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    Alendronate sodium hydrate
    Alendronate sodium hydrate

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V4560
    CAS #: 121268-17-5Purity ≥98%

    Description: Alendronate sodium hydrate, the sodium salt of alendronate, is a novel and potent farnesyl diphosphate synthase inhibitor with IC50 of 460 nM. Alendronate sodium is a second generation bisphosphonate and synthetic analog of pyrophosphate with bone anti-resorption activity. Alendronate sodium binds to and inhibits the activity of geranyltranstransferase (farnesyl pyrophosphate synthetase), an enzyme involved in terpenoid biosynthesis. Inhibition of this enzyme prevents the biosynthesis of isoprenoid lipids (FPP and GGPP) that are donor substrates of farnesylation and geranylgeranylation during the post-translational modification of small GTPase signalling proteins, which is important in the process of osteoclast turnover. As a result, osteoclast activity is inhibited and bone resorption and turnover are reduced. 

    ReferencesProc Natl Acad Sci U S A. 1999 Jan 5;96(1):133-8.


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    Alendronate sodium hydrate

    Name: Alendronate sodium
    CAS#: 121268-17-5
    Chemical Formula: C4H18NNaO10P2
    Exact Mass:
    Molecular Weight: 325.12
    Elemental Analysis: C, 14.78; H, 5.58; N, 4.31; Na, 7.07; O, 49.21; P, 19.05
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Technical InformationSynonym: MK 217; MK-217; G-704650 Adronat; Alendronate; Alendronic Acid Monosodium Salt Trihydrate. trade names: Fosamax; Adronat; Alendros; Onclast. Code names: G704650; MK217.
    IUPAC/Chemical Name: (4-amino-1-hydroxybutylidene) bisphosphonic acid monosodium salt trihydrate.
    InChi Key: DCSBSVSZJRSITC-UHFFFAOYSA-M
    InChi Code: InChI=1S/C4H13NO7P2.Na.3H2O/c5-3-1-2-4(6,13(7,8)9)14(10,11)12;;;;/h6H,1-3,5H2,(H2,7,8,9)(H2,10,11,12);;3*1H2/q;+1;;;/p-1
    SMILES Code: OC(P([O-])(O)=O)(P(O)(O)=O)CCCN.[H]O[H].[H]O[H].[H]O[H].[Na+]


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