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Description: Aminophylline (also known as Phyllocontin; Euphyllin; Truphylline), a bronchodilator composed of theophyllineand ethylenediamine in 2:1 ratio, is a novel, potent, competitive nonselective phosphodiesterase/PDE inhibitor with an IC50 of 0.12 mM. It is also a nonselective adenosine receptor antagonist. Aminophylline is used to treat wheezing, shortness of breath, and difficulty breathing caused by asthma, chronic bronchitis, emphysema.
References: Acad Emerg Med. 2003 Mar;10(3):192-7.
Chemical Name: 1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione compound with ethane-1,2-diamine (2:1)
InChi Key: FQPFAHBPWDRTLU-UHFFFAOYSA-N
InChi Code: InChI=1S/2C7H8N4O2.C2H8N2/c2*1-10-5-4(8-3-9-5)6(12)11(2)7(10)13;3-1-2-4/h2*3H,1-2H3,(H,8,9);1-4H2
SMILES Code: CN1C2=C(NC=N2)C(N(C)C1=O)=O.CN3C4=C(NC=N4)C(N(C)C3=O)=O.NCCN
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2
In vitro activity: Aminophylline causes bronchodilation, diuresis, central nervous system and cardiac stimulation, and gastric acid secretion by blocking phosphodiesterase which increases tissue concentrations of cyclic adenosine monophosphate (cAMP) which in turn promotes catecholamine stimulation of lipolysis, glycogenolysis, and gluconeogenesis, and induces release of epinephrine from adrenal medulla cells.
Kinase Assay: Aminophylline is a competitive nonselective phosphodiesterase inhibitor which raises intracellular cAMP, activates PKA, inhibits TNF-alpha and leukotriene[14] synthesis, and reduces inflammation and innate immunity and nonselective adenosine receptor antagonist.
Purity ≥ 98%