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| 100mg |
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| 500mg |
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| ln Vitro |
In MDCK/Bcrp1 cells, 5,7-Dimethoxyflavone (5 and 50 μM, 1 hour) inhibits Bcrp1-mediated sorafenib efflux [2]. In B16F10 melanoma cells, 5,7-dimethoxyflavone (0-25 μM, 48 hours) promotes melanogenesis by raising cAMP [4]. 5,7-dimethoxyflavone (0 - 100 μM, 48 hours) can block ischemia, promote oxidative termination, and trigger apoptosis in VK2/E6E7 and End1/E6E7 cells. It can also dilute the cells in cells by accumulation of TG in 3T3-L1 adipocytes [6].Cell.
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| ln Vivo |
In mouse liver, 5,7-dimethoxyflavone (10 mg/kg, facial, once daily for 10 days) can lower the expression levels of CYP3A11 and CYP3A25 proteins [1]. In HFD mice, 5,7-Dimethoxyflavone (25 and 50 mg/kg, face) and 5,7-Dimethoxyflavone (50 mg/kg/d, epidermis, for 6 weeks) decrease body weight while increasing and inhibiting liver function[5].
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| Cell Assay |
Western Blot Analysis[4]
Cell Types: B16F10 melanoma cells Tested Concentrations: 0-25 μM Incubation Duration: 48 hrs (hours) Experimental Results: Induces CREB phosphorylation and inhibits Akt and GSK-3β phosphorylation. |
| Animal Protocol |
Animal/Disease Models: Aged mice [3]
Doses: 25 and 50 mg/kg Route of Administration: Oral Experimental Results: Increased grip strength and running endurance. Increase muscle size, weight, and cross-sectional area. Serum and gastrocnemius muscle IL-6 and TNF-α levels were diminished. |
| References |
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| Additional Infomation |
Chrysin 5,7-dimethyl ether is a dimethoxyflavone that is the 5,7-dimethyl ether derivative of chrysin. It has a role as a plant metabolite. It is functionally related to a chrysin.
5,7-Dimethoxyflavone has been reported in Boesenbergia rotunda, Kaempferia parviflora, and other organisms with data available. |
| Molecular Formula |
C17H14O4
|
|---|---|
| Molecular Weight |
282.2907
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| Exact Mass |
282.089
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| CAS # |
21392-57-4
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| PubChem CID |
88881
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| Appearance |
White to yellow solid powder
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| Density |
1.2±0.1 g/cm3
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| Boiling Point |
476.6±45.0 °C at 760 mmHg
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| Melting Point |
150-152ºC
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| Flash Point |
213.4±28.8 °C
|
| Vapour Pressure |
0.0±1.2 mmHg at 25°C
|
| Index of Refraction |
1.598
|
| LogP |
3.27
|
| Hydrogen Bond Donor Count |
0
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| Hydrogen Bond Acceptor Count |
4
|
| Rotatable Bond Count |
3
|
| Heavy Atom Count |
21
|
| Complexity |
411
|
| Defined Atom Stereocenter Count |
0
|
| InChi Key |
JRFZSUMZAUHNSL-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C17H14O4/c1-19-12-8-15(20-2)17-13(18)10-14(21-16(17)9-12)11-6-4-3-5-7-11/h3-10H,1-2H3
|
| Chemical Name |
5,7-dimethoxy-2-phenylchromen-4-one
|
| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO : ~62.5 mg/mL (~221.40 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (8.86 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (8.86 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. View More
Solubility in Formulation 3: ≥ 2.08 mg/mL (7.37 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.5425 mL | 17.7123 mL | 35.4246 mL | |
| 5 mM | 0.7085 mL | 3.5425 mL | 7.0849 mL | |
| 10 mM | 0.3542 mL | 1.7712 mL | 3.5425 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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