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    Almotriptan Malate (LAS 31416)
    Almotriptan Malate (LAS 31416)

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1027
    CAS #: 181183-52-8 Purity ≥98%

    Description: Almotriptan Malate (formerly LAS31416; LAS-31416; Almogran; Amignul; Almotrex; Axert), the maleate salt of Almotriptan which is an approved anti-migraine drug, is a potent and selective 5-hydroxytryptamine1B/1D (5-HT1B/1D) receptor agonist. It is a triptan drug developed by Almirall for the treatment of heavy migraine headache in adults. Almotriptan acts by binding to the receptor which leads to vasoconstriction of the cranial blood vessels and thus affects the redistribution of cranial blood flow. It significantly increases cerebral blood flow and reduces blood flow through extracerebral cranial vessels.

    References: J Pharm Bioallied Sci. 2014 Oct;6(4):267-77; J Pharm Biomed Anal. 2013 Jul-Aug;81-82:160-7.

    Related CAS #: 181183-52-8(Almotriptan Malate); 154323-57-6 (free base)  

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    Molecular Weight (MW)469.55 
    CAS No.181183-52-8 
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 94 mg/mL (200.2 mM) 
    Water: <1 mg/mL
    Ethanol: 53 mg/mL (112.9 mM) 
    Other info

    Chemical Name: N,N-dimethyl-2-(5-((pyrrolidin-1-ylsulfonyl)methyl)-1H-indol-3-yl)ethan-1-amine 2-hydroxysuccinate


    InChi Code: InChI=1S/C17H25N3O2S.C4H6O5/c1-19(2)10-7-15-12-18-17-6-5-14(11-16(15)17)13-23(21,22)20-8-3-4-9-20;5-2(4(8)9)1-3(6)7/h5-6,11-12,18H,3-4,7-10,13H2,1-2H3;2,5H,1H2,(H,6,7)(H,8,9)


    SynonymsLAS 31416; Almogran; Almotrex; LAS31416; LAS-31416; Amignul; Axert; Almotriptan Malate.

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    Almotriptan Malate

    Powder X-ray diffractograms of (a) Pure almotriptan malate (b) Blank microspheres and (c) Drug - loaded microspheres. J Pharm Bioallied Sci. 2014 Oct;6(4):267-77. 
    Almotriptan Malate
    In vitro drug diffusion profile of microsphere formulation AGM1 to AGM4 (a) and AGM5 to AGM8 (b). J Pharm Bioallied Sci. 2014 Oct;6(4):267-77. 
    Almotriptan Malate
    Plot of amount of drug released versus square root of time (Higuchi plot) for formulation AGM1 to AGM4 (a) and AGM5 to AGM8 (b). J Pharm Bioallied Sci. 2014 Oct;6(4):267-77. 


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