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    ABT-046
     ABT-046

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V4405
    CAS #: 1031336-60-3 Purity ≥98%

    Description: ABT-046 is a novel, potent, selective, and orally bioavailableinhibitor of diacylglycerol acyltransferase 1 (DGAT-1 ) with IC50 of 8 nM. It was identified from a high-throughput screen against human DGAT-1. Oral administration at doses ≥0.03 mg/kg significantly reduced postprandial triglycerides in mice following an oral lipid challenge. Further assessment in both acute and chronic safety pharmacology and toxicology studies demonstrated a clean profile up to high plasma levels, thus culminating in the nomination of 14 as clinical candidate ABT-046.

    References: J Med Chem. 2012 Feb 23;55(4):1751-1757.


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     ABT-046

    Name: ABT-046
    CAS#: 1031336-60-3
    Chemical Formula: C20H22N4O2
    Exact Mass: 350.1743
    Molecular Weight: 350.422
    Elemental Analysis: C, 68.55; H, 6.33; N, 15.99; O, 9.13
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Technical InformationSynonym: ABT-046; ABT 046; ABT046.
    IUPAC/Chemical Name: 2-[4-[4-(7-aminopyrazolo[1,5-a]pyrimidin-6-yl)phenyl]cyclohexyl]acetic acid
    InChi Key: BWUXSHHOKODNAK-UHFFFAOYSA-N
    InChi Code: InChI=1S/C20H22N4O2/c21-20-17(12-22-18-9-10-23-24(18)20)16-7-5-15(6-8-16)14-3-1-13(2-4-14)11-19(25)26/h5-10,12-14H,1-4,11,21H2,(H,25,26)
    SMILES Code: O=C(O)CC1CCC(C2=CC=C(C3=C(N)N4C(N=C3)=CC=N4)C=C2)CC1


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