| Size | Price | Stock | Qty |
|---|---|---|---|
| 1mg |
|
||
| 5mg |
|
||
| 10mg |
|
||
| Other Sizes |
| Targets |
Cleomiscosin A targets inflammatory pathways and oxidative stress. Its anti-inflammatory activity involves modulation of inflammatory mediators and cytokine production. The compound's antioxidant effects involve scavenging free radicals and reducing oxidative stress. Its hepatoprotective effects suggest additional targets in liver cells.
|
|---|---|
| ln Vitro |
Cleomiscosin A demonstrates in vitro anti-inflammatory, antioxidant, and hepatoprotective activities. It exhibits anti-inflammatory activity by modulating cytokine production in immune cells. The compound's antioxidant activity is demonstrated in DPPH radical scavenging assays. Its hepatoprotective effects are assessed in liver cell models of injury.
|
| ln Vivo |
In vivo activity of cleomiscosin A has been suggested by its hepatoprotective and anti-inflammatory properties. The compound has potential for in vivo efficacy in models of liver disease and inflammation. Further in vivo studies are needed to evaluate its pharmacokinetic properties, efficacy, and safety profile.
|
| Enzyme Assay |
In vitro enzyme/receptor binding assays for cleomiscosin A are not extensively documented. Its anti-inflammatory activity can be assessed by measuring cytokine production in activated immune cells. Antioxidant activity is assessed using DPPH or ABTS radical scavenging assays. Hepatoprotective effects can be evaluated in liver cell cultures treated with hepatotoxic agents.
|
| Cell Assay |
In vitro cellular assays for cleomiscosin A involve treating immune cells or liver cells with varying concentrations of the compound. Anti-inflammatory activity is assessed by measuring cytokine levels using ELISA. Antioxidant activity is evaluated by measuring ROS levels using fluorescent probes. Hepatoprotective effects are assessed by measuring cell viability and liver enzyme levels in hepatotoxic models.
|
| Animal Protocol |
In vivo animal experiments for cleomiscosin A would typically involve administering the compound to animal models of liver disease or inflammation. Efficacy is evaluated by measuring liver enzyme levels, inflammatory markers, oxidative stress biomarkers, and histopathological analysis.
|
| ADME/Pharmacokinetics |
Pharmacokinetic data for cleomiscosin A are limited. The compound has a molecular weight of 386.35 and a molecular formula of C20H18O8. Its absorption, distribution, metabolism, and excretion properties have not been fully characterized. Further pharmacokinetic studies are needed to determine its bioavailability.
|
| Toxicity/Toxicokinetics |
Toxicological data for cleomiscosin A are limited. As a natural product-derived compound, it is generally considered to have low toxicity, but comprehensive toxicological studies have not been reported. The compound is intended for research use only. Standard laboratory safety precautions should be followed when handling this compound.
|
| References | |
| Additional Infomation |
Cleomiscosine A is an organic heterotricyclic compound with the structure 2,3-dihydro-9H-[1,4]dioxanehexeno[2,3-h]chromen-9-one, substituted at position 3 with 4-hydroxy-3-methoxyphenyl, position 2 with hydroxymethyl, and position 5 with methoxy (2R,3R stereoisomer). It possesses anti-inflammatory activity, functioning as both a metabolite and an anti-inflammatory agent. It is a δ-lactone, aromatic ether, organic heterotricyclic compound, phenolic compound, and primary alcohol. Cleomiscosine A has been reported to be found in Erycibe obtusifolia, Hibiscus taiwanensis, and other organisms with relevant data.
Cleomiscosin A (CAS#: 76948-72-6) has the molecular formula C20H18O8 and a molecular weight of 386.35. It is a natural coumarinolignan with anti-inflammatory, antioxidant, and hepatoprotective activities. The compound is used in research on liver diseases and inflammatory conditions. It is for research use only. |
| Molecular Formula |
C20H18O8
|
|---|---|
| Molecular Weight |
386.35
|
| Exact Mass |
386.1
|
| CAS # |
76948-72-6
|
| PubChem CID |
442510
|
| Appearance |
White to off-white solid powder
|
| Density |
1.4±0.1 g/cm3
|
| Boiling Point |
632.7±55.0 °C at 760 mmHg
|
| Melting Point |
245-247ºC
|
| Flash Point |
228.5±25.0 °C
|
| Vapour Pressure |
0.0±2.0 mmHg at 25°C
|
| Index of Refraction |
1.618
|
| LogP |
1.44
|
| Hydrogen Bond Donor Count |
2
|
| Hydrogen Bond Acceptor Count |
8
|
| Rotatable Bond Count |
4
|
| Heavy Atom Count |
28
|
| Complexity |
595
|
| Defined Atom Stereocenter Count |
2
|
| SMILES |
COC1=C(C=CC(=C1)[C@@H]2[C@H](OC3=C4C(=CC(=C3O2)OC)C=CC(=O)O4)CO)O
|
| InChi Key |
OCBGWPJNUZMLCA-NVXWUHKLSA-N
|
| InChi Code |
InChI=1S/C20H18O8/c1-24-13-7-10(3-5-12(13)22)17-15(9-21)26-20-18-11(4-6-16(23)27-18)8-14(25-2)19(20)28-17/h3-8,15,17,21-22H,9H2,1-2H3/t15-,17-/m1/s1
|
| Chemical Name |
(2R,3R)-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-5-methoxy-2,3-dihydropyrano[3,2-h][1,4]benzodioxin-9-one
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO : 125 mg/mL (323.54 mM)
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.08 mg/mL (5.38 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.5883 mL | 12.9416 mL | 25.8833 mL | |
| 5 mM | 0.5177 mL | 2.5883 mL | 5.1767 mL | |
| 10 mM | 0.2588 mL | 1.2942 mL | 2.5883 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
