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    Albendazole (SKF-62979)
    Albendazole (SKF-62979)

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1620
    CAS #: 54965-21-8Purity ≥98%

    Description: Albendazole (formerly SKF-62979; SKF62979; SKF 62979; Zentel; Albenza; Eskazole; Valbazen), a benzimidazole analog and tubulin inhibitor, is an orally bioavailable anti-parasitic drug that has been approved for use in the treatment of various worm infestations such as giardiasis, neurocysticercosis, filariasis, hydatid disease, trichuriasis, pinworm disease, and ascariasis, among others. It acts as a tubulin inhibitor that binds to the colchicine-sensitive site of β-tubulin, thus inhibiting its polymerization or assembly into microtubules.

    ReferencesToxicol Appl Pharmacol. 1991 Jun 1;109(1):73-84; J Pharmacol Exp Ther. 2005 Dec;315(3):1036-45. 

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    Molecular Weight (MW)265.33 
    CAS No.54965-21-8 
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 17 mg/mL (64.1 mM) 
    Water: <1 mg/mL
    Ethanol: <1 mg/mL
    Other info

    Chemical Name: methyl N-(6-propylsulfanyl-1H-benzimidazol-2-yl)carbamate


    InChi Code: InChI=1S/C12H15N3O2S/c1-3-6-18-8-4-5-9-10(7-8)14-11(13-9)15-12(16)17-2/h4-5,7H,3,6H2,1-2H3,(H2,13,14,15,16)

    SMILES Code: CCCSC1=CC2=C(C=C1)N=C(N2)NC(=O)OC

    SynonymsSKF-62979; Albendazole; SKF62979; Zentel; SKF 62979; Albenza; Eskazole; Valbazen

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    In Vitro

    In vitro activity: Albendazole is reported to be teratogenic in rats, and is extensively metabolized to the sulfoxide derivative. Albendazole and its sulfoxide metabolite elicit an accumulation of cells in the mitotic phase of the cell cycle.

    In VivoAlbendazole causes an induction of hepatic activities of CYP1A1-associated ethoxyresorufin O-deethylase (EROD) 65 fold, CYP1A2-associated methoxyresorufin O-demethylase (MROD) 6 fold, CYP2B1-associated penthoxyresorufin O-dealkylase (PROD) 4 fold, CYP2B2-associated benzyloxyresorufin O-dealkylase (BROD) 14 fold, as well as a partial reduction of CYP2E1-associated 4-nitrophenol hydroxylase (4-NPH) activity in the rat. Albendazole is metabolized to its pharmacologically active sulfoxide metabolites by liver and lung microsomes from sheep and cattle, as well as by cattle intestinal microsomes. Albendazole (ABZ) is a benzimidazole derivative with a broad spectrum of activity against human and animal helminthe parasites. Albendazole and its metabolites are extensively distributed to the digestive tract, mainly into the abomasal fluid, after the i.v. and i.r. administrations. Albendazole and its active albendazole sulphoxide (ABZSO) metabolite are recovered in tapeworms collected from both i.v. and i.r. treated lambs. 
    Animal modelRats
    Formulation & Dosagei.v. and i.r. administrations.

    Toxicol Appl Pharmacol. 1991 Jun 1;109(1):73-84; J Pharmacol Exp Ther. 2005 Dec;315(3):1036-45.  

    These protocols are for reference only. InvivoChem does not independently validate these methods.


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