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    Adefovir Dipivoxil (GS 0840)
    Adefovir Dipivoxil (GS 0840)

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1815
    CAS #: 142340-99-6 Purity ≥98%

    Description: Adefovir Dipivoxil (also known as GS 0840 and GS-0840; trade names Preveon and Hepsera), the dipivoxil formulation of adefovir, is a reverse transcriptase inhibitor, used in the treatment of chronic hepatitis B virus (HBV). It is an antiviral acyclic nucleoside phosphonate (ANP) analog and a dipivoxil formulation of adefovir, a nucleoside reverse transcriptase inhibitor analog of adenosine with activity against hepatitis B virus (HBV), herpes virus, and human immunodeficiency virus (HIV). Adefovir Dipivoxil is an orally-administered acyclic nucleotide analog reverse transcriptase inhibitor (ntRTI) that works by blocking reverse transcriptase for the treatment of hepatitis B. Adefovir dipivoxil is not effective against HIV-1. 

    References: Antiviral Res. 2002 Jul;55(1):27-40.

    Related CAS#: 42340-99-6 (Adefovir free acid); 193681-12-8 (Alamifovir); 145514-04-1 (Amdoxovir); 124915-24-8 (Carbovir); 144606-93-9(Carbovir triphosphate); 129556-87-2 (Adefovir monophosphate)

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    Molecular Weight (MW)501.47
    FormulaC20H32N5O8P
    CAS No.142340-99-6
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 100 mg/mL (199.4 mM)
    Water:<1 mg/mL
    Ethanol: 100 mg/mL (199.4 mM)
    Other info
    Chemical Name: [2-(6-aminopurin-9-yl)ethoxymethyl-(2,2-dimethylpropanoyloxymethoxy)phosphoryl]oxymethyl 2,2-dimethylpropanoate
    InChi Key: WOZSCQDILHKSGG-UHFFFAOYSA-N
    InChi Code: InChI=1S/C20H32N5O8P/c1-19(2,3)17(26)30-11-32-34(28,33-12-31-18(27)20(4,5)6)13-29-8-7-25-10-24-14-15(21)22-9-23-16(14)25/h9-10H,7-8,11-13H2,1-6H3,(H2,21,22,23)
    SMILES Code: CC(C)(C)C(=O)OCOP(=O)(COCCN1C=NC2=C1N=CN=C2N)OCOC(=O)C(C)(C)C 
    SynonymsGS 0840; GS0840; GS-0840; Hepsera; Preveon. Adefobir; GS-0393; GS-393; GS0393; GS393; GS 0393; GS 393; PMEA


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    In Vitro

    In vitro activity: Adefovir Dipivoxil works by blocking reverse transcriptase, an enzyme that is crucial for the hepatitis B virus (HBV) to reproduce in the body. Adefovir Dipivoxil works by blocking reverse transcriptase, an enzyme that is crucial for the hepatitis B virus (HBV) to reproduce in the body. Adefovir Dipivoxil is used for treatment of hepatitis B and herpes simplex virus infection.

    In VivoAdefovir Dipivoxil reduces Liver HBV DNA to<0.1 pg of viral DNA per mg of total DNA (pg/mg) in transgenic mice expressing hepatitis B virus. Adefovir Dipivoxil treatment also reduces serum HBV DNA to 3.5 log10 genomic equivalents (ge)/mL in transgenic mice expressing hepatitis B virus compared to 5.3 log10 ge/mL for the placebo control group. Adefovir Dipivoxil antiviral activity reaches near maximum viral reduction by day 10 in the liver and reaches an endpoint of liver virus inhibition at 1.0 mg/kg/day.
    Animal modelMice
    Formulation & Dosage1.0 mg/kg/day.
    ReferencesAntiviral Res. 2002 Jul;55(1):27-40.


    These protocols are for reference only. InvivoChem does not independently validate these methods.

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