and functional refractory periods of the atrioventricular node, and a frequency-dependent conduction delay in the atrioventricular node and in the ventricle of anesthetized dogs. Amiodarone (50 mg/kg/day, i.p. for 3–4 weeks) results in significant decreases in the current density of iK and ito in ventricular cells without affecting iCa and iK1 densities in rabbit. Amiodarone (AM) inhibits intracellular conversion from thyroxine (T4) to triiodothyronine (T3) via 5′-deiodination (5′DI) without affecting intracellular conversion from T4 to reverse T3 (rT3). 
    Animal modelRabbits
    Formulation & Dosage50 mg/kg/day, i.p.

    Cardiovasc Res. 1997 Jul;35(1):13-29.

    These protocols are for reference only. InvivoChem does not independently validate these methods.


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