| Size | Price | Stock | Qty |
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| 1mg |
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| 5mg |
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| 10mg |
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| Other Sizes |
| Targets |
Colutehydroquinone targets fungal pathogens through its antifungal activity. Its mechanism of action involves disruption of microbial cell processes, likely through interference with cell wall synthesis or membrane integrity. The compound also exhibits antioxidant activity by scavenging reactive oxygen species, suggesting it may target oxidative stress pathways. As an isoflavonoid, it may interact with multiple cellular targets, contributing to its broad-spectrum biological activities.
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| ln Vitro |
Colutehydroquinone demonstrates notable in vitro antifungal activity against various fungal pathogens. It exhibits antimicrobial properties by disrupting microbial cell processes. The compound also shows antioxidant activity through its ability to scavenge reactive oxygen species. These activities are concentration-dependent and have been demonstrated in standard antimicrobial susceptibility assays.
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| ln Vivo |
In vivo activity of colutehydroquinone has not been extensively documented in the available literature. Its notable antifungal and antioxidant properties suggest potential for in vivo efficacy in models of fungal infection and oxidative stress-related conditions. However, further in vivo studies are needed to fully characterize its therapeutic potential, pharmacokinetic properties, and safety profile in animal models.
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| Enzyme Assay |
In vitro antifungal assays for colutehydroquinone typically involve culturing fungal pathogens in the presence of varying concentrations of the compound. Antifungal activity is assessed by measuring inhibition of fungal growth using optical density measurements or colony counting, with minimum inhibitory concentration (MIC) values determined from dose-response curves. Antioxidant activity can be assessed using DPPH radical scavenging assays.
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| Cell Assay |
In vitro cellular assays for colutehydroquinone are not extensively documented. The compound's antifungal activity is assessed using standard fungal growth inhibition assays where fungal cells are cultured in the presence of varying concentrations of the compound. Antioxidant activity can be evaluated by measuring reactive oxygen species levels in treated cells using fluorescent probes such as DCFH-DA.
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| Animal Protocol |
In vivo animal experiments for colutehydroquinone are not extensively documented. If used in animal models of fungal infection, typical protocols would involve administering the compound to infected animals and evaluating efficacy by measuring fungal load in tissues or clinical outcomes. Further studies are needed to characterize its in vivo efficacy and safety.
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| ADME/Pharmacokinetics |
Pharmacokinetic data for colutehydroquinone are limited. The compound has a molecular weight of 332.35 and a molecular formula of C18H20O6. It is typically stored at room temperature in continental US; may vary elsewhere. Its absorption, distribution, metabolism, and excretion properties have not been fully characterized. Further pharmacokinetic studies are needed to determine its bioavailability and systemic exposure.
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| Toxicity/Toxicokinetics |
Colutehydroquinone has shown low toxicity in preliminary studies. As a natural product-derived isoflavonoid, it is generally considered to have moderate safety, but comprehensive toxicological studies have not been reported. The compound is intended for research use only. Standard laboratory safety precautions should be followed when handling this compound.
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| References | |
| Additional Infomation |
Reports indicate that Colutea arborescens contains Colutehydroquinone, and relevant data is available for reference.
Colutehydroquinone (CAS#: 181311-16-0) is an isoflavonoid natural product isolated from Colutea arborescens root bark. It exhibits antifungal, antimicrobial, and antioxidant activities. Purity is typically >98%. The compound is of interest in natural product research focused on developing therapeutic agents for inflammation and infection-related conditions. It is for research use only. |
| Molecular Formula |
C18H20O6
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|---|---|
| Molecular Weight |
332.35
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| Exact Mass |
332.125
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| CAS # |
181311-16-0
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| PubChem CID |
101997792
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| Appearance |
White to off-white solid powder
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| Boiling Point |
461.2±45.0 °C(Predicted)
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| LogP |
2.9
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
6
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| Rotatable Bond Count |
4
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| Heavy Atom Count |
24
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| Complexity |
405
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| Defined Atom Stereocenter Count |
1
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| SMILES |
COC1=CC2=C(C[C@@H](CO2)C3=CC(=C(C(=C3O)OC)OC)O)C=C1
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| InChi Key |
RRVWIPPRKMQDAO-NSHDSACASA-N
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| InChi Code |
InChI=1S/C18H20O6/c1-21-12-5-4-10-6-11(9-24-15(10)7-12)13-8-14(19)17(22-2)18(23-3)16(13)20/h4-5,7-8,11,19-20H,6,9H2,1-3H3/t11-/m0/s1
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| Chemical Name |
2,3-dimethoxy-5-[(3R)-7-methoxy-3,4-dihydro-2H-chromen-3-yl]benzene-1,4-diol
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture and light. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : 100 mg/mL (300.89 mM)
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| Solubility (In Vivo) |
Solubility in Formulation 1: 2.5 mg/mL (7.52 mM) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), suspension solution; with sonication.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (7.52 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (7.52 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.0089 mL | 15.0444 mL | 30.0888 mL | |
| 5 mM | 0.6018 mL | 3.0089 mL | 6.0178 mL | |
| 10 mM | 0.3009 mL | 1.5044 mL | 3.0089 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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