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    InvivoChem Cat #: V0785
    CAS #: 317-34-0Purity ≥98%

    Description: Aminophylline (also known as Phyllocontin; Euphyllin; Truphylline), a bronchodilator composed of theophyllineand ethylenediamine in 2:1 ratio, is a novel, potent, competitive nonselective phosphodiesterase/PDE inhibitor with an IC50 of 0.12 mM. It is also a nonselective adenosine receptor antagonist. Aminophylline is used to treat wheezing, shortness of breath, and difficulty breathing caused by asthma, chronic bronchitis, emphysema.

    References: Acad Emerg Med. 2003 Mar;10(3):192-7.

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    Molecular Weight (MW)420.43
    CAS No.317-34-0
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 53 mg/mL (126.1 mM)
    Water: 84 mg/mL (199.8 mM)
    Ethanol: <1 mg/L
    Chemical Name1,3-Dimethyl-7H-purine-2,6-dione; ethane-1,2-diamine
    SynonymsCardophyllin; Aminophyllin; Aminophylline; Theophyllamine; Phyllocontin; Euphyllin; Truphylline; Minomal R 175 mg tab; Minomal R 350 mg tab; Minomal SR 600 mg tab 

    Chemical Name: 1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione compound with ethane-1,2-diamine (2:1)


    InChi Code: InChI=1S/2C7H8N4O2.C2H8N2/c2*1-10-5-4(8-3-9-5)6(12)11(2)7(10)13;3-1-2-4/h2*3H,1-2H3,(H,8,9);1-4H2

    SMILES Code: CN1C2=C(NC=N2)C(N(C)C1=O)=O.CN3C4=C(NC=N4)C(N(C)C3=O)=O.NCCN

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    In Vitro

    In vitro activity: Aminophylline causes bronchodilation, diuresis, central nervous system and cardiac stimulation, and gastric acid secretion by blocking phosphodiesterase which increases tissue concentrations of cyclic adenosine monophosphate (cAMP) which in turn promotes catecholamine stimulation of lipolysis, glycogenolysis, and gluconeogenesis, and induces release of epinephrine from adrenal medulla cells.

    Kinase Assay: Aminophylline is a competitive nonselective phosphodiesterase inhibitor which raises intracellular cAMP, activates PKA, inhibits TNF-alpha and leukotriene[14] synthesis, and reduces inflammation and innate immunity and nonselective adenosine receptor antagonist.

    References Acad Emerg Med. 2003 Mar;10(3):192-7.

    These protocols are for reference only. InvivoChem does not independently validate these methods.


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