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    InvivoChem Cat #: V0821
    CAS #: 72-48-0Purity ≥98%

    Description: Alizarin is a naturally occuring and anthraquinone-based dye extracted from the roots of madder plant. It has been widely used as a pigment in textile fabrics and paintings.  Alizarin also exhibits antioxidant activity. It can be used for detecting the presence of calcium salts. Alizarin belongs to the anthraquinone group. It is a chelator for calcium and is commonly used to stain the calcifying or calcio-receptive zone of the collagenous matrix where calcium salts are being deposited. On the other hand, the Alizarin complexone is used for bone staining in vivo to study bone remodeling. Alizarin is proved to have anti-tumor efficacy. It suppresses the cell growth of the prostate cancer, breast cancer and osteosarcoma cell lines in vitro.

    References: Mutat Res. 2002 Oct 31;508(1-2):147-56.

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    Molecular Weight (MW)240.21
    CAS No.72-48-0
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 48 mg/mL (199.8 mM)
    Water:<1 mg/mL
    Ethanol: <1 mg/mL

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    In Vitro

    In vitro activity: Alizarin weakly inhibits CYP2A6 and CYP2E1. Alizarin shows competitive inhibition against CYP1B1 with Ki of 0.5 μM. Alizarin reduces the mutagenicity of MeIQx, which induced by each CYP1A2 or CYP1B1, while does not effectively reduce the mutation induced by B[a]P. Alizarin exhibits antioxidants against iodophenol-derived phenoxyl radicals, superoxide anion radicals and lipid peroxidation in rat liver microsomes.

    Cell Assay: Alizarin is proved to have anti-tumor efficacy. It suppresses the cell growth of the prostate cancer, breast cancer and osteosarcoma cell lines in vitro. Among these, the osteosarcoma cells appear to be most sensitive. The IC50 values of Alizarin against three osteosarcoma cell lines Saos-2, MG-63 and U-2 OS are 27.5, 29 and 69.9μg/ml, respectively. Alizarin inhibits the cell growth through cell proliferation blockade rather than induction of apoptosis. It inhibits the phosphorylation of ERK. In addition, Alizarin is also found to induce S-phase arrest as well as a decrease of the G0/G1 and G2/M phases.

    In VivoAlizarin also reduces the hepatic content of thiobarbituric acid-reactive substances and the serum level of alanine aminotransferase in poisoned animals
    Animal model
    Formulation & Dosage

    Mutat Res. 2002 Oct 31;508(1-2):147-56.

    These protocols are for reference only. InvivoChem does not independently validate these methods.


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