| Size | Price | Stock | Qty |
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| 500mg |
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| 1g |
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| 5g |
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| 10g |
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Aminophylline (also known as Phyllocontin; Euphyllin; Truphylline), a bronchodilator composed of theophyllineand ethylenediamine in 2:1 ratio, is a novel, potent, competitive nonselective phosphodiesterase/PDE inhibitor with an IC50 of 0.12 mM. It is also a nonselective adenosine receptor antagonist. Aminophylline is used to treat wheezing, shortness of breath, and difficulty breathing caused by asthma, chronic bronchitis, emphysema.
| ln Vitro |
The bronchodilator theophylline is combined in a 2:1 ratio with ethylenediamine to form aminophylline. Aminophylline is typically found as a dihydrate, and the ethylenediamine increases solubility. Theophylline is more potent and has a longer half-life than aminophylline. It is most frequently used to treat airway obstruction brought on by COPD or asthma. Off-label, it is employed in nuclear stress testing as a reversal agent. Aminophylline is a phosphodiesterase inhibitor and nonselective antagonist of adenosine receptors. An extracellular messenger found in the body that can control myocardial oxygen requirements is adenosine. It works by blocking atrioventricular node conduction, increasing coronary artery blood flow, slowing heart rate, suppressing cardiac automaticity, and reducing the effects of β-adrenergic on contractility through cellular surface receptors that alter intracellular signaling pathways. Additionally, circulating catecholamines' chronotropic and ionotropic effects are countered by adenosine. All things considered, adenosine lowers the heart's contraction force and rate, which increases blood flow to the heart muscle. This mechanism (meant to protect the heart) may result in atropine-resistant refractory bradyasystole under certain conditions. The effects of adenosine vary with concentration. Aminophylline and other methylxanthines are competitive antagonists of adenosine receptors. Adenosine's cardiac effects are competitively inhibited by aminophylline at the cell surface receptors. It consequently raises contractility and heart rate.
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| References |
[1]. Ming-Chih Yu, et al. Luteolin, a non-selective competitive inhibitor of phosphodiesterases 1-5, displaced [3H]-rolipram from high-affinity rolipram binding sites and reversed xylazine/ketamine-induced anesthesia. ur J Pharmacol. 2010 Feb 10;627(1-3):269-75.
[2]. E Tai, et al. Response of blood gas tensions to aminophylline and isoprenaline in patients with asthma. Thorax. 1967 Nov;22(6):543-9. [3]. Daly JW, et al. Adenosine receptors: development of selective agonists and antagonists. Prog Clin Biol Res. 1987;230:41-63. |
| Molecular Formula |
C16H24N10O4
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|---|---|
| Molecular Weight |
420.43
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| CAS # |
317-34-0
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| Related CAS # |
58-55-9 (free);317-34-0 (EDA);
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| SMILES |
CN1C2=C(NC=N2)C(N(C)C1=O)=O.CN3C4=C(NC=N4)C(N(C)C3=O)=O.NCCN
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| InChi Key |
FQPFAHBPWDRTLU-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/2C7H8N4O2.C2H8N2/c2*1-10-5-4(8-3-9-5)6(12)11(2)7(10)13;3-1-2-4/h2*3H,1-2H3,(H,8,9);1-4H2
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| Chemical Name |
1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione compound with ethane-1,2-diamine (2:1)
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| Synonyms |
Cardophyllin; Aminophyllin; Aminophylline; Theophyllamine; Phyllocontin; Euphyllin; Truphylline; Minomal R 175 mg tab; Minomal R 350 mg tab; Minomal SR 600 mg tab
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
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| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.3785 mL | 11.8926 mL | 23.7852 mL | |
| 5 mM | 0.4757 mL | 2.3785 mL | 4.7570 mL | |
| 10 mM | 0.2379 mL | 1.1893 mL | 2.3785 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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