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Purity: ≥98%
Allopregnanolone [5α-pregnan-3α-ol-20-one or 3α,5α-tetrahydroprogesterone (3α,5α-THP), or SAGE-547, Brexanolone, zulresso and Allotetrahydroprogesterone] is a progesterone metabolite that serves as an allosteric modulator of the GABA (γ-aminobutyric acid) receptor. It has the potential for the treatment of Alzheimer’s Disease, epilepsy and depression. Allopregnanolone is an endogenous inhibitory pregnane neurosteroid that is synthesized from progesterone. Allopregnanolone has effects similar to those of other positive allosteric modulators of the GABA action at GABAA receptor such as the benzodiazepines, including anxiolytic, sedative, and anticonvulsant activity. Endogenously produced allopregnanolone exerts a pivotal neurophysiological role by fine-tuning of GABAA receptor and modulating the action of several positive allosteric modulators and agonists at GABAA receptor.
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| References |
J Neurosci.2005 May 11;25(19):4706-18;PLoS One.2015 Jun 3;10(6):e0128313;Neuroscience.2013 Jul 23;243:64-75.
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| Molecular Formula |
C21H34O2
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| Molecular Weight |
318.49
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| CAS # |
516-54-1
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| Related CAS # |
516-54-1;
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| SMILES |
O=C(C)[C@H]1CC[C@@]2([H])[C@]3([H])CC[C@@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C
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| Synonyms |
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
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| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.1398 mL | 15.6991 mL | 31.3982 mL | |
| 5 mM | 0.6280 mL | 3.1398 mL | 6.2796 mL | |
| 10 mM | 0.3140 mL | 1.5699 mL | 3.1398 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
 Rabbit plasma and brain concentration-time profiles of allopregnanolone following intravenous (IV) bolus or transdermal (TD) administration.PLoS One.2015 Jun 3;10(6):e0128313. |
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 Mouse plasma and brain concentration-time profiles of allopregnanolone following intravenous (IV), subcutaneous (SC) and transdermal (TD) administration.PLoS One.2015 Jun 3;10(6):e0128313. |
 Subcutaneous Allo increased BrdU incorporation and PCNA protein expression in male mouse AD model.PLoS One.2015 Jun 3;10(6):e0128313. |
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