| Size | Price | Stock | Qty |
|---|---|---|---|
| 250mg |
|
||
| 500mg |
|
||
| 1g |
|
||
| Other Sizes |
| Targets |
- The activity of 3-Hydroxy-4-methoxycinnamic acid is mediated by beta-endorphin in streptozotocin-induced diabetic rats [1]
|
|---|---|
| ln Vivo |
- In streptozotocin-induced diabetic rats, administration of 3-Hydroxy-4-methoxycinnamic acid reduces plasma glucose levels, and this glucose-lowering effect is mediated by beta-endorphin [1]
- In mice with lethal influenza virus pneumonia, administration of 3-Hydroxy-4-methoxycinnamic acid significantly improves the survival rate [2] |
| Animal Protocol |
- For streptozotocin-induced diabetic rats: The diabetic model is established via streptozotocin treatment. 3-Hydroxy-4-methoxycinnamic acid is administered, and plasma glucose levels are monitored to evaluate its glucose-lowering effect [1]
- For mice with lethal influenza virus pneumonia: The pneumonia model is established by infecting mice with influenza virus. 3-Hydroxy-4-methoxycinnamic acid is administered, and the survival rate of mice is recorded to assess its therapeutic effect [2] |
| ADME/Pharmacokinetics |
Metabolism / Metabolites
The known metabolites of Isoferulic acid include (2S,3S,4S,5R)-6-[5-[(E)-2-carboxyvinyl]-2-methoxyphenoxy]-3,4,5-trihydroxyoxacyclohexane-2-carboxylic acid. |
| References |
|
| Additional Infomation |
Isoferulic acid is a ferulic acid derivative consisting of trans-cinnamic acid with methoxy and hydroxy substituents at the 4 and 3 positions of the benzene ring, respectively. It has the functions of metabolite, biomarker and antioxidant.
It has been reported that Isoferulic acid is found in danshen, Sichuan poplar and other organisms with relevant data. See also: black cohosh (part); sweet potato leaf (part) -3-hydroxy-4-methoxycinnamic acid Also known as Isoferulic acid[1] -3-hydroxy-4-methoxycinnamic acid Its hypoglycemic effect in diabetic rats is mediated by β-endorphin[1] -3-hydroxy-4-methoxycinnamic acid It has potential therapeutic activity in improving the survival rate of mice with fatal influenza virus pneumonia[2] |
| Molecular Formula |
C10H10O4
|
|---|---|
| Molecular Weight |
194.1840
|
| Exact Mass |
194.057
|
| CAS # |
537-73-5
|
| Related CAS # |
trans-Isoferulic acid;25522-33-2
|
| PubChem CID |
736186
|
| Appearance |
White to off-white solid powder
|
| Density |
1.3±0.1 g/cm3
|
| Boiling Point |
410.2±35.0 °C at 760 mmHg
|
| Melting Point |
230 °C (dec.)(lit.)
|
| Flash Point |
167.6±19.4 °C
|
| Vapour Pressure |
0.0±1.0 mmHg at 25°C
|
| Index of Refraction |
1.627
|
| LogP |
1.56
|
| Hydrogen Bond Donor Count |
2
|
| Hydrogen Bond Acceptor Count |
4
|
| Rotatable Bond Count |
3
|
| Heavy Atom Count |
14
|
| Complexity |
224
|
| Defined Atom Stereocenter Count |
0
|
| SMILES |
COC1=C(C=C(C=C1)/C=C/C(=O)O)O
|
| InChi Key |
QURCVMIEKCOAJU-HWKANZROSA-N
|
| InChi Code |
InChI=1S/C10H10O4/c1-14-9-4-2-7(6-8(9)11)3-5-10(12)13/h2-6,11H,1H3,(H,12,13)/b5-3+
|
| Chemical Name |
(E)-3-(3-hydroxy-4-methoxyphenyl)prop-2-enoic acid
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO : ~100 mg/mL (~514.99 mM)
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.08 mg/mL (10.71 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.08 mg/mL (10.71 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.08 mg/mL (10.71 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 5.1499 mL | 25.7493 mL | 51.4986 mL | |
| 5 mM | 1.0300 mL | 5.1499 mL | 10.2997 mL | |
| 10 mM | 0.5150 mL | 2.5749 mL | 5.1499 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
