My cart
In the shopping cart is not goods, to choose and buy!
  • Product Name
  • Size
  • Quantity
  • Amount
    Selected items : 0 pieces Total : CHECK OUT()
    Agomelatine (S-20098; BAN, rINN; Valdoxan, Melitor, Thymanax)
    Agomelatine (S-20098; BAN, rINN; Valdoxan, Melitor, Thymanax)

    Price:
    Market Price:

    This product is for research use only, not for human use. We do not sell to patients.
    Number: - + Pieces(InventoryPieces)
    InvivoChem Cat #: V0974
    CAS #: 138112-76-2Purity ≥98%

    Description: Agomelatine (S20098; AGO-178; S-20098; AGO178; Valdoxan, Melitor, Thymanax) is a potent and specific agonist of MT1 and MT2 receptors with anti-depressive activity. It activates the isoforms of MT receptors such as CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2 with Kis of 0.1, 0.06, 0.12, and 0.27 nM, respectively. It is a unique antidepressant and is developed for treatment of major depressive disorder (MDD). It shows low affinities to cloned human 5-HT2A and 5-HT1A. In the in vivo studies, agomelatine causes increase of dopamine and noradrenaline levels via blocking the inhibitory input of 5-HT2C.

    References: Behav Brain Res. 2011 Mar 17;218(1):121-8; Prog Neuropsychopharmacol Biol Psychiatry. 2005 Jul;29(6):908-16.

    Related CAS: 1079389-42-6 (D6); 166526-99-4 (3-Hydroxy agomelatine); 1176316-99-6 (HCl); 824393-18-2 ((L(+)-Tartaric acid)

    Customer Validation
    Official Supplier of
    • VE
    • OF
    • YALE
    • hhmi
    • 香港大学
    Related Products
    Publications Citing InvivoChem Products
    • Physicochemical and Storage Information
    • Protocol
    • Quality Control Documentation
    • Related Biological Data
    • Customer Review
    Molecular Weight (MW)243.3 
    FormulaC15H17NO2 
    CAS No.138112-76-2 
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 49 mg/mL (201.4 mM)
    Water: <1 mg/mL
    Ethanol: 49 mg/mL (201.4 mM)
    SMILES Code CC(=O)NCCC1=CC=CC2=C1C=C(C=C2)OC
    Synonyms

    S20098; Valdoxan; Thymanax; Melitor; AGO 178; N-(2-(7-methoxy-1-naphthyl)ethyl)acetamide; S 20098; AGO-178; AGO178; S-20098

    Chemical Name: N-[2-(7-methoxynaphthalen-1-yl)ethyl]acetamide


    • Molarity Calculator
    • Dilution Calculator
    • The molarity calculator equation

      Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

      • Mass
      • Concentration
      • Volume
      • Molecular Weight *
      • =
      • ×
      • ×
    • The dilution calculator equation

      Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

      This equation is commonly abbreviated as: C1V1 = C2V2

      • Concentration (start)
      • ×
      • Volume (start)
      • =
      • Concentration (final)
      • ×
      • Volume (final)
      • ×
      • =
      • ×
      • C1
      •  
      • V1
      •  
      • C2
      •  
      • V2
    In Vitro

    In vitro activity: Agomelatine completely normalizes stress-affected cell survival and partly reverses reduced doublecortin expression in the hippocampus of rats subjected to chronic footshock stress.

    In VivoAgomelatine is effective in reversing the transgenic mouse behavioural changes noted in the Porsolt forced swim test as well as in the elevated plus maze. Agomelatine also markedly accelerates readjustment of circadian cycles of temperature and activity following an induced phase shift. Agomelatine enhances cell proliferation and neurogenesis in the ventral hippocampus (VH) of adult rats, a region pertinent to mood disorders. Agomelatine increases the ratio of mature vs immature neurons and enhances neurite outgrowth of granular cells in adult rats, suggesting an acceleration of maturation. Agomelatine also activates several cellular signals (extracellular signal-regulated kinase1/2, protein kinase B, and glycogen synthase kinase 3beta) known to be modulated by antidepressants and implicated in the control of proliferation/survival. Agomelatine enhances the time devoted to active social interaction in unfamiliar pairs of rats exposed to a novel environment. Agomelatine increases cell proliferation and neurogenesis in the ventral dentate gyrus of rats, a region notably implicated in response to emotion, which is consistent with the antidepressant-anxiolytic properties of Agomelatine. Agomelatine increases survival of newly formed neurons in the entire dentate gyrus of rats .
    Animal modelMouse
    Formulation & DosageN/A
    References

    Behav Brain Res. 2011 Mar 17;218(1):121-8; Prog Neuropsychopharmacol Biol Psychiatry. 2005 Jul;29(6):908-16. 


    These protocols are for reference only. InvivoChem does not independently validate these methods.

     

    Agomelatine

    Effects of CMS and agomelatine treatment on marble burying. Behav Brain Res. 2011 Mar 17;218(1):121-8. 
     

    Agomelatine

    Effects of CMS and agomelatine treatment on sucrose preference. Behav Brain Res. 2011 Mar 17;218(1):121-8. 
     

    Agomelatine


    评论

      Home Prev Next Last page / pices

      发评论

      ×
      Your information is safe with us. * Required Fields.
      Products are for research use only;  We do not sell to patients
      Tel: 1-708-310-1919
      Fax: 1-708-557-7486
      Subscribe to our E-newsletter
      • Name*
      • *
      • E-mail*
      • *
      • instructions:
      • *
      Copyright 2020 InvivoChem LLC | All Rights Reserved
      prompt
      Do you confirm the receipt?